Nowadays companies are in worldwide competition for innovations which are essential to ensure their competitiveness and consequently their business success. Information Technology (IT) plays an important role in this context. Thus, it is expected from IT organizations to provide an own value contribution to the corporate performance by delivering innovations. This raises the questions how chief information officers (CIO) can facilitate the generation of IT-enabled business innovations. As a result of our research, we identified 22 factors concerning the relevant aspects in IT organizations-IT projects, IT systems, IT processes, IT services, IT personnel and aspects referring to the organizational structure. These factors help CIOs to foster the generation of IT-enabled innovations and therefore should be considered in the management of IT organizations.