Innate immune response to peritoneal bacterial infection

Català, Cristina; Andrés, María Velasco-de; Casadó-Llombart, Sergi; Leyton-Pereira, Alejandra; Carrillo-Serradell, Laura; Isamat, Marcos; Lozano, Francisco

doi:10.1016/bs.ircmb.2022.04.014

Cited by 9 publications

(9 citation statements)

References 99 publications

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“…Innate immunity is the first line of defense against microbial infection. In particular, as professional phagocytes in host, neutrophils and macrophages predominate during the initial innate immune response to pathogens, and their numbers at the site of infection are an important indicator of the host immune status. , Therefore, we first investigated whether Gy-CATH stimulates the influx of these phagocytes in mice. As shown in Figure A, the number of neutrophils and monocytes/macrophages was markedly increased following the administration of 10 mg of Gy-CATH/kg.…”

Section: Resultsmentioning

confidence: 99%

A Nonbactericidal Anionic Antimicrobial Peptide Provides Prophylactic and Therapeutic Efficacies against Bacterial Infections in Mice by Immunomodulatory–Antithrombotic Duality

He,

Ruan,

Liang

et al. 2024

J. Med. Chem.

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Although bactericidal cationic antimicrobial peptides (AMPs) have been well characterized, less information is available about the antibacterial properties and mechanisms of action of nonbactericidal AMPs, especially nonbactericidal anionic AMPs. Herein, a novel anionic antimicrobial peptide (Gy-CATH) with a net charge of −4 was identified from the skin of the frog Glyphoglossus yunnanensis. Gy-CATH lacks direct antibacterial effects but exhibits significantly preventive and therapeutic capacities in mice that are infected with Staphylococcus aureus, Enterobacteriaceae coli, methicillin-resistant Staphylococcus aureus (MRSA), or carbapenem-resistant E. coli (CREC). In vitro and in vivo investigations proved the regulation of Gy-CATH on neutrophils and macrophages involved in the host immune defense against infection. Moreover, Gy-CATH significantly reduced the extent of pulmonary fibrin deposition and prevented thrombosis in mice, which was attributed to the regulatory role of Gy-CATH in physiological anticoagulants and platelet aggregation. These findings show that Gy-CATH is a potential candidate for the treatment of bacterial infection.

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Section: Resultsmentioning

confidence: 99%

A Nonbactericidal Anionic Antimicrobial Peptide Provides Prophylactic and Therapeutic Efficacies against Bacterial Infections in Mice by Immunomodulatory–Antithrombotic Duality

He,

Ruan,

Liang

et al. 2024

J. Med. Chem.

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“…Relative Abundance (% of All Peritoneal Leukocytes) Intra-abdominal infections are usually secondary to disruption of gastrointestinal tract integrity and result in exposure to polymicrobial insult. The typical response to bacterial infection in the peritoneum (reviewed elsewhere [9]) is broadly similar to the innate and adaptive immune response to bacterial infections in other body compartments. Peritoneal macrophages (and dendritic cells) recognise conserved microbial products through different families of pathogen recognition receptors (PRRs).…”

Section: Cell Typementioning

confidence: 99%

“…The complement system, natural antibodies, acute phase proteins, cytokines/ chemokines and antimicrobial peptides all play a role in peritoneal immunity [9]. Historically it has been appreciated that non-cirrhotic ascites (e.g., in congestive cardiac failure or renal failure) have anti-bacterial activity similar to normal peritoneal fluid, whereas cirrhotic ascitic fluid has a marked reduction of both bactericidal and opsonic activities [82].…”

Section: Peritoneal Soluble Immune Factorsmentioning

confidence: 99%

Peritoneal Immunity in Liver Disease

Delo

Forton

Triantafyllou

et al. 2023

Livers

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The peritoneum represents a confined microenvironment that has an emerging role as a distinct immunological compartment. In health, this niche is mainly populated by a heterogenous group of macrophages and T lymphocytes but also Natural Killer cells and B lymphocytes. Together they are crucial for immunological surveillance, clearance of infection and resolution of inflammation. Development of ascites is a defining feature of decompensated liver cirrhosis, and spontaneous bacterial peritonitis is the most frequent bacterial infection occurring in this patient group. Recent studies of ascitic fluid have revealed quantitative, phenotypic and functional differences in both innate and adaptive immune cells compared to the healthy state. This review summarises current knowledge of these alterations and explores how the peritoneum in chronic liver disease is simultaneously an immunologically compromised site and yet capable of provoking an intense inflammatory response. A better understanding of this might enable identification of new therapeutic targets aimed to rebalance the peritoneal immunity and reduce the reliance on antimicrobials in an era of increasing antimicrobial resistance.

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“…However, the role of the immune system has been underestimated, though it is directly involved into inflammation (Davis et al, 2017;Savchenko et al, 2018;Català et al, 2022;Kostylenko et al, 2022). The relevance of our study can be explained by the fact that in the scientific literature few publications on the clarification of morphological aspects of the reaction of local immunity in response to infection of the peritoneal cavity of experimental animals have been found.…”

Section: Introductionmentioning

confidence: 99%

Morphological Characteristics of the Results of Experimental Modeling of Septic Peritonitis

Hryn,

Maksymenko

2024

Int. J. Morphol.

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Experimental studies devoted to the study of the mechanisms of the pathogenesis of acute peritonitis and the development of new methods of medical and surgical treatment are becoming increasingly relevant. Today, experimental medicine knows many different ways to modeling septic peritonitis and eliminate it, but the role of the local immune system is underestimated, whereas it takes a direct part in inflammation. The objective of our work to study morphological features of results of experimental modeling of septic peritonitis in white rats. The study included 15 sexually mature white male rats weighing 276.75±6.56 grams. A simulation of septic peritonitis was performed by perforating the upper part of the cecum with four punctures with a G16 injection needle. As a result of the experiment, after examination of the peritoneal cavity, all 15 animals were diagnosed with omentum tamponade of perforated damage to the caecum. In 11 cases, the perforated wall of the caecum was covered by the greater omentum (73.34 %), and in the other 4 animals, tamponade was performed by one of the epididymal omentum (26.66 %). The initial stage of tamponade with the greater or epididymal omentums of a perforated caecum begins on the first day of the experiment and consists of tight interstitial consolidation between them, as well as in the invasion of blood vessels from the omentum side to the focus of infection, which ensure the delivery of the appropriate immunocompetent cells. As a result of this process, intensive lymphoid infiltrates are formed in this area, as well as the growth of adipose tissue, which isolates the inflammatory focus from the peritoneal cavity with a thick layer.

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Innate immune response to peritoneal bacterial infection

Cited by 9 publications

References 99 publications

A Nonbactericidal Anionic Antimicrobial Peptide Provides Prophylactic and Therapeutic Efficacies against Bacterial Infections in Mice by Immunomodulatory–Antithrombotic Duality

A Nonbactericidal Anionic Antimicrobial Peptide Provides Prophylactic and Therapeutic Efficacies against Bacterial Infections in Mice by Immunomodulatory–Antithrombotic Duality

Peritoneal Immunity in Liver Disease

Morphological Characteristics of the Results of Experimental Modeling of Septic Peritonitis

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