Innate B Cells: the Archetype of Protective Immune Cells

Grasseau, Alexis; Boudigou, Marina; Pottier, Laëtitia Le; Chriti, Nedra; Cornec, Divi; Pers, Jacques‐Olivier; Renaudineau, Yves; Hillion, Sophie

doi:10.1007/s12016-019-08748-7

Cited by 32 publications

(23 citation statements)

References 140 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Marginal zone (MZ) B cells are a class of innate-like lymphocytes positioned in the marginal zone of the spleen, inhabiting a junction between the circulation and lymphoid follicle [ 178 , 179 , 180 ]. While some differences exist between human and mouse MZ B development and function, in both organisms the positioning of MZ B cells within the spleen allows them to act as antibody generating first responders against pathogens in the blood [ 178 , 181 ].…”

Section: Adaptive Immune Cellsmentioning

confidence: 99%

Contributions of Major Cell Populations to Sjögren’s Syndrome

Witas

Gupta

Nguyen

2020

JCM

View full text Add to dashboard Cite

Sjögren’s syndrome (SS) is a female dominated autoimmune disease characterized by lymphocytic infiltration into salivary and lacrimal glands and subsequent exocrine glandular dysfunction. SS also may exhibit a broad array of extraglandular manifestations including an elevated incidence of non-Hodgkin’s B cell lymphoma. The etiology of SS remains poorly understood, yet progress has been made in identifying progressive stages of disease using preclinical mouse models. The roles played by immune cell subtypes within these stages of disease are becoming increasingly well understood, though significant gaps in knowledge still remain. There is evidence for distinct involvement from both innate and adaptive immune cells, where cells of the innate immune system establish a proinflammatory environment characterized by a type I interferon (IFN) signature that facilitates propagation of the disease by further activating T and B cell subsets to generate autoantibodies and participate in glandular destruction. This review will discuss the evidence for participation in disease pathogenesis by various classes of immune cells and glandular epithelial cells based upon data from both preclinical mouse models and human patients. Further examination of the contributions of glandular and immune cell subtypes to SS will be necessary to identify additional therapeutic targets that may lead to better management of the disease.

show abstract

Section: Adaptive Immune Cellsmentioning

confidence: 99%

Contributions of Major Cell Populations to Sjögren’s Syndrome

Witas

Gupta

Nguyen

2020

JCM

View full text Add to dashboard Cite

show abstract

“…The blueprints from these NAbs are inscribed in the sequence of the B-cell receptors on a distinct B-cell subset, called B1 cells. 53,54 Supported by our correlation analyses, at this point, we can only speculate that the anti-TDP-43 IgM producing B1-cell population may already be reduced or impaired in the prodromal phase of ALS, resulting in an overload of TDP-43 protein. This situation could result in a greater pressure on the clearance mechanisms.…”

Section: Discussionmentioning

confidence: 75%

TDP-43–specific Autoantibody Decline in Patients With Amyotrophic Lateral Sclerosis

Nielsen

Folke

Owczarek

et al. 2021

Neurol Neuroimmunol Neuroinflamm

View full text Add to dashboard Cite

ObjectiveWe hypothesize alterations in the quality and quantity of anti–43-kDa TAR DNA-binding protein (TDP-43) naturally occurring autoantibodies (NAbs) in patients with amyotrophic lateral sclerosis (ALS); therefore, we assessed relative binding properties of anti–TDP-43 NAbs composite in plasma from patients with ALS in comparison with healthy individuals.MethodsELISA competition assay was used to explore the apparent avidity/affinity of anti–TDP-43 NAbs in plasma from 51 normal controls and 30 patients with ALS. Furthermore, the relative levels of anti–TDP-43 NAbs within the immunoglobulin (Ig) classes of IgG (isotype IgG1-4) and IgMs were measured using classical indirect ELISA. The occurring results were hereafter correlated with the measures of disease duration and disease progression.ResultsHigh-avidity/affinity anti–TDP-43 NAbs levels were significantly reduced in plasma samples from patients with ALS. In addition, a significant decrease in relative levels of anti–TDP-43 IgG3 and IgM NAbs and a significant increase in anti–TDP-43 IgG4 NAbs were observed in ALS plasma vs controls. Furthermore, a decrease in global IgM and an increase in IgG4 levels were observed in ALS. These aberrations of humoral immunity correlated with disease duration, but did not correlate with ALS Functional Rating Scale–Revised scores.ConclusionsOur results may suggest TDP-43–specific immune aberrations in patients with ALS. The skewed immune profiles observed in patients with ALS could indicate a deficiency in the clearance capacity and/or blocking of TDP-43 transmission and propagation. The decrease in levels of high affinity/avidity anti-TDP-43 NAbs and IgMs correlates with disease progression and may be disease predictors.

show abstract

“…The control of the EF response and the reactivation of natural innate or chronically activated B cells appear essential in autoimmunity and acute viral infections such as SARS-CoV2 or influenza (61). The convergent and balanced existence of different EF progenitors could participate in the homeostasis of a such response, providing protective rapid immunity but which could lead to an exacerbated inflammatory response (9). In this regard, innate MZB cell (USM) differentiation seems impaired in patients with systemic lupus erythematosus and Sjögren's syndrome (63).Therefore, elucidation of the cellular and molecular actors controlling the initial B-cell activation toward MZB or FO developmental pathway would be promising for better care of systemic autoimmune diseases and hyper-inflammatory syndromes.…”

Section: Discussionmentioning

confidence: 99%

IL-21 and IFN-alpha have both opposite and redundant role on human innate precursors and memory B-cell differentiation

Boudigou¹,

Michée-Cospolite²,

Hémon³

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Immunological memory is essential for effective immune protection upon antigen rechallenge. Memory B cells encompass multiple subsets, heterogeneous in terms of phenotypes, origins and precursors, anatomical localization, and functional responses. B-cell responses are conditioned by micro-environmental signals, including cytokines. Here, we analyzed in vitro the effects of two cytokines implicated in B-cell differentiation, interferon-alpha (IFN-α) and interleukin (IL)-21, on the early functional response of four different mature B-cell subsets (IgD- CD27- naive, IgD+ CD27+ unswitched, IgD- CD27+ switched and double-negative B cells). The dual response of naive and memory B cells to IL-21 allowed us to uncover a unique IgD+ CD27- CD10- B-cell population (referred to as NARB+) characterized by the expression of marginal zone B-cell markers CD45RB and CD1c. Similar to memory B cells, NARB+ cells were in a pre-activated state, allowing them to rapidly differentiate into plasmablasts upon innate signals while maintaining their susceptibility to IL-21 activation-induced apoptosis as observed for the naive compartment. Both in-depth phenotypic analysis of circulating B cells, and identification of these cells in spleen, tonsil and gut-associated lymphoid tissues, supported that NARB+ are uncommitted precursors of human marginal zone B cells.

show abstract

Innate B Cells: the Archetype of Protective Immune Cells

Cited by 32 publications

References 140 publications

Contributions of Major Cell Populations to Sjögren’s Syndrome

Contributions of Major Cell Populations to Sjögren’s Syndrome

TDP-43–specific Autoantibody Decline in Patients With Amyotrophic Lateral Sclerosis

IL-21 and IFN-alpha have both opposite and redundant role on human innate precursors and memory B-cell differentiation

Contact Info

Product

Resources

About