Inner filter effect-based fluorescence assays toward environmental pesticides and antibiotics

Blocking Oxidase-Mimicking Activity-Driven Label-Free Photothermal and Colorimetric Synergistic Sensing for Intelligent Onsite Detection of Tetracycline Residues in Milk

“…Over the past few decades, the overuse of antibiotics in the poultry farming industry to ensure high yields has aroused increasing public concern about the quality and safety of animal-derived foodstuffs such as milk. − Thereinto, tetracycline antibiotics (TCs) are a class of tetraphenyl skeleton-based small molecular compounds that are recognized as one of the most low-cost and prominent broad-spectrum antibacterial activity, enabling them to be the most popular antibiotics against bacterial infections resulting from both Gram-positive and Gram-negative bacteria. − Nevertheless, the excessive use of TCs unavoidably poses a residual risk in animal-derived foodstuffs such as milk, resulting in food safety issues. Long-term exposure to TCA residues has been reported to cause a range of health problems such as gastrointestinal disorders, nephrotoxicity, allergies, and central nervous system disorders . More seriously, the misuse of TCs could cause the emergence of antibiotic-resistant bacteria to extremely threaten public health .…”

“…Long-term exposure to TCA residues has been reported to cause a range of health problems such as gastrointestinal disorders, nephrotoxicity, allergies, and central nervous system disorders. 7 More seriously, the misuse of TCs could cause the emergence of antibiotic-resistant bacteria to extremely threaten public health. 8 Although the official agencies of various countries have strictly stipulated the maximum allowable residual threshold of TCs in different animal-derived foodstuffs (e.g., the U.S. Food and Drug Administration has defined 676 nM as the maximum limit of residual TCs in milk), 9,10 the efficiently precise assay toward TCs still remains as one of the most important prerequisites in establishing reasonable TCs management, thereby reducing the threat of the residual TCs and safeguarding food safety.…”

A highly sensitive and selective fluorescent biosensor for breast cancer derived exosomes using click reaction of azide–CD63 aptamer and alkyne-polymer dots

“…16 In comparison, the fluorescence method offers numerous advantages, including ease of use, rapid response, simple instrumentation, high sensitivity, and excellent selectivity. 17–22…”

Rational Design of Carbon Dots Featuring High Spectral Overlap with Analyte for Effective Detection of Metronidazole via Inner Filter Effect

“…[7][8][9] Different from these response mechanisms, the inner filter effect (IFE), which refers to the emission intensity decrease caused by competitive light absorption of the analyte, does not require tedious synthesis or modification of fluorescence probe. [10,11] Thus, IFE-based fluorescence assays have recently attractive interests in sensing and detecting applications due to their low cost, simple operation, and good generality.…”