Innervation of the Mature Human Pelvis

Marani, Enrico; Koch, Wijnand F.R.M.

doi:10.1007/978-3-642-40006-3_14

Cited by 1 publication

(1 citation statement)

References 28 publications

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“…Although there have been no direct ties between PGBD5 and POP in the literature, it is of interest that several eQTL have been shown to alter expression of this gene in the tibial nerve [ 39 ]. The tibial nerve originates from the same lumbar and sacral nerves (L5 through S3) which also innervate the pelvic floor [ 45 ]. Studies suggest that neuro-modulation through percutaneous or posterior tibial nerve stimulation, may be beneficial in alleviating symptoms associated with pelvic floor disorders including fecal and urinary incontinence [ 46 – 48 ].…”

Section: Discussionmentioning

confidence: 99%

Genetic Determinants of Pelvic Organ Prolapse among African American and Hispanic Women in the Women’s Health Initiative

Giri

Ward

et al. 2015

PLoS ONE

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Current evidence suggests a multifactorial etiology to pelvic organ prolapse (POP), including genetic predisposition. We conducted a genome-wide association study of POP in African American (AA) and Hispanic (HP) women from the Women’s Health Initiative Hormone Therapy study. Cases were defined as any POP (grades 1–3) or moderate/severe POP (grades 2–3), while controls had grade 0 POP. We performed race-specific multiple logistic regression analyses between SNPs imputed to 1000 genomes in relation to POP (grade 0 vs 1–3; grade 0 vs 2–3) adjusting for age at diagnosis, body mass index, parity, and genetic ancestry. There were 1274 controls and 1427 cases of any POP and 317 cases of moderate/severe POP. Although none of the analyses reached genome-wide significance (p<5x10-8), we noted variants in several loci that met p<10−6. In race-specific analysis of grade 0 vs 2–3, intronic SNPs in the CPE gene (rs28573326, OR:2.14; 95% CI 1.62–2.83; p = 1.0x10-7) were associated with POP in AAs, and SNPs in the gene AL132709.5 (rs1950626, OR:2.96; 95% CI 1.96–4.48, p = 2.6x10-7) were associated with POP in HPs. Inverse variance fixed-effect meta-analysis of the race-specific results showed suggestive signals for SNPs in the DPP6 gene (rs11243354, OR:1.36; p = 4.2x10-7) in the grade 0 vs 1–3 analyses and for SNPs around PGBD5 (rs740494, OR:2.17; p = 8.6x10-7) and SHC3 (rs2209875, OR:0.60; p = 9.3x10-7) in the grade 0 vs 2–3 analyses. While we did not identify genome-wide significant findings, we document several SNPs reaching suggestive statistical significance. Further interrogation of POP in larger minority samples is warranted.

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