Innate Lymphoid Cells in the Central Nervous System

Wang, Shuaiwei; Pavert, Serge A. van de

doi:10.3389/fimmu.2022.837250

Cited by 14 publications

(6 citation statements)

References 142 publications

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“…Second, activated phospholipase in leukocytes promotes secretion of active substances, e.g., prostaglandins, eicosanoids, platelet activating factors, and leukotrienes, which induce vasoconstriction and prolong platelet aggregation [ 29 ]. At last, some immune modulators and proinflammatory cytokines are secreted by infiltrated leukocytes in the penumbra zone around the infarct center, which may damage more neurons [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical Value of the Prognostic Nutrition Index in the Assessment of Prognosis in Critically Ill Patients with Stroke: A Retrospective Analysis

Liu

Yang

Kadasah

et al. 2022

Computational and Mathematical Methods in Medicine

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Purpose. The purpose of study was to evaluate the association between prognostic nutritional index (PNI) and all-cause mortality of critically ill patients with stroke. Methods. Clinical data derived from Multiparameter Intelligent Monitoring in Intensive Care were analyzed. The primary endpoint was 30-day all-cause mortality; secondary endpoints were 90-day mortality and one-year cause mortality. The potential prognostic roles of PNI were analyzed by Cox proportional hazard models. The independent prognostic roles of PNI in the cases were analyzed by smooth curve fitting. Results. Concerning 30-day mortality, the HR (95% CI) for a high PNI (≥39.7) was 0.700 (0.544, 0.900; P = 0.00539 ), compared to a low PNI (<39.7). After adjusting for multiple confounders, the HR (95% CI) for a high PNI (≥39.7) was 0.732 (0.547, 0.978; P = 0.03514 ), compared to a low PNI (<39.7). Regarding 90-day and one-year mortality, a similar trend was observed. In addition, a nonlinear association between PNI and 30-day mortality was found. Using recursive algorithm and two-piecewise linear regression model, inflection point (IP) was calculated, which was 49.4. On the right side of the IP, there was a positive relationship between PNI and 30-day mortality, and the effect size, 95% CI, and P value were 1.04 (1.01, 1.07), P = 0.0429 , respectively. On the left of the IP, the effect size, 95% CI, and P value were 0.97 (0.96, 0.99) and 0.0011, respectively. Conclusions. The PNI was an independent predicting factor of 30-day, 90-day, and 1-year mortality of the critically ill patients with stroke. In addition, there was a U-shaped relationship between PNI and all-cause mortality of stroke patients. PNI was a risk factor for the outcome of stroke when PNI was >49.4, while PNI was a protective factor for outcome of stroke when PNI was <49.4.

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Section: Discussionmentioning

confidence: 99%

Clinical Value of the Prognostic Nutrition Index in the Assessment of Prognosis in Critically Ill Patients with Stroke: A Retrospective Analysis

Liu

Yang

Kadasah

et al. 2022

Computational and Mathematical Methods in Medicine

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“…In addition to being the most important component of innate immunity, NK cells are key players in adaptive immunity (Caligiuri, 2008). Over the past decade, accumulating evidence has revealed that CNSinfiltrating NK cells modulate neuroinflammation, establishing an important role for NK cells in neurodegenerative diseases (Poli et al, 2013;Menees and Lee, 2022;Wang and van de Pavert, 2022). In patients with ALS, NK cells are elevated in the peripheral blood (Gustafson et al, 2017;Murdock et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Natural killer cells-related immune traits and amyotrophic lateral sclerosis: A Mendelian randomization study

Gong

Liu²,

Ding³

et al. 2022

Front. Neurosci.

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BackgroundObservational studies have suggested that peripheral immune disorders are associated with amyotrophic lateral sclerosis (ALS). Previous studies predominantly focused on changes in adaptive immunity. However, emerging evidence showed natural killer (NK) cells, an essential component of innate immunity, were involved in the degeneration of motor neurons. However, the causal relationship between dysregulated NK cells-related immune traits and ALS remains unclear.ObjectiveThis study aimed to explore the causal relationship between NK cells-related immune traits and the risk of ALS.Materials and methodsSingle nucleotide polymorphisms (SNPs) significantly associated with NK cells-related immune traits were selected as instrumental variables to estimate their causal effects on ALS. SNPs from a genome-wide association study (GWAS) on NK cells-related immune traits were used as exposure instruments, including an absolute NK-cells count, absolute HLA-DR+ NK-cells count, NK cells/lymphocytes, NK cells/CD3– lymphocytes, HLA DR+ NK cells/NK cells, HLA DR+ NK cells/CD3– lymphocytes, and the median fluorescence intensities of CD16–CD56+ on NK cells and HLA-DR+ NK cells. Summary-level GWAS statistics of ALS were used as the outcome data. Exposure and outcome data were analyzed using the two-sample Mendelian randomization (MR) method.ResultsEach one standard deviation increase in the expression levels of CD16–CD56+ on NK cells and HLA-DR+ NK cells were associated with a lower risk of ALS in both the MR-Egger and inverse variance weighted methods (P < 0.05). The results proved robust under all sensitivity analyses. Neither instrumental outliers nor heterogeneity were detected.ConclusionOur results suggest that higher expression levels of CD16–CD56+ on NK cells and HLA-DR+ NK cells are associated with a lower risk of ALS.

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“…Monocytes, eosinophils, and neutrophils are part of the innate immune system. 12 , 13 The adaptive immune system is essential in recognizing the antigen of tumors and providing helper and killer functions for tumors but often fails to establish immune memory. 14 , 15 In addition, activated dendritic cells (DCs) can present antigens to CD4 + T cells and recruit monocytes or macrophages to the tumor site.…”

Section: Discussionmentioning

confidence: 99%

A novel prognostic risk-scoring system based on m5C methylation regulator-mediated patterns for glioma patients

Wen,

Chen,

et al. 2024

Molecular Therapy: Oncology

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Innate Lymphoid Cells in the Central Nervous System

Cited by 14 publications

References 142 publications

Clinical Value of the Prognostic Nutrition Index in the Assessment of Prognosis in Critically Ill Patients with Stroke: A Retrospective Analysis

Clinical Value of the Prognostic Nutrition Index in the Assessment of Prognosis in Critically Ill Patients with Stroke: A Retrospective Analysis

Natural killer cells-related immune traits and amyotrophic lateral sclerosis: A Mendelian randomization study

A novel prognostic risk-scoring system based on m5C methylation regulator-mediated patterns for glioma patients

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