Inner and outer segment junction (IS/OS line) integrity in ocular Behçet's disease

Abstract

Purpose: In this study, we examined the spectral domain optical coherence tomography (OCT) findings of ocular Behçet's disease (OB) in patients with inactive uveitis. Specifically, we analyzed the inner and outer segment junction (IS/OS line) integrity and the effect of disturbed IS/OS line integrity on visual acuity. Methods: Patient files and OCT images of OB patients who had been followed-up between January and June of the year 2013 at the Dicle University Eye Clinic were evaluated retrospectively. Sixty-six eyes of 39 patients were included the study. Results: OCT examination of the patients with inactive OB revealed that approximately 25% of the patients had disturbed IS/OS and external limiting membrane (EML) line integrity, lower visual acuity (VA), and lower macular thickness than others. Linear regression analysis revealed that macular thickness was not an independent variable for VA. In contrast, the IS/OS line integrity was an independent variable for VA in inactive OB patients. Conclusion: In this study, we showed that the IS/OS line integrity was an independent variable for VA in inactive OB patients. Further prospective studies are needed to evaluate the integrity of the IS/OS line in OB patients.

Measurement of Contrast Sensitivity in Patients with Behçet's Disease without Ocular Involvement

“…BD vasculitis can affect large and small arterial or venous vessels [8]. BD can lead to very different clinical outcomes, and diagnosis may be difficult.…”

“…Coskun et al [19] reported a decrease in choroidal thickness on enhanced SD-OCT in BD patients. BD can affect the nutrient supply to the photoreceptors and cause photoreceptor damage via its effects on the choroidal vessels [819]. In our study, SD-OCT images were obtained for all participants.…”

“…Previous studies have reported that ocular involvement occurs in 23% to 96% of BD patients [678]. Although ocular involvement may be the initial symptom, it usually occurs in the second or third year of the disease [78] and is generally in the form of panuveitis and retinal vasculitis [8].…”

Behçet uveitis: Current practice and future perspectives

“…Other studies have demonstrated that decreased foveal thickness and disruption of the photoreceptor inner and outer segment junction detected by OCT are associated with poor visual function, indicating irreversible damage to the macula ( 60 ).…”

Macular Inner Retinal Layer Thickening and Outer Retinal Layer Damage Correlate With Visual Acuity During Remission in Behcet's Disease

“…17,19 Limited information is available regarding the characterization of changes in intraretinal layers around the macula in BD during remission and the association of those changes with VA. Only two cross-sectional studies using OCT described the disruption of photoreceptor ellipsoid zone (EZ) in BD during remission phase. 20,21 These studies reported that the disruption of photoreceptors is strongly related to the loss of VA. However, until now, no studies have quantified the changes of intraretinal thicknesses around the macula in BD that may also dramatically impact the VA.…”