Innate Immune Responses in Pediatric Patients with Gastritis—A Trademark of Infection or Chronic Inflammation?

Meliţ, Lorena Elena; Mărginean, Cristina Oana; Săsăran, Maria Oana; Mocanu, Simona; Ghiga, Dana Valentina; Crișan, Adriana; Bănescu, Claudia

doi:10.3390/children9020121

Cited by 7 publications

(7 citation statements)

References 45 publications

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“…The GG and CG genotypes of NLRP3 rs10754558 were strongly related to ulcerative colitis [ 22 ]. Moreover, CC genotype holders at the NLRP3 rs10754558 locus may have a more severe systemic inflammatory response [ 23 ]. Addobbati et al found that NLRP3 gene rs10754558 is vital in the development and onset of rheumatoid arthritis [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Posttraumatic Osteomyelitis Risks Associated with NLRP3 Gene Polymorphisms in the Chinese Population

Zhang

et al. 2023

JPM

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The purpose of this case–control study was to examine possible links between NLRP3 gene polymorphisms and the risk of developing posttraumatic osteomyelitis (PTOM) in the Chinese population. A total of 306 patients with PTOM and 368 normal controls were genotyped for NLRP3 (rs35829419, rs10754558, rs7525979, rs4612666), ELP2 (rs1785929, rs1789547, rs1785928, rs12185396, rs681757, rs8299, rs2032206, rs559289), STAT3 (rs4796793, rs744166, rs1026916, rs2293152, rs1053004), CASP1 (rs501192, rs580253, rs556205, rs530537), NFKBIA (rs696), NFKB1 (rs4648068), CARD8 (rs204321), and CD14 (rs2569190) using the genotyping technique SNaPshot. The genotype distributions of NLRP3 gene rs10754558 (p = 0.047) and rs7525979 (p = 0.048) significantly differed between the patients and the healthy controls. Additionally, heterozygous models indicated a significant association between NLRP3 rs10754558 and the likelihood of developing PTOM (OR = 1.600, p = 0.039), as did recessive and homozygous models of NLRP3 rs7525979 (OR = 0.248, p = 0.019 and 0.239, p = 0.016, respectively). Collectively, our findings suggest that, in the Chinese population, the risk of developing PTOM was increased by the association between NLRP3 rs10754558 and rs7525979. Therefore, our findings may provide novel insights and guidance in the prevention and development of PTOM.

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Section: Discussionmentioning

confidence: 99%

Posttraumatic Osteomyelitis Risks Associated with NLRP3 Gene Polymorphisms in the Chinese Population

Zhang

et al. 2023

JPM

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“…Notably, a previous study on Helicobacter pylori infection in children showed a significant association between the CC genotype of NLRP3 rs10754558 and eosinophils. [ 32 ] The effect of NLRP3 polymorphisms on eosinophils counts and IgE levels in asthmatic patients warrants further exploration.…”

Section: Discussionmentioning

confidence: 99%

The effects of NLRP3 and MAVS gene polymorphisms on the risk of asthma: A case–control study

Cai

Yin

2022

Medicine

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Genetic factors are important risk factors for asthma. Nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) is closely associated with asthma. Mitochondrial antiviral signaling protein (MAVS) mediates the recruitment of NLRP3 to the mitochondria and activation of the NLRP3 inflammasome. The purpose of this study was to analyze the effects of NLRP3 and MAVS polymorphisms on the risk of asthma and the interactions between them. Children with asthma (n = 127) and healthy children (n = 100) were recruited between August, 2020 and July, 2021. Multiplex polymerase chain reaction and sequencing was used to analyze genotypes of single nucleotide polymorphisms. The multifactor dimensionality reduction statistical method was used to detect and model epistasis of gene–gene interactions. There were significant differences in the distribution of MVAS rs6515831 and NLRP3 rs10925023 genotypes between the asthma and healthy groups. Compared with rs6515831 TT genotype, the results showed that rs6515831CT genotype increased the risk of asthma (odds ratio: 2.243, 95% CI: 1.221–4.122, P = .009). Compared with rs10925023 GG genotype, the results showed that the risk of asthma in the population with rs10925023 TT genotype was lower (odd ratio: 0.643, 95% CI: 0.423–0.979, P = .039). In the genotype of the NLRP3 rs12048215 locus, the IgE level of asthma patients with genotype AG was lower than that of patients with genotype AA. The dendrogram model showed the strongest interaction between rs7272495 and rs10925023, which was expressed in a synergistic manner. Haplotype analysis revealed that rs10925023T/rs7272495G and rs10925023T/rs3272495A were statistically different in distribution between the two groups. The MAVS rs6515831 and NLRP3 rs10925023 polymorphisms were associated with the risk of asthma in children. There may be interactions between NLRP3 and MAVS polymorphisms in the risk of asthma.

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“…There exists a correlation between living conditions and the type of gastritis. The severity of gastritis and inflammation may be associated with genetic polymorphism in certain immune receptor genes [6]. Endogenous risk factors for gastritis include diseases of various internal organs (heart, kidneys, blood disorders, diabetes, etc.…”

Section: Risk Factors For the Development Of Chronic Gastritismentioning

confidence: 99%

Chronic gastritis in pediatrics

Gabueva,

Kalinchuk,

Radchenko

et al. 2023

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Chronic gastritis is one of the most common diseases of the gastrointestinal tract. High rates of gastritis in children are associated with poor nutrition, physical inactivity, drug abuse, bad habits, a number of concomitant diseases, immune disorders, allergization of the body, and stress. Although a significant proportion in the structure of chronic gastritis is occupied by gastritis associated with Helicobacter pylori infection, many clinical forms are diagnosed that are not associated with the presence of a microbial pathogen in the gastric mucosa. The goal is to highlight the problem of chronic gastritis in children, including risk factors, etiology, clinical manifestations, diagnosis and treatment. Materials and methods. To achieve these goals, a literature search was carried out in the PubMed and Google Scholar databases. The search depth did not exceed 5 years. Uninformative and duplicate articles were excluded. The final list of references included 42 articles. Results. In addition to traditional risk factors for adults, the incidence of chronic gastritis in children is influenced by artificial feeding, pathology of pregnancy and childbirth, respiratory infections, decreased mobility, and concomitant pathology. Helicobacter pylori infection is detected in 56% of children referred to a gastroenterologist for gastrointestinal symptoms. Manifestations of gastritis vary from asymptomatic to epigastric pain with dyspeptic symptoms. Conclusion. 1) Currently, up to 30-40% of children suffer from chronic gastritis. 2) Triple therapy regimens are traditionally used to eradicate Helicobacter pylori, but quadruple therapy is used in populations with high resistance to antimicrobial drugs. 3) In the treatment of eosinophilic gastritis, the drugs benralizumab and vedolizumab demonstrate high effectiveness, leading to depletion of the pool of eosinophils in the blood and tissues of the stomach, as well as clinical improvement. 4) Effective treatment for collagen gastritis has not yet been developed. The treatment regimen includes an elimination diet, proton pump inhibitors, and iron supplements.

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Innate Immune Responses in Pediatric Patients with Gastritis—A Trademark of Infection or Chronic Inflammation?

Cited by 7 publications

References 45 publications

Posttraumatic Osteomyelitis Risks Associated with NLRP3 Gene Polymorphisms in the Chinese Population

Posttraumatic Osteomyelitis Risks Associated with NLRP3 Gene Polymorphisms in the Chinese Population

The effects of NLRP3 and MAVS gene polymorphisms on the risk of asthma: A case–control study

Chronic gastritis in pediatrics

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