Innate-Immunity Genes in Obesity

Михайлова, С. В.; Ivanoshchuk, D.

doi:10.3390/jpm11111201

Cited by 15 publications

(18 citation statements)

References 243 publications

(335 reference statements)

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“…Several studies revealed an association between obesity and the rs758747 T allele. 53 Furthermore, NLRC3 deficiency promotes cutaneous wound healing due to the inhibition of p53 signaling. 54 As p53 is also involved in vascular remodeling and atherosclerosis, 55 thus we speculate that NLRC3 alteration could have reversed the expression and phosphorylation of p53 that is usually observed in advanced atherosclerotic plaques 56 and therefore reduced restenosis susceptibility.…”

Section: Discussionmentioning

confidence: 99%

Genetic Variants in PHACTR1 & LPL Mediate Restenosis Risk in Coronary Artery Patients

Hageh¹,

Chacar²,

Venkatachalam³

et al. 2023

VHRM

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Background and Objective Coronary artery disease (CAD) is a major cause of death worldwide. Revascularization via stent placement or coronary artery bypass grafting (CABG) are standard treatments for CAD. Despite a high success rate, these approaches are associated with long-term failure due to restenosis. Risk factors associated with restenosis were investigated using a case-control association study design. Methods Five thousand two hundred and forty-two patients were enrolled in this study and were assigned as follows: Stenosis Group: 3570 patients with CAD >50% without a prior stent or CABG (1394 genotyped), and Restenosis Group: 1672 patients with CAD >50% and prior stent deployment or CABG (705 genotyped). Binomial regression models were applied to investigate the association of restenosis with diabetes, hypertension, and dyslipidemia. The genetic association with restenosis was conducted using PLINK 1.9. Results Dyslipidemia is a major risk factor (Odds Ratio (OR) = 2.14, P-value <0.0001) for restenosis particularly among men (OR = 2.32, P < 0.0001), while type 2 diabetes (T2D) was associated with an increased risk of restenosis in women (OR = 1.36, P = 0.01). The rs9349379 ( PHACTR1) and rs264 ( LPL ) were associated with an increased risk of restenosis in our patients. PHACTR1 variant was associated with increased risk of restenosis mainly in women and in diabetic patients, while the LPL variant was associated with increased risk of restenosis in men. Conclusion The rs9349379 in PHACTR1 gene is significantly associated with restenosis, this association is more pronounced in women and in diabetic patients. The rs264 in LPL gene was associated with increased risk of restenosis in male patients.

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Section: Discussionmentioning

confidence: 99%

Genetic Variants in PHACTR1 & LPL Mediate Restenosis Risk in Coronary Artery Patients

Hageh¹,

Chacar²,

Venkatachalam³

et al. 2023

VHRM

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“…Pyroptosis is an inflammatory type of programmed cell death characterized by plasma membrane rupture, water influx, cellular swelling, osmotic lysis and release of proinflammatory cytokines into the extracellular space [ 49 ]. Studies show that, in obesity, the death of adipocytes is described as death similar to pyrosis [ 50 ], where infiltrated macrophages aggregate around each dead adipocyte creating a “crown-shaped” structure and this leads to low-grade chronic inflammation [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Does Childhood Obesity Trigger Neuroinflammation?

et al. 2022

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Childhood obesity is constantly increasing around the world, and it has become a major public health issue. Considerable evidence indicates that overweight and obesity are important risk factors for the development of comorbidities such as cognitive decline, neuroinflammation and neurodegenerative diseases. It is known that during obesity, adipose tissue undergoes immune, metabolic and functional changes which could induce a neuroinflammatory response of the central nervous system (CNS). In this context, to inspect if obesity can start to trigger the neuroinflammation from a pediatric age, we surgically collected and analyzed adipose tissue from the periumbilical area of three obese children (AT-OB) and two normal-weight children (AT-Ctrl). We considered the transcriptomic profile of our samples to detect alterations in different biological processes that might be also involved in the inflammatory and neuroinflammatory response. Our results show alterations of lipid and fatty acids metabolism in AT-OB compared to the AT-Ctrl. We also observed an onset of inflammatory response in AT-OB. Interestingly, among the genes involved in neuroinflammation, GRN and SMO were upregulated, while IFNGR1 and SNCA were downregulated. Our study highlights that obesity may trigger inflammation and neuroinflammation from a pediatric age.

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“…They may also have a reduced response to vaccinations [87] . Adipocytes are actively involved in the regulation of inflammation and immunity [88,89] .…”

Section: Obesitymentioning

confidence: 99%

“…A poor nutritional status resulting in under nutrition can impair immunity to an infection due to micronutrient deficiencies [125,126] . On the other hand, over nutrition induces low-grade chronic inflammation caused by excess adiposity [88,89] . The harmful effects of excess body weight on infectious diseases have been discussed under obesity.…”

Section: Dietmentioning

confidence: 99%

Unhealthy lifestyles and their deleterious relationship with infections: A Narrative Review

Agarwal¹

2021

IJMABHR

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Infection morbidity and mortality generate a significant global health burden. Several pandemics throughout human history have caused considerable suffering and killed millions of people. The ongoing Covid-19 pandemic is one such example. Individual lifestyles, if healthy, have been shown to modulate immune function and help fight infection. The five most important lifestyles are diet, obesity, exercise, alcohol consumption, and smoking. A favorable lifestyle or a prudent change result in reducing the risk and severity of infections. These include several viral, bacterial, parasitic, and fungal infections. The medical scientific literature is loaded with large well-done studies that have focused on the individual role of these lifestyles. A direct connection has been identified and verified in most cases. This manuscript provides a narrative review of this lifestyle-infection relationship. The aim is to raise the awareness of health care providers on the significant impact healthy lifestyles can have on infectious diseases. It is hoped that disseminating this data will translate into improved healthcare.

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Innate-Immunity Genes in Obesity

Cited by 15 publications

References 243 publications

Genetic Variants in PHACTR1 & LPL Mediate Restenosis Risk in Coronary Artery Patients

Genetic Variants in PHACTR1 & LPL Mediate Restenosis Risk in Coronary Artery Patients

Does Childhood Obesity Trigger Neuroinflammation?

Unhealthy lifestyles and their deleterious relationship with infections: A Narrative Review

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