Innate Immunity of Airway Epithelium and COPD

Ganesan, Shyamala; Sajjan, Uma S.

doi:10.5772/30828

Cited by 2 publications

(2 citation statements)

References 240 publications

(214 reference statements)

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“…Their internal core contains the drug dissolved or dispersed, and their particle sizes range from 0.01 to 100 µm. (Bekerman et al, 2004;Elgart et al, 2012;Khopade & Jain, 1997) Lipospheres are one of the lipid-based drug delivery systems complying well with the needs of a drug delivery system, as they have high dispersibility in aqueous media, easy in their preparation and scaling up, and their high ability to entrap hydrophobic drugs; enhancing the solubility and permeability characteristics of especially class II and IV drug candidate (Ganesan & Allimalarkodi, 2015;Kumar et al, 2021).…”

Section: Lipospheresmentioning

confidence: 99%

Lipospheres and Pro-Nanolipospheres: Advancements in Drug Delivery Systems

Motawee

Khafagy²,

Gardouh³

et al. 2023

Records of Pharmaceutical and Biomedical Sciences

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The usefulness of nanotechnology nowadays in improving the performance of different active pharmaceutical ingredients (API) has generated a great deal of excitement worldwide. These nano-systems offer the advantage of higher bioavailability, lower toxicity, and the ability to deliver drugs with low half-life or low permeability. Lipid nano-based carriers have been extensively used for their ability to protect the API from degradation and their safety as these used lipids are generally regarded as safe. Lipospheres and Pro-nanolipospheres are among the promising systems for the delivery of water-insoluble drugs. They are composed of aqueous dispersible particles with a rigid hydrophobic lipid centre, coated by an outer protective phospholipid exterior. These lipospheres and Pro-nanolipospheres have the advantage of being easy to scale up, high dispersibility in aqueous media, and improved physical stability, making them the perfect candidate for the delivery of different APIs using different routes including oral, parenteral, intranasal and topical routes.

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Section: Lipospheresmentioning

confidence: 99%

Lipospheres and Pro-Nanolipospheres: Advancements in Drug Delivery Systems

Motawee

Khafagy²,

Gardouh³

et al. 2023

Records of Pharmaceutical and Biomedical Sciences

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“…On the other hand, in path B, indole first reacts directly with the activated aldehyde substrate to form an azafulvene intermediate. 6e Then the excess N , N -dimethylaniline act as a second nucleophile, attacking the azafulvene intermediate to give major product 4a (Sub-Path b). However, the indole nucleophile is a very active nucleophile, and reacts rapidly with the azafulvene intermediate to give a small amount of the minor product 5a (Sub-Path b′).…”

Section: Table 1 Optimization Of the Reaction ...mentioning

confidence: 99%

Brønsted Acidic Ionic Liquid Catalyzed Three-Component Friedel–Crafts Reaction for the Synthesis of Unsymmetrical Triarylmethanes

Rinkam

Senapak

Watchasit

et al. 2022

Synlett

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convenient and practical methodology for the synthesis of unsymmetrical triarylmethanes was demonstrated through a one-pot three-component double Friedel-Craft reaction between various aliphatic aromatic and heteroaromatic aldehydes, N,N-dialkylanilines and indoles using Bronsted acidic ionic liquid as catalyst. This method was successfully performed under metal- and solvent-free conditions at 80oC, affording the corresponding unsymmetrical triarylmethane products in moderate to high yields with a broad range of substrates. In addition, the mechanistic proposal of this methodology was studied by using quantitative NMR analysis (qNMR).

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Innate Immunity of Airway Epithelium and COPD

Cited by 2 publications

References 240 publications

Lipospheres and Pro-Nanolipospheres: Advancements in Drug Delivery Systems

Lipospheres and Pro-Nanolipospheres: Advancements in Drug Delivery Systems

Brønsted Acidic Ionic Liquid Catalyzed Three-Component Friedel–Crafts Reaction for the Synthesis of Unsymmetrical Triarylmethanes

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