Innate inflammatory response to the malarial pigment hemozoin

Shio, Marina Tiemi; Kassa, Fikregabrail Aberra; Bellemare, Marie-Josée; Olivier, Martin

doi:10.1016/j.micinf.2010.07.001

Cited by 77 publications

(88 citation statements)

References 66 publications

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“…H e m o z o i n , o r m a l a r i a p i g m e n t , i s i n s o l u b l e ferriprotoporphyrin I X crystal occurring during detoxification of heme by plasmodium parasite [11] . When PRBCs rupture, hemozoin is released into the blood and is phagocyted by host mononuclear cells such as monocytes and macrophages [11] .…”

Section: Effect Of Hemozoin On Blood Mononuclear Cellsmentioning

confidence: 99%

“…When PRBCs rupture, hemozoin is released into the blood and is phagocyted by host mononuclear cells such as monocytes and macrophages [11] . After hemozoin-phagocytosis, serious dysfunctions of monocytes have been reported, including repeated phagocytosis [12] , bacterial killing abilities [13] , oxidative bursts [14] , MHC class II expression and antigen presentation [13] , maturation to dendritic cells [15] , and coordination of erythropoiesis [16] .…”

Section: Effect Of Hemozoin On Blood Mononuclear Cellsmentioning

confidence: 99%

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Effect of malaria components on blood mononuclear cells involved in immune response

Punsawad

2013

Asian Pacific Journal of Tropical Biomedicine

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Section: Effect Of Hemozoin On Blood Mononuclear Cellsmentioning

confidence: 99%

Section: Effect Of Hemozoin On Blood Mononuclear Cellsmentioning

confidence: 99%

Effect of malaria components on blood mononuclear cells involved in immune response

Punsawad

2013

Asian Pacific Journal of Tropical Biomedicine

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“…The phagocytozed PfHz triggers the innate immune response through the toll-like receptors (TLR's) [36] with downstream cytokine elicitation promoting RANTES suppression by a pathway involving IL-10 [37].…”

Section: Severe Malarial Anemia and The Inflammasomementioning

confidence: 99%

Severe Malarial Anemia (SMA) Pathophysiology and the Use of Phytotherapeutics as Treatment Options

Mavondo¹,

Mzingwane²

2018

Current Topics in Anemia

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Hemolytic anemia results when red blood cells (RBCs) are destroyed prematurely by a number of agents. Obligate intracellular parasites like the Plasmodium species proliferate by infecting RBCs, growing through different stages of their life cycles, expanding their population to unsustainable numbers and eventually rupturing the cell membranes in order to transmit and infect new RBCs. In this manner, more RBCs are infected by the parasites and destroyed together with some nonparasitized cells. Membranes of RBCs are altered and deformed by parasite antigens expressed on the surfaces of both parasitized and nonparasitized cells, which lead to their premature phagocytosis and destruction by the reticuloendothelial system. Parasites and the hemoglobin waste products produced by them are released when the RBCs burst. Activated leukocytes take up the hemoglobin waste (hemozoin which is a polymerized heme), which stimulates the innate immune system leading to the synthesis and secretion of pro-and anti-inflammatory cytokines, chemokines, growth factors and mediators. Together with the destruction of RBCs in malaria, imbalance between pro-and anti-inflammatory events results in the modification of erythroid cell proliferation leading to severe malarial anemia (SMA) and other pathophysiologies of malaria. While current malarial management is targeted at the destruction of the parasite, it is the malaria-related pathophysiology (disease aspect of malaria) like severe malarial anemia that results in the high malaria morbidity and mortality. Antidisease approaches promise to be more effective at malarial management. Triterpenes with antioxidant, pro-oxidant, anti-inflammatory and antiparasitic effect show effects at retarding and abrogating severe malarial anemia. Asiatic acid, amongst other triterpenes like oleanolic acid, masilinic acid administered through oral or transdermal route improves severe malaria anaemia providing promise in the management of malaria pathophysiology.

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“…Activation of phagocytes is mediated by binding of the hemozoin/parasite DNA complex to TLR-9 and the consequent downstream activation of inflammasome signaling [41]. The hemozoin released into circulation during infected RBC lysis is taken up by circulating monocytes and tissue macrophages and activates inflammasome intracellular protein complexes, such as NOD-, LRR-, and pyrin domain-containing (NLRP)3 and NLRP12, resulting in caspase 1 activation and the subsequent release of interleukin (IL)-1β, which is involved in fever during malaria bursts [40,42]. In addition to inducing pro-inflammatory cytokines, some studies demonstrate that hemozoin can also induce the expression of anti-inflammatory cytokines in monocytes, such as IL-10, which tightly regulates IL-12 and CCL5 production [43].…”

Section: Molecular and Cellular Features Of The Malaria-induced Inflamentioning

confidence: 99%

Multiple Organ Dysfunction During Severe Malaria: The Role of the Inflammatory Response

Souza¹,

Pádua²,

Henriques³

2016

Current Topics in Malaria

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Severe malaria is a systemic illness characterized by the dysfunction of one or more peripheral organs, such as the lungs [acute respiratory distress syndrome (ARDS)] and kidneys [acute kidney injury (AKI)]. Several clinical and experimental studies suggest that features of the inflammatory response are related to the multi-organ dysfunction observed in severe malaria. Our group has been dedicated to studying the roles of proand anti-inflammatory mediators in the multi-organ dysfunction observed in experimental severe malaria, especially in the lungs, kidneys, and brain. Herein, we explore severe malaria as a pathology derived from intense inflammatory responses in different organs and further distinguish and compare these organ-specific inflammatory responses. The pathophysiological mechanism of severe malaria is not fully elucidated; however, it is important to study it as a complex inflammatory response assembled by different actors, each one orchestrating a different mechanism.

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Innate inflammatory response to the malarial pigment hemozoin

Cited by 77 publications

References 66 publications

Effect of malaria components on blood mononuclear cells involved in immune response

Effect of malaria components on blood mononuclear cells involved in immune response

Severe Malarial Anemia (SMA) Pathophysiology and the Use of Phytotherapeutics as Treatment Options

Multiple Organ Dysfunction During Severe Malaria: The Role of the Inflammatory Response

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