Introduction In a recent detailed study (1) concerning policy-relevant, theoretical approaches towards stimulating innovativeness in regions (Cooke et al, 2006), the idea that``Regional innovation systems [RISs] have played and will continue to play a strategic role in promoting the innovativeness and competitiveness of regions'' (page 16) was stressed. The authors arrived at this conclusion on the basis of a thorough examination of other well-known theoretical concepts including clusters, learning regions, competitive advantage, and the triple helix. The primary thesis of this study is that a region is a suitable platform for the mobilization of key innovation actors and that, with appropriate proinnovation support, regional advantage can be actively constructed even in less successful regions. Therefore, the authors of this approach coin the phrase`constructing regional advantage'. In a response to Bathelt's critique that the RIS approach runs the risk of underestimating the importance of institutions, negotiated and defined at the level of the nation-state (Bathelt, 2003), the authors emphasize the necessity of employing a multilevel approach to innovation and governance and that RISs are open, socially constructed, and linked to global, national, and other regional systems of innovation, within a multilevel governance perspective (Cooke, 2006). Within this context the extensive literature on systems of innovation (Edquist, 1997; Freeman, 1987; Lundvall, 1992) can be summarized as largely emphasizing that innovations are the result of the continuous interaction of firms with each other and with other knowledge-generating organizations in the system. Therefore, the main focus of the innovation system (IS) approach is the operation of the system and the complex interactions that take place among the different organizations and institutions in the system.