Inner filter effect (IFE) as a simple and selective sensing platform for detection of tetracycline using milk-based nitrogen-doped carbon nanodots as fluorescence probe

Al-Hashimi, Baraa; Omer, Khalid M.; Rahman, Heshu Sulaiman

doi:10.1016/j.arabjc.2020.02.013

Cited by 71 publications

(25 citation statements)

References 37 publications

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“…Fluorescence-based methods are widely used for sensing different analytes based on photoinduced electron transfer (PET), photoinduced charge transfer (PCT), fluorescence resonance energy transfer (FRET) and the inner filter effect (IFE). PET and PCT are intramolecular processes, whereas IFE and FRET are intermolecular processes, all of which involve energy transfer between at least two independent molecules [ 11 , 12 , 13 , 14 ]. We developed FRET-based sensors in previous studies and designed detection methods that reply via IFE in this study.…”

Section: Introductionmentioning

confidence: 99%

“…The IFE is a decrease in the fluorescence intensity of a fluorophore (donor) due to the absorption of the excitation/emission light by an absorber (acceptor). This occurs when the absorption spectrum of the absorber overlaps with the fluorescence excitation or emission spectrum of the fluorophore [ 14 ]. The IFE is classified as primary when the excitation beam is attenuated by the volume of the sample, and secondary when the emission of the fluorophore is absorbed by a molecule present in the solution [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

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“Turn on” Fluorescence Sensor of Glutathione Based on Inner Filter Effect of Co-Doped Carbon Dot/Gold Nanoparticle Composites

Kim

Park

2021

IJMS

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Glutathione (GSH) is a thiol that plays a significant role in nutrient metabolism, antioxidant defense and the regulation of cellular events. GSH deficiency is related to variety of diseases, so it is useful to develop novel approaches for GSH evaluation and detection. In this study we used nitrogen and phosphorus co-doped carbon dot-gold nanoparticle (NPCD–AuNP) composites to fabricate a simple and selective fluorescence sensor for GSH detection. We employed the reductant potential of the nitrogen and phosphorus co-doped carbon dots (NPCDs) themselves to form AuNPs, and subsequently NPCD–AuNP composites from Au3+. The composites were characterized by using a range of spectroscopic and electron microscopic techniques, including electrophoretic light scattering and X-ray diffraction. The overlap of the fluorescence emission spectrum of NPCDs and the absorption spectrum of AuNPs resulted in an effective inner filter effect (IFE) in the composite material, leading to a quenching of the fluorescence intensity. In the presence of GSH, the fluorescence intensity of the composite was recovered, which increased proportionally to increasing the GSH concentration. In addition, our GSH sensing method showed good selectivity and sensing potential in human serum with a limit of detection of 0.1 µM and acceptable results.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“Turn on” Fluorescence Sensor of Glutathione Based on Inner Filter Effect of Co-Doped Carbon Dot/Gold Nanoparticle Composites

Kim

Park

2021

IJMS

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“…The majority of the quenching in detecting drug using CD was explained using IFE. [83,88,90,91,93] Well spectral overlap between the absorption spectra of rifampicin with both the emission and excitation band made the authors confirm that the mechanism is either FRET or IFE. [74] A further investigation on the fluorescence lifetime revealed that both the CDs and CDrifampicin systems had a coincidental lifetime of about 7.82 ns, thereby confirming the mechanism as an IFE.…”

Section: Quenching Mechanismsmentioning

confidence: 98%

Recent Progress and Future Perspectives of Carbon Dots in the Detection, Degradation, and Enhancement of Drugs

Korah

Chacko

Abraham

et al. 2022

Part & Part Syst Charact

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for maximum solar energy conversion. Due to the broad light absorbance, photo luminescence (PL) properties, and elec tron transfer capability, CDs alone and as composites with other species can act as excellent candidates for the degradation of organic pollutants. CDs have a healthy competition between traditional semicon ductors in several aspects such as reduced cost, easy functionalization, biocompat ibility, highly tunable PL, inertness, and resistance to photobleaching, in which CDs are almost in the winning stage. [8,9] Drugs play an inevitable role in main taining human health and wellbeing. The harsh reality is that the high chem ical stability and low biodegradability of pharmaceuticals, along with an increase in consumption patterns, cause a signifi cant threat to aquatic life and the whole food chain. The active ingredients, pre servatives, radioactive components, and solvents used in the drug can act on unin tended targets. This hazardous material released to the environ ment due to various human activities are accumulative and can cause serious health issues to all living beings. [10,11] The sudden increase in the global emissions of antibiotics is attributed to their increasing overuse and misuse, along with the ineffective ness of existing degradation methods. It is a great relief that the CDs have the potential of detecting and degrading these phar maceuticals without hurting the green planet. It is essential to safeguard nature without causing everlasting scars and wounds.The detection of pharmaceuticals in drinking water necessi tates developing environmentfriendly methods and materials for their safe discharge. There are several reports of the syn thesis of CDs for the degradation and sensing of drugs. Further more, CDs have been used for the enhancement of the activity of antibiotics. Despite the growing focus on several other appli cations on CDs, there is no review giving special attention to the reported CDdrug relations in the literature. In this review, we have made a small step toward summarizing the interac tion between CDs and drugs, concentrating mainly on applica tions, including detection, degradation, and enhancement of drugs. The review is primarily divided into three sections after a brief note on CDs' history, synthesis approaches, and modifi cation methods. First section deals with the potential applica tion of CDs in detecting or sensing drugs. It is followed by the development of CD/photocatalyst composite for the photodeg radation of pharmaceutical products in the second section. The third section of the review is dedicated to the enhanced activity attained when CDs are conjugated with drugs.Carbon dots (CDs) are new types of nanoparticles with sizes less than 10 nm in diameter. CDs with their unique properties can detect, degrade, and surprisingly enhance drugs. This review focuses on three major aspects of CDdrug interactions: detection, degradation, and enhancement of drugs using CDs. The review begins with a brief account of the significant development milestones, the sy...

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“…Various approaches have been applied for preparing diverse types of CDs, e.g., laser ablation [65], solvothermal [66], hydrothermal synthesis [67], microwave-assisted [68], arc discharge [69], acidic oxidation [70], and more chemical and physical approaches [71,72]. Additionally, CDs display a desirable prospect for various applications, such as biological imaging [73], chemical and biosensing [74][75][76][77], targeted drug delivery [78], pharmaceutical analysis [79], and catalysis [80,81]. Carbon dots have been extensively reviewed in term of synthesis, physicochemical properties, as well as their potential applications.…”

Section: Carbon Dots As Nanothermometersmentioning

confidence: 99%

Carbon Dots as New Generation Materials for Nanothermometer: Review

Mohammed

Omer

2020

Nanoscale Res Lett

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Highly sensitive non-contact mode temperature sensing is substantial for studying fundamental chemical reactions, biological processes, and applications in medical diagnostics. Nanoscale-based thermometers are guaranteeing non-invasive probes for sensitive and precise temperature sensing with subcellular resolution. Fluorescence-based temperature sensors have shown great capacity since they operate as “non-contact” mode and offer the dual functions of cellular imaging and sensing the temperature at the molecular level. Advancements in nanomaterials and nanotechnology have led to the development of novel sensors, such as nanothermometers (novel temperature-sensing materials with a high spatial resolution at the nanoscale). Such nanothermometers have been developed using different platforms such as fluorescent proteins, organic compounds, metal nanoparticles, rare-earth-doped nanoparticles, and semiconductor quantum dots. Carbon dots (CDs) have attracted interest in many research fields because of outstanding properties such as strong fluorescence, photobleaching resistance, chemical stability, low-cost precursors, low toxicity, and biocompatibility. Recent reports showed the thermal-sensing behavior of some CDs that make them an alternative to other nanomaterials-based thermometers. This kind of luminescent-based thermometer is promising for nanocavity temperature sensing and thermal mapping to grasp a better understanding of biological processes. With CDs still in its early stages as nanoscale-based material for thermal sensing, in this review, we provide a comprehensive understanding of this novel nanothermometer, methods of functionalization to enhance thermal sensitivity and resolution, and mechanism of the thermal sensing behavior.

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Inner filter effect (IFE) as a simple and selective sensing platform for detection of tetracycline using milk-based nitrogen-doped carbon nanodots as fluorescence probe

Cited by 71 publications

References 37 publications

“Turn on” Fluorescence Sensor of Glutathione Based on Inner Filter Effect of Co-Doped Carbon Dot/Gold Nanoparticle Composites

“Turn on” Fluorescence Sensor of Glutathione Based on Inner Filter Effect of Co-Doped Carbon Dot/Gold Nanoparticle Composites

Recent Progress and Future Perspectives of Carbon Dots in the Detection, Degradation, and Enhancement of Drugs

Carbon Dots as New Generation Materials for Nanothermometer: Review

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