This study analyzes the cross-country e¤ects of in ‡ation on innovation and international technology transfer via cash-in-advance (CIA) constraints on R&D investment. We consider a scale-invariant North-South quality-ladder model that features innovative R&D in the North and adaptive R&D in the South. We …nd that a higher in ‡ation in the South causes a permanent decrease in the rate of international technology transfer, a permanent increase in the North-South wage gap, and a temporary decrease in the rate of Northern innovation. A higher in ‡ation in the North causes a temporary decrease in the rate of Northern innovation, a permanent decrease in the North-South wage gap, and an ambiguous e¤ect on the rate of international technology transfer depending on the relative size of the two economies. We also calibrate the model to China-US data and …nd that the cross-country welfare e¤ect of in ‡ation is quantitatively signi…cant from the North to the South, but not from the South to the North. Speci…cally, permanently decreasing in ‡ation to achieve the Friedman rule in the US leads to a welfare gain of 3.28% in the US and a welfare gain of 3.31% in China. However, permanently decreasing in ‡ation to achieve the Friedman rule in China leads to much smaller welfare gains of 0.34% in China and 0.17% in the US.JEL classi…cation: O30, O40, E41, F43