Innate lymphoid cells—Underexplored guardians of immunity

Tsymala, Irina; Kuchler, Karl

doi:10.1371/journal.ppat.1011678

Cited by 3 publications

(4 citation statements)

References 111 publications

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“…ILCs are widely distributed throughout various tissues and organs, including the cornea and conjunctiva [25,107]. ILCs comprise five different subsets: cytotoxic natural killer cells (NK cells), lymphoid tissue inducer cells, and three helper-like subsets, ILC1s, ILC2s, and ILC3s [108,109]. Notably, we identified NKs, ILC1s, and ILC2s in the mouse lacrimal gland.…”

Section: Ilcs In Mouse Lacrimal Glandsmentioning

confidence: 80%

Exploring Immune Cell Diversity in the Lacrimal Glands of Healthy Mice: A Single-Cell RNA-Sequencing Atlas

Fan,

Yan,

et al. 2024

IJMS

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The lacrimal gland is responsible for maintaining the health of the ocular surface through the production of tears. However, our understanding of the immune system within the lacrimal gland is currently limited. Therefore, in this study, we utilized single-cell RNA sequencing and bioinformatic analysis to identify and analyze immune cells and molecules present in the lacrimal glands of normal mice. A total of 34,891 cells were obtained from the lacrimal glands of mice and classified into 18 distinct cell clusters using Seurat clustering. Within these cell populations, 26 different immune cell subpopulations were identified, including T cells, innate lymphocytes, macrophages, mast cells, dendritic cells, and B cells. Network analysis revealed complex cell-cell interactions between these immune cells, with particularly significant interactions observed among T cells, macrophages, plasma cells, and dendritic cells. Interestingly, T cells were found to be the main source of ligands for the Thy1 signaling pathway, while M2 macrophages were identified as the primary target of this pathway. Moreover, some of these immune cells were validated using immunohistological techniques. Collectively, these findings highlight the abundance and interactions of immune cells and provide valuable insights into the complexity of the lacrimal gland immune system and its relevance to associated diseases.

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Section: Ilcs In Mouse Lacrimal Glandsmentioning

confidence: 80%

Exploring Immune Cell Diversity in the Lacrimal Glands of Healthy Mice: A Single-Cell RNA-Sequencing Atlas

Fan,

Yan,

et al. 2024

IJMS

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“…This risk is further heightened in individuals with comorbidities such as obesity and diabetes [66,67]. ILCs are commonly recognized as the initial defense mechanism against numerous infections, including viral ones [1,68,69]. To date, the role of ILC cells in respiratory-related infections has yet to be clearly defined.…”

Section: Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-cov-2)mentioning

confidence: 99%

“…Natural innate lymphoid cells (ILCs) are a newly described family of immune cells that form part of natural immunity [1,2]. They lack antigen-specific receptors, which allows them to act at the earliest stages of infection.…”

Section: Introductionmentioning

confidence: 99%

“…Understanding their functions and dysregulation in various diseases may provide valuable insights for therapeutic interventions [4,5]. ILCs are distinguished by three main characteristics: (1) the absence of expression of lineage (Lin) markers, (2) the autonomy from recombination activating gene (Rag), and (3) the essential need for the common cytokine receptor γ-chain (γc) [6]. ILCs regulate immune responses, play a role in metabolic homeostasis, prevent tissue damage and tissue maintenance, and mediate responses between glial cells and other immune cells [7].…”

Section: Introductionmentioning

confidence: 99%

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Innate Lymphoid Cells and Their Role in the Immune Response to Infections

Fol,

Karpik,

Zablotni

et al. 2024

Cells

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Over the past decade, a group of lymphocyte-like cells called innate lymphoid cells (ILCs) has gained considerable attention due to their crucial role in regulating immunity and tissue homeostasis. ILCs, lacking antigen-specific receptors, are a group of functionally differentiated effector cells that act as tissue-resident sentinels against infections. Numerous studies have elucidated the characteristics of ILC subgroups, but the mechanisms controlling protective or pathological responses to pathogens still need to be better understood. This review summarizes the functions of ILCs in the immunology of infections caused by different intracellular and extracellular pathogens and discusses their possible therapeutic potential.

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