Innate immune response of bovine mammary gland to pathogenic bacteria responsible for mastitis

Oviedo-Boyso, Javier; Valdéz-Alarcón, Juan José; Cajero-Juárez, Marcos; Ochoa‐Zarzosa, Alejandra; López‐Meza, Joel E.; Bravo-Patiño, Alejandro; Baizabal-Aguirre, Víctor M.

doi:10.1016/j.jinf.2006.06.010

Cited by 302 publications

(255 citation statements)

References 108 publications

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“…The former class of proteins act to recruit additional immune cells to the site of incipient infection while the latter act to neutralise the pathogen directly. These essential features of innate immune pathways have increasingly been elucidated at the molecular level in the past 10 years and have been extensively reviewed (Oviedo-Boyso et al, 2007;Kawai and Akira, 2010). The most well-known of these pathways involves a family of structurally related proteins known as the Toll-like receptors (TLRs), which are found on the plasma membrane or on endosomes, each of which is activated by a distinct molecular pattern, which are often, but not always, pathogenderived.…”

Section: Components Of the Innate Immune Systemmentioning

confidence: 99%

Host-defence-related proteins in cows’ milk

Wheeler

Smolenski

Harris

et al. 2012

Animal

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Milk is a source of bioactive molecules with wide-ranging functions. Among these, the immune properties have been the best characterised. In recent years, it has become apparent that besides the immunoglobulins, milk also contains a range of minor immune-related proteins that collectively form a significant first line of defence against pathogens, acting both within the mammary gland itself as well as in the digestive tract of the suckling neonate. We have used proteomics technologies to characterise the repertoire of host-defence-related milk proteins in detail, revealing more than 100 distinct gene products in milk, of which at least 15 are known host-defence-related proteins. Those having intrinsic antimicrobial activity likely function as effector proteins of the local mucosal immune defence (e.g. defensins, cathelicidins and the calgranulins). Here, we focus on the activities and biological roles of the cathelicidins and mammary serum amyloid A. The function of the immune-related milk proteins that do not have intrinsic antimicrobial activity is also discussed, notably lipopolysaccharide-binding protein, RNase4, RNase5/angiogenin and cartilage-glycoprotein 39 kDa. Evidence is shown that at least some of these facilitate recognition of microbes, resulting in the activation of innate immune signalling pathways in cells associated with the mammary and/or gut mucosal surface. Finally, the contribution of the bacteria in milk to its functionality is discussed. These investigations are elucidating how an effective first line of defence is achieved in the bovine mammary gland and how milk contributes to optimal digestive function in the suckling calf. This study will contribute to a better understanding of the health benefits of milk, as well as to the development of high-value ingredients from milk.

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Section: Components Of the Innate Immune Systemmentioning

confidence: 99%

Host-defence-related proteins in cows’ milk

Wheeler

Smolenski

Harris

et al. 2012

Animal

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“…Em uma glândula mamária saudável em lactação, a CCS total é muitas vezes menor que 20 5 CS/ml de leite. Durante uma infecção intramamária bacteriana, no entanto, a CCS total pode aumentar para mais de 10 6 CS/ml de leite dentro de poucas horas (Oviedo-Boyso et al, 2007). A CCS no leite é influenciada por vários fatores, como a espécie animal, o nível de produção de leite, estágio de lactação, e também os fatores individuais e ambientais, bem como práticas de manejo (Rupp et al, 2000).…”

Section: Defesa Celularunclassified

“…A resposta à resistência à mastite é uma característica complexa e os genes envolvidos na resposta imune têm sido indicados como fortes candidatos para determinar a resistência de animais (Ferens et al, 1998;Alluwaimi et al, 2003;Rambeaud et al, 2003;Oviedo-Boyso et al, 2007;Fonseca et al, 2009). O sistema imunológico é um mecanismo específico que um animal tem para limitar infecções, sendo fundamental para a sobrevivência do animal e, por isso, precisa atuar de forma eficiente.…”

Section: Introductionunclassified

Melhoramento genético visando à resistência a mastite em bovinos leiteiros

et al. 2014

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ADDITIONAL KEYWORDSImmunity. Genetic parameters. RESUMOCom essa revisão, objetivou-se traçar a trajetória dos estudos sobre as características físicas, ambientais e genéticas de resistência à mastite. Uma característica complexa e multifatorial pode ser adquirida por traumas físicos, alterações fisiológicas e metabólicas, microrganismos patogênicos ambientais ou contagiosos e por componentes genéticos envolvidos na resposta imune. As maiores perdas estão relacionadas à diminuição da produção e qualidade do leite, menores ganhos genéticos anuais e baixa intensidade de seleção, sendo citada como a principal doença da bovinocultura leiteira.Diante disso, novos critérios de seleção foram estabelecidos para aumentar a produção de leite e a resistência à mastite, além da melhoria do ambiente. Estudos genômicos têm sido recomendados quando há dificuldade na coleta de dados fenotípicos e a herdabilidade da característica avaliada é baixa.Além do mais, eles são utilizados como ferramenta auxiliar ao melhoramento genético clássico para aumentar a resistência genética a doenças e desenvolver soluções tecnológicas inovadoras. Muitos trabalhos foram realizados para identificar e estudar genes candidatos envolvidos na resposta de resistência à mastite que estão correlacionadas com lócus de características quantitativas (QTL -Quantitative Trait Loci) em programas de seleção assistida por marcadores moleculares. Isto permite a seleção mais rápida e precisa de bovinos pelo seu valor genético genômico, estimado a partir de equações de predição, tornando o melhoramento genético um componente de uma estratégia de longo prazo para o aumento da resistência à mastite e melhoria da qualidade do leite.

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“…Innate immunity is a target of choice for selecCorrespondence to: K. Musayeva, e-mail: kristina.musayeva@lsmuni.lt tion against infectious diseases (Rainard and Riollet 2006). Immune factors in colostrum and milk play an important role in the host defense of the mammary gland itself, protecting it from pathogenic organisms (Sordillo et al 1997, Oviedo-Boyso et al 2007). The mammary host defense system has evolved into an extremely well-developed, complex, and highly effec-tive barrier against pathogens, integrating both the innate and acquired immune response.…”

Section: Introductionmentioning

confidence: 99%

Concentration of lactoferrin and immunoglobulin G in cows’ milk in relation to health status of the udder, lactation and season

Musayeva¹,

Sederevičius²,

Želvytė³

et al. 2016

Polish Journal of Veterinary Sciences

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The aim of this study was to analyze an effect of udder health status, somatic cell count (SCC), stage and number of lactations, and different seasons on the concentration of lactoferrin (LF) and immunoglobulin G (IgG) in quarter milk samples (n=120) from crossbreed (Lithuanian Black-and-White & Holstein) dairy cows. Quarter health status was based on SCC and microbiological analysis. The highest mean value of LF and IgG were observed in quarters with subclinical mastitis 0.1 ± 0.02 mg/ml and 0.41 ± 0.06 mg/ml, respectively. Grouping the data according to SCC revealed increased LF (0.07 ± 0.01 mg/ml as against 0.06 ± 0.01 mg/ml) and IgG values (0.27 ± 0.05 mg/ml as against 0.23 ± 0.02 mg/ml) in DQ (SCC from 201,000 ≥ 401,000 cells/ml) compared to HQ (SCC up to 200,000 cells/ml). The milk LF and IgG levels were effected by stage of lactation (p<0.01 and p<0.05, respectively) and season of the year (p<0.001 and p<0.001, respectively). Nevertheless, SCC and subsequent lactation (p>0.05) had no effect on these immunity components.

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Innate immune response of bovine mammary gland to pathogenic bacteria responsible for mastitis

Cited by 302 publications

References 108 publications

Host-defence-related proteins in cows’ milk

Host-defence-related proteins in cows’ milk

Melhoramento genético visando à resistência a mastite em bovinos leiteiros

Concentration of lactoferrin and immunoglobulin G in cows’ milk in relation to health status of the udder, lactation and season

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