Innervation of the arterial wall and its modification in atherosclerosis

Chistiakov, Dmitry A.; Ashwell, Ken W.S.; Orekhov, Alexander N.; Bobryshev, Yuri V.

doi:10.1016/j.autneu.2015.06.005

Cited by 34 publications

(26 citation statements)

References 66 publications

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“…Does this mean that resident neuron-associated macrophages have adapted a generic myeloid cell pathway that senses lipid abnormalities to suit their interactions with nerves? Or, as a neuroscientist might be seduced to speculate, is Trem2+ macrophage expansion in any tissue to some extent dependent on neuronal abnormalities -which have been reported in the context of both obesity 42 and atherosclerosis 43 ?…”

Section: Discussionmentioning

confidence: 99%

A transcriptional toolbox for exploring peripheral neuro-immune interactions

Liang

Hore

Harley

et al. 2019

Preprint

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Correct communication between immune cells and peripheral neurons is crucial for the protection of our bodies. Its breakdown is observed in many common, often painful conditions, including arthritis, neuropathies and inflammatory bowel or bladder disease. Here, we have characterised the immune response in a mouse model of neuropathic pain using flow cytometry and cell-type specific RNA sequencing (RNA-seq). We found few striking sex differences, but a very persistent inflammatory response, with increased numbers of monocytes and macrophages up to 3½ months after the initial injury. This raises the question of whether the commonly used categorisation of pain into "inflammatory" and "neuropathic" is one that is mechanistically appropriate. Finally, we collated our data with other published RNA-seq datasets on neurons, satellite glial cells, macrophages and Schwann cells in naïve and nerve injury states. The result is a practical web-based tool for the transcriptional data-mining of peripheral neuroimmune interactions. Figure 8: At one week post PSNL, MHCII+/Ly6C-myeloid cells from sciatic nerve upregulate functions relating to interactions with other immune cells, in favour of more generic pro-inflammatory and homeostatic activities.A) STRING network analysis reveals that 77 of 186 genes upregulated in ipsilateral MHCII+ macrophages at adj. p < 0.05 are likely to be functionally connected with overrepresented processes including antigen presentation, regulation of lymphocytes and myeloid cell activation. B) Conversely, 41 of 93 significantly downregulated genes formed a network that includes transcripts relating to pro-inflammatory function (TNF, complements), regulation of angiogenesis and canonical macrophage markers, like CD163 typically found in resident macrophages. See Suppl. Table 5 for differential expression tables.

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Section: Discussionmentioning

confidence: 99%

A transcriptional toolbox for exploring peripheral neuro-immune interactions

Liang

Hore

Harley

et al. 2019

Preprint

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“…[3,10] Повышение активности СНС увеличивает вазоконстрикцию, стимулирует накопление в стенке сосуда модифицированных липопротеинов, индуцирует эндотелиальную дисфункцию и ремоделирование. [11] С увеличением симпатической гиперактивности связано формирование метаболического синдрома. [12] Гиперактивность симпатической нервной системы вызывает воспалительные реакции [13].…”

Section: таблица 1 соотношение просвета брюшного отдела аорты к стенкеunclassified

Effect of Long-Term Vagotonia on Structural Changes in the Wall of Abdominal Aorta During Immobilization Stress in Experimental Study

Gavreliuk¹,

Levenets²

2018

Act. Probl. of the Modern Med.

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This work covers current questions on studying structural changes in the wall of the abdominal aorta during the modelled long-term immobilization stress against vagotonia. The purpose of this study was to reveal the effect of prolonged vagotonia on the structure of the wall of the abdominal aorta in rats in the experiment. The studies were performed on three comparable groups of hundred-day Wistar rats, which were exposed to immobilization stress and vagotonia for a period of 10 days. Immobilization was chosen as a method to induce stress model. The rats were placed into a special plastic box, in this way limiting their movements for four hours at room temperature. Vagotonia was modelled by the administration of pyridostigmine bromide, reversible anticholinesterase. Histological preparations of the abdominal aorta were studied by x40, x100, x400 magnification using the Primo Star 5 microscope (Carl Zeiss, FRG) followed by photography of microscopic images. Computer morphometry was performed with x100 and x400 magnification and then the image were displayed on the computer monitor using the DVR and AxioVision image analysis software (Rel.4.8.2) in μm. We assessed the thickness of the subendothelial layer, and namely an internal elastic membrane and media. The ratio of the extent of the abdominal aorta lumen to the vascular wall was calculated in the Adobe Photoshop program by the A. A. Glagoliev method through overlaying of point grids on sections, the results were converted into percentages. The studies were carried out in five fields of five different sections in each rat. The results of the variation analysis of the morphological data obtained have revealed some features of restructuring the vascular wall of the abdominal aorta due to prolonged immobilization stress accompanied by vagotonia. It has been found out that prolonged exposure of hundred-day Wistar rats to immobilization stress leads to a decrease in thickness and certain morphological changes in all layers of the abdominal aorta wall and a decrease in the percentage of the component of the vessel wall. When accompanied by prolonged immobilization and vagotonia, preservation of the endothelial layer of the abdominal aorta was observed against the background of a decrease in intimal thickness and degenerative cell changes, as well as media thickening and focal changes in adventitia.

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“…The main factors on the pathogenesis of atherosclerosis come from the arterial lumen, such as inflammation (Ross, 1999;Folsom, 2008;Ammirati et al, 2015;Balta et al, 2016), but the vascular function can also be impaired from the outside of vessels. Since the autonomic nervous system (ANS) innervates vascular walls, regulating wall contractility and tension, alterations in this control manifest as detrimental effects on endothelial and vascular function, favouring atherogenesis (Chistiakov et al, 2015;Grassi et al, 2015). Impairments in the ANS and vascular function frequently coexist in the pathogenesis of different cardiovascular diseases, such as myocardial infarction (Gautier et al, 2007;Khandoker et al, 2017;Sessa et al, 2018) and stroke (Bots et al, 1996;O'Leary et al, 1999;Kwon et al, 2008), reflecting a complexity relationship.…”

Section: Introductionmentioning

confidence: 99%

Relationship between heart rate variability and carotid intima‐media thickness in the Brazilian Longitudinal Study of Adult Health – ELSA‐Brasil

Hoshi

Santos

Dantas

et al. 2020

Clin Physio Funct Imaging

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Background Both increased carotid intima-media thickness (cIMT) and low heart rate variability (HRV) have been associated with cardiovascular mortality and morbidity. Thus, the aim of this study was to investigate whether cardio autonomic alterations are accompanied or not by subclinical atherosclerosis in participants of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Methods cIMT measures and 5-min HRV analyses were performed in apparently healthy adults. Heart rate variability was evaluated by linear time and frequency domain analyses. cIMT was defined as the average between the mean left and mean right cIMT values and was analysed as continuous and categorized variables (P≥75 or P<75). Multiple linear models using continuous variables and multivariate logistic regression with categorized cIMT and HRV quartiles were performed. Results Out of 7256 participants eligible for analyses, 23Á4% presented cIMT ≥ 75th percentile. Heart rate variability variables were reduced in cIMT ≥ P75 in comparison with cIMT < P75: SDNN 33Á0 versus 37Á0 ms, P<0Á001; RMSSD 22Á0 versus 26Á0 ms, P<0Á001; LF 191Á0 versus 260Á0 ms 2 , P<0Á001; HF 164Á0 versus 238Á5 ms 2 , P<0Á001. In crude analysis, an increased odds ratio for cIMT ≥ P75 was verified within the lowest two quartiles of LF and HF, but significances did not remain after adjustments for anthropometric and clinical variables.Conclusions Considering the entire sample, subjects with cIMT ≥ P75 presented lower HRV values, but no independent relationships were detected between cIMT and HRV after multivariate adjustment.A previously validated, comprehensive set of questionnaires, clinical measurements and laboratory tests were carried out. Sociodemographic factors and previous medical history were

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Innervation of the arterial wall and its modification in atherosclerosis

Cited by 34 publications

References 66 publications

A transcriptional toolbox for exploring peripheral neuro-immune interactions

A transcriptional toolbox for exploring peripheral neuro-immune interactions

Effect of Long-Term Vagotonia on Structural Changes in the Wall of Abdominal Aorta During Immobilization Stress in Experimental Study

Relationship between heart rate variability and carotid intima‐media thickness in the Brazilian Longitudinal Study of Adult Health – ELSA‐Brasil

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