“…33 This wound should be treated surgically and as soon as possible, removing necrotic tissues 34,35,36 and providing wound bed preparation 37,38 using specific dressings 39,40 or negative pressure 41,42,43 (vacuum devices). Closure should be achieved as soon as possible with skin grafting, 44,45,46 local flaps, 47,48,49,50 or microsurgical flaps. 51,52,53 With these measures, we expect to reduce the significant personal and economic costs caused by the "diabetic foot"-the resulting longer stay in hospital, longer rehabilitation, and need for special care.…”