Inner filter effect as a sensitive sensing platform for detection of nitrofurantoin using luminescent drug-based carbon nanodots

Al-Hashimi, Baraa; Omer, Khalid M.; Rahman, Heshu Sulaiman; Othman, Hemn Hassan

doi:10.1016/j.saa.2020.118835

Cited by 34 publications

(8 citation statements)

References 65 publications

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“…3a. 51–54 The XPS measurement showed that the synthesized CNDs are composed of carbon, oxygen, and nitrogen elements with an atomic percent of 53.7, 44.1, and 2.2, respectively. The deconvolution of the high-resolution C 1s core (Fig.…”

Section: Resultsmentioning

confidence: 99%

Green synthesis of fluorescent carbon nanodots from sage leaves for selective anticancer activity on 2D liver cancer cells and 3D multicellular tumor spheroids

Sawalha,

Abdallah,

Barham

et al. 2023

Nanoscale Adv.

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Section: Resultsmentioning

confidence: 99%

Green synthesis of fluorescent carbon nanodots from sage leaves for selective anticancer activity on 2D liver cancer cells and 3D multicellular tumor spheroids

Sawalha,

Abdallah,

Barham

et al. 2023

Nanoscale Adv.

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“…This recovered fluorescence is augmented with intrinsic fluorescence of folic acid, hence exhibits more fluorescence turn-on behavior with protamine in comparison with the behavior of other coexisting biomolecules. [36,37]…”

Section: Selectivity and Interferencementioning

confidence: 99%

Fluorescence “Turn‐Off‐On” Detection of Heparin and Protamine Based on Bovine Serum Albumin‐Stabilized Carbon Dots (BSA‐CDs)

Abraham,

Anand,

Madanan

et al. 2023

ChemNanoMat

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Heparin and protamine are two therapeutically significant biomolecules utilized in surgeries and extracorporeal therapy. Hence, real time monitoring of their concentration levels in body fluids is quite requisite. Herein, we developed, Bovine Serum Albumin stabilized carbon dots by a microwave‐assisted synthesis for the detection of heparin and protamine. Heparin has sulfate and carboxy groups that can interact with the positively charged surface amino groups of protamine through electrostatic interactions and hydrogen bonds. The blue fluorescence exhibited by BSA‐Carbon dots shows decrease in fluorescence emission on addition of negatively charged heparin. When cationic protein protamine is introduced to this system, the fluorescence is recovered due to electrostatic interaction with heparin. The system shows a Limit of detection (LOD) of 0.014 mM and 0.053 mM on addition of heparin and protamine respectively. The probe exhibited positive results with good selectivity and sensitivity towards other coexisting biomolecules and ions that appear in body fluids. The study was extended in biological matrix such as human serum and urine and found good recovery percentage in between 90–120%. The practical applicability was analyzed using a paper strip assay. Hence, a sensitive “turn‐off‐on” probe was effectively developed for the detection of heparin and protamine on a clinical basis.

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“…The inner filter effect (IFE) has some types, one is overlapping of the excitation spectra of the absorber of the emitter and absorption spectrum of the target molecule. 76,77 The interaction of FA with the Eu-MOF sensor causes a decrease in the fluorescence of the Eu-MOF. For more investigation we compared the UV-Vis absorption spectrum of FA with the excitation spectrum of the Eu-MOF.…”

Section: Sensing Mechanism Between Fa and Eu-mofmentioning

confidence: 99%

A red luminescent europium metal organic framework (Eu-MOF) integrated with a paper strip using smartphone visual detection for determination of folic acid in pharmaceutical formulations

Kayani

Omer

2022

New J. Chem.

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Inner filter effect as a sensitive sensing platform for detection of nitrofurantoin using luminescent drug-based carbon nanodots

Cited by 34 publications

References 65 publications

Green synthesis of fluorescent carbon nanodots from sage leaves for selective anticancer activity on 2D liver cancer cells and 3D multicellular tumor spheroids

Green synthesis of fluorescent carbon nanodots from sage leaves for selective anticancer activity on 2D liver cancer cells and 3D multicellular tumor spheroids

Fluorescence “Turn‐Off‐On” Detection of Heparin and Protamine Based on Bovine Serum Albumin‐Stabilized Carbon Dots (BSA‐CDs)

A red luminescent europium metal organic framework (Eu-MOF) integrated with a paper strip using smartphone visual detection for determination of folic acid in pharmaceutical formulations

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