2020
DOI: 10.1101/2020.09.22.308973
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Innervated adrenomedullary microphysiological system to model prenatal nicotine and opioid exposure

Abstract: The transition to extrauterine life results in a critical surge of catecholamines necessary for increased cardiovascular, respiratory, and metabolic activity. The mechanisms mediating adrenomedullary catecholamine release are poorly understood, given the sympathetic adrenomedullary control systems' functional immaturity. Important mechanistic insight is provided by newborns delivered by cesarean section or subjected to prenatal nicotine or opioid exposure, demonstrating the impaired release of adrenomedullary … Show more

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