Innervation and myoepithelial arrangements in the submandibular salivary gland of ferret investigated by enzyme, catecholamine and filament histochemistry

Fletcher, David; Triantafyllou, Asterios; Scott, John

doi:10.1016/s0003-9969(99)00096-5

Cited by 14 publications

(2 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, an extensive intralobular nerve fibers network was evidenced embracing acini and ducts. Stellate cells with fine branching processes embracing acini were presumed as being myoepithelial cells, and a few spindle‐shaped basal cells, investing striated ducts, were demonstrated and were considered to confer mechanical stability and/or contractile ability (Fletcher et al, 1999). Myoepithelial cells are usually located around intercalated ducts (Ogawa, 2003) and extend their processes around the acini, but they have also been found in acini (Garrett and Parsons, 1973) or striated ducts (Garrett, 1967; Cutler et al, 1977).…”

Section: Discussionmentioning

confidence: 99%

Telocytes in Parotid Glands

Nicolescu

Bucur

Dincă

et al. 2011

The Anatomical Record

119

View full text Add to dashboard Cite

The parotid histological structure includes acinar, ductal, and myoepithelial cells, surrounded by a connective stromal component. The parotid stroma is mostly regarded as an inert shell, consisting of septa, which divide the parenchyma. Telocytes were recently identified as a new stromal cell type in various organs, including exocrine pancreas. We aimed to evaluate telocytes presence in parotid stroma and whether their topographical features might support an involvement in parotid function modulation. Serial ultrathin sections of human and rat parotid glands were studied and compared by transmission electron microscopy. Twodimensional concatenation of sequenced micrographs allowed the ultrastructural identification of parotid telocytes, with their specific long, thin, and moniliform prolongations (telopodes). Telocyte location appeared frequently as a strategic one, in close contact or vicinity of both secretory (acini and ducts) and regulatory (nerves and blood vessels) apparatuses. They were also found in the interacinar and the subductal stroma. Two previously reported telocyte markers (c-kit/CD117 and vimentin) were assayed by immunohistochemistry. Actin expression was also evaluated. Telocytes are making a network, especially by branching of their long telopodes. Elements of this telocyte network are interacting with each other (homocellular connections) as well as with other cell types (heterocellular connections). These interactions are achieved either by direct contact (stromal synapse), or mediated via shed microvesicles/exosomes. Since telocyte connections include both neurovascular and exocrine elements (e.g., acini and ducts), it is attractive to think that telocytes might mediate and integrate neural and/or vascular input with parotid function.

show abstract

Section: Discussionmentioning

confidence: 99%

Telocytes in Parotid Glands

Nicolescu

Bucur

Dincă

et al. 2011

The Anatomical Record

119

View full text Add to dashboard Cite

show abstract

“…In the submandibular gland (SMG) of humans (Garret 1966A;Hauser-Kronberger et al 1992;Salo et al 1993B;Kusakabe et al 1997) and some other mammalian species (Garret 1966B;Alm et al 1973;Soinila et al 1983Soinila et al , 1991Tobin et al 1990;Salo et al 1993A;Ekström et al 1996;Kusakabe et al 1996;Jia et al 1997;Fletcher et al 1999) adrenergic, cholinergic and peptidergic nerve fibres were discovered. Numerous peptides involved in the regulation of salivary functions, such as substance P (SP), neurokinin A (NKA), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY), as well as vasoactive intestinal polypeptide (VIP), were also detected with radioimmunoassay in the saliva of healthy human subjects (Dawidson et al 1997).…”

Section: Introductionmentioning

confidence: 99%

Co-expression of tyrosine hydroxylase, dopamine beta-hydroxylase and neuropeptide Y in the sympathetic neurons projecting to the submandibular gland in the sheep

Arciszewski¹,

Zacharko²,

Lalak³

2004

Anatomy and Embryology

View full text Add to dashboard Cite

Sympathetic neurons projecting to the ovine submandibular gland (SMG) from the superior cervical ganglion (SCG) and middle cervical ganglion (MCG) were identified using retrograde tracing with fluorescent dye (Fast Blue). Antibodies to tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DbetaH) and neuropeptide Y (NPY) were used to determine the immunochemical characteristics of SMG-innervating sympathetic neurons. Immunohistochemistry combined with the retrograde tracing revealed that the population of SMG-projecting neurons consist of four distinct sub-populations, but taking into account their possible different physiological properties only three major sub-populations can be distinguished. The vast majority of neurons in both ganglia are noradrenergic in nature (co-express TH and DbetaH). All examined TH-immunoreactive (IR) neurons also show immunoreactivity to DbetaH. Sub-population of noradrenergic neurons can be divided into NPY-IR and non-NPY-IR. Noradrenergic neurons expressing NPY may act as vasoconstrictors. The second sub-population of SMG projecting neurons in the ganglia studied consists of non-noradrenergic neurons (containing NPY, but not TH). It is known that these kinds of neurons may play a vasodilatory role. In both examined ganglia the third sub-population consists of non-TH-IR and non-NPY-IR neurons of unknown physiological function. Since no DbetaH immunoreactivity was found in any of TH- neurons these nerve cells can also be regarded as non-noradrenergic. It is possible that some neurons of the second as well as the third sub-population are cholinergic and some of them are non-noradrenergic/non-cholinergic in character.

show abstract

A perspective of comparative salivary and breast pathology. Part I: microstructural aspects, adaptations and cellular events

Triantafyllou

Hunt

Devaney

et al. 2013

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

This is the first part of a review comparing the pathology of salivary and mammary glands. Here, less obvious similarities and differences in functional histology and their influences on pathology are examined with emphasis on myoepithelial cells, stromal components, analogues of mucosa-associated lymphoid tissue, steroid receptors, and intraparenchymal cells of monocytic lineage. Particular cell phenotypes (oncocytic, apocrine, neuroendocrine and clear) are critically evaluated and responses to atrophy, infarction and fine-needle aspiration biopsy procedures are highlighted together with aspects of metaplasia, regeneration, ageing and microcalcification. Areas of controversy or uncertainty which may benefit from further investigations are also discussed.

show abstract

Innervation and myoepithelial arrangements in the submandibular salivary gland of ferret investigated by enzyme, catecholamine and filament histochemistry

Cited by 14 publications

References 45 publications

Telocytes in Parotid Glands

Telocytes in Parotid Glands

Co-expression of tyrosine hydroxylase, dopamine beta-hydroxylase and neuropeptide Y in the sympathetic neurons projecting to the submandibular gland in the sheep

A perspective of comparative salivary and breast pathology. Part I: microstructural aspects, adaptations and cellular events

Contact Info

Product

Resources

About