Innate Immunity, Epithelial Plasticity, and Remodeling in Asthma

Brasier, Allan R.

doi:10.1007/978-3-031-32259-4_13

Advances in Experimental Medicine and Biology

2023

DOI: 10.1007/978-3-031-32259-4_13

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Innate Immunity, Epithelial Plasticity, and Remodeling in Asthma

Allan R. Brasier

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2024

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Cited by 3 publications

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References 110 publications

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“…Epithelial-mesenchymal plasticity (EMP) is a characteristic feature of chronic lung disease ( 4 ). When the epithelium is repeatedly injured, it triggers EMT and the release of fibroblastic growth factors.…”

mentioning

confidence: 99%

“…When the epithelium is repeatedly injured, it triggers EMT and the release of fibroblastic growth factors. This disrupts the epithelial barrier function, expands the subepithelial myofibroblast population, and promotes extracellular matrix (ECM) remodeling ( 4 ). The study conducted by Brake et al.…”

mentioning

confidence: 99%

“…Recent studies have revealed that the chronic activation of the innate immune response (IIR) mediated by NFκB can lead to EMT and airway remodeling in chronic lung disease ( 4 , 6 ). A review by Pan et al.…”

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confidence: 99%

See 2 more Smart Citations

Editorial: Mucosal adaptations to chronic airway injury: mechanisms and interrelationships of epithelial plasticity on innate immunity and airway remodeling

Brasier,

Zhao,

Chung

2024

Front. Immunol.

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confidence: 99%

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confidence: 99%

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Editorial: Mucosal adaptations to chronic airway injury: mechanisms and interrelationships of epithelial plasticity on innate immunity and airway remodeling

Brasier,

Zhao,

Chung

2024

Front. Immunol.

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Eosinophil-Epithelial Cell Interactions in Asthma

Steffan,

Townsend,

Denlinger

et al. 2024

Int Arch Allergy Immunol

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Background: Eosinophils have numerous roles in type 2 inflammation depending on their activation states in the blood and airway or after encounter with inflammatory mediators. Airway epithelial cells have a sentinel role in the lung and, by instructing eosinophils, likely have a foundational role in asthma pathogenesis. Summary: In this review, we discuss various topics related to eosinophil-epithelial cell interactions in asthma, including the influence of eosinophils and eosinophil products, e.g., granule proteins, on epithelial cell function, expression, secretion, and plasticity; the effects of epithelial released factors, including oxylipins, cytokines, and other mediators on eosinophils, e.g., on their activation, expression, and survival; possible mechanisms of eosinophil-epithelial cell adhesion; and the role of intra-epithelial eosinophils in asthma. Key Messages: We suggest that eosinophils and their products can have both injurious and beneficial effects on airway epithelial cells in asthma and that there are bidirectional interactions and signaling between eosinophils and airway epithelial cells in asthma.

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Bioinformatics Analysis and Experimental Validation to Identify Key Glycosylation-Related Genes in Asthma

Li,

Wu,

Tian

et al. 2024

JIR

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Purpose Asthma is a chronic inflammatory disease influenced by complex genetic and environmental factors. Despite extensive research, the intricate pathophysiology of asthma remains incompletely understood. Furthermore, the effects of glycosylation on asthma remain unclear. Considering that glycosylation-related genes have not been reported in patients with asthma, we aimed in this study to identify key glycosylation-related genes involved in asthma and their potential as therapeutic targets. Material and Methods In the GSE63142 microarray dataset, we performed weighted gene co-expression network, protein–protein interaction network, Gene Ontology, Kyoto Encyclopedia of Genes and Genomes pathway enrichment, and CIBERSORT analyses to identify glycosylation-related genes associated with asthma. Subsequently, these key genes were validated in the GSE67472 microarray dataset and BEAS-2B cells. Correlation analysis of key gene expression and clinical characteristics of asthma patients were performed using Spearman correlation analysis. Results Six key glycosylation-related genes related to asthma were identified: FUT5, FUT3, HCRT, B3GNT6, KDELR3, and SCGB1A1. Expression of FUT5, FUT3, B3GNT6, and KDELR3 was significantly upregulated and that of HCRT and SCGB1A1 significantly downregulated in BEAS-2B cells stimulated with IL-13/IL-4. Moreover, expression of key glycosylation-related genes in the peripheral blood of asthma patients correlated strongly with lung function and eosinophils. Conclusion Our findings have implications for identifying potential therapeutic targets and prognostic markers for asthma.

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Innate Immunity, Epithelial Plasticity, and Remodeling in Asthma

Cited by 3 publications

References 110 publications

Editorial: Mucosal adaptations to chronic airway injury: mechanisms and interrelationships of epithelial plasticity on innate immunity and airway remodeling

Editorial: Mucosal adaptations to chronic airway injury: mechanisms and interrelationships of epithelial plasticity on innate immunity and airway remodeling

Eosinophil-Epithelial Cell Interactions in Asthma

Bioinformatics Analysis and Experimental Validation to Identify Key Glycosylation-Related Genes in Asthma

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