Innate lymphoid cells — a proposal for uniform nomenclature

Spits, Hergen; Artis, David; Colonna, Marco; Diefenbach, Andreas; Santo, James P. Di; Eberl, Gérard; Koyasu, Shigeo; Locksley, Richard M.; McKenzie, Andrew N. J.; Mebius, Reina E.; Powrie, Fiona; Vivier, Éric

doi:10.1038/nri3365

Cited by 2,082 publications

(2,230 citation statements)

References 49 publications

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“…Group 3 ILC are characterized by IL‐22 and IL‐17 secretion in response to IL‐23 and IL‐1β stimulation 5, 23, 24. ILC3 express the transcription factor RORγt, and the development of mouse ILC3 depends on RORγt, Notch, and Tcf1, as recently summarized elsewhere 6.…”

Section: Ilc Subsetsmentioning

confidence: 96%

“…In addition to NK cells, three major subsets of noncytotoxic ILC have been described during the last decade. The classification of these noncytotoxic ILC into group 1, 2, and 3 ILC is based on their expression of specific transcription factors and cytokine secretion profiles largely reflecting the Th1/Th2/Th17 subsets (Figure 1) 5. Additionally, ILC subsets are defined by the expression pattern of certain cell surface proteins, which are partly different in humans and in mice (Table 1).…”

Section: Development and Classification Of Ilc Subsetsmentioning

confidence: 99%

“…Murine α4β7 + progenitors give rise to CCR6 + T‐bet − ILC3, such as LTi cells, which heterogeneously express CD4. The α4β7 − ILC3 progenitors depend on AhR for their development into CCR6 − T‐bet + ILC3, which may or may not express the NCR NKp46 5.…”

Section: Ilc Subsetsmentioning

confidence: 99%

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Innate Lymphoid Cells in Graft-Versus-Host Disease

Kónya

Mjösberg

2015

American Journal of Transplantation

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Innate lymphoid cells (ILC) are lymphocytes lacking rearranged antigen receptors such as those expressed by T and B cells. ILC are important effector and regulatory cells of the innate immune system, controlling lymphoid organogenesis, tissue inflammation, and homeostasis. The family of ILC consists of cytotoxic NK cells and the more recently described noncytotoxic group 1, 2, and 3 ILC. The classification of noncytotoxic ILC—in many aspects—mirrors that of T helper cells, which is based on the expression of master transcription factors and signature cytokines specific for each subset. The IL‐22 producing RORγt+ ILC3 subset was recently found to be critical in the prevention of intestinal graft‐versus‐host disease (GVHD) following allogeneic hematopoietic cell transplantation (HCT) via strengthening the intestinal mucosal barrier. In this review, we summarize the current view of the immunological functions of human noncytotoxic ILC subsets and discuss the potentially beneficial features of IL‐22 producing ILC3 in improving allo‐HCT efficacy by attenuating susceptibility to GVHD. In addition, we explore the possibility of other ILC subsets playing a role in GVHD.

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Section: Ilc Subsetsmentioning

confidence: 96%

Section: Development and Classification Of Ilc Subsetsmentioning

confidence: 99%

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Innate Lymphoid Cells in Graft-Versus-Host Disease

Kónya

Mjösberg

2015

American Journal of Transplantation

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“…Three groups of ILCs have been defined with distinct patterns of cytokine production that mirrors that of T helper cell subsets, called group 1 ILCs (ILC1), group 2 ILC (ILC2) and group 3 ILC (ILC3) 17. ILC2s produce IL‐5 and IL‐13 in response to epithelial cell‐derived IL33 and/or IL‐25 18, 19, 20.…”

Section: The Ilc Familymentioning

confidence: 99%

Innate‐like CD8+ T‐cells and NK cells: converging functions and phenotypes

2018

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SummaryNew data in the worlds of both innate‐like CD8+ T‐cells and natural killer (NK) cells have, in parallel, clarified some of the phenotypes of these cells and also their associated functions. While these cells are typically viewed entirely separately, the emerging innate functions of T‐cells and, similarly, the adaptive functions of NK cells suggest that many behaviours can be considered in parallel. In this review we compare the innate functions of CD8+ T‐cells (especially mucosal‐associated invariant T‐cells) and those of NK cells, and how these relate to expression of phenotypic markers, especially CD161 and CD56.

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“…NK cells also play an important protective role during parasitic infections such as T. gondii 10. Together with ILC1, NK cells are considered to be part of the group 1 innate lymphoid cell (ILC) family 11. In the murine model, T. gondii has traditionally been considered to stimulate NK cell responses, and depletion of NK cells results in a higher parasite burden at early stages of the infection 12, 13.…”

Section: Introductionmentioning

confidence: 99%

Parasitized Natural Killer cells do not facilitate the spread of Toxoplasma gondii to the brain

Petit-Jentreau

Glover

Coombes

2018

Parasite Immunology

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Summary Toxoplasma gondii is a protozoan parasite capable of invading immune cells and co‐opting their migratory pathways to disseminate through the host. Natural Killer (NK) cells can be directly invaded by the parasite and this invasion alters NK cell migration, producing a hypermotile phenotype. However, the consequences of this hypermotile phenotype for the dissemination of T. gondii to the brain remain unknown. To address this, C57BL6/J mice were infected with freshly egressed tachyzoites (type II Prugniaud strain) or with parasitized NK cells. Under both conditions, parasite loads in the brain were comparable, indicating that parasitized NK cells were not able to facilitate spread of T. gondii to the brain. Consistent with this, we found no evidence for the recruitment of endogenous NK cells to the brain at early time points post‐infection, nor any changes in the expression of α4β1 integrin, involved in recruitment of NK cells to the brain. We therefore found no evidence for a role for hypermotile NK cells in delivery of parasites to the brain during acute infection with T. gondii.

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Innate lymphoid cells — a proposal for uniform nomenclature

Cited by 2,082 publications

References 49 publications

Innate Lymphoid Cells in Graft-Versus-Host Disease

Innate Lymphoid Cells in Graft-Versus-Host Disease

Innate‐like CD8+ T‐cells and NK cells: converging functions and phenotypes

Parasitized Natural Killer cells do not facilitate the spread of Toxoplasma gondii to the brain

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