INNOVATION-BASED APPROACH IN RECONSTRUCTION OF REDUCED JAW ALVEOLAR RIDGE BONE USING CELL REGENERATION TECHNOLOGIES , Dmitry Domenyuk3

Abstract

This study was performed to assess the size, structure and functional features of the reconstructed alveolar ridge using the autologous stromal and vascular fraction of adipose tissue (SVF-AT) up to 10 years. Materials and methods. This study evaluates 141 patients (61 males, 80 females) aged range 45 to 78 years (Moda 57 years) with jaw alveolar ridge regression. 112 osteoplastic surgical procedures in the test (TG) were performed using SVF-AT with subsequent placement of 297 dental implants in the reconstructed ridge; in the control (CG)-117 osteoplastic surgical procedures were performed using generally approach with subsequent placement of 323 dental implants. The alveolar ridge size and reconstructed bone features was evaluated in terms of up to 10 years. Histologic and histomorphometric study of 27 reconstructed bonecor-biopsies was conducted. The data were statistically analyzed. Results. The results of this comparative study confirm the advantages of the proposed cell-potentiated approach over the current generally accepted methods for the reconstruction of the alveolar jaw ridge. The use of SVF-AT with osteoplastic material allows to achieve new and sufficient bone growth with an insignificant risk of complications and reoperations (8% and 21% of cases in TG and CG, respectively, p = 0,231), optimal morphological properties of the regenerate (40,14 ± 3,36 and 24,23 ± 2,63% of bone tissue in TG and KG respectively, p = 0,001), that provides reliable fixture integration in the reconstructed alveolar ridge and high efficiency of the implant-supported restorations (97% and 88% in TG and KG, respectively, up to 10 years, p ˂0,001). Conclusion. The proposed innovative approach can be recommended as a basis for a valid surgical protocol with a pronounced of the jaw bones regression transformation. This will allow more successful and predictable use the implantsupported prosthetic restorations in reconstructed ridges in this category of patients. K E Y w o r d s-regression bone transformation, stromal and vascular fraction of adipose tissue, reconstruction of the alveolar ridge, dental implantation

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