Innovation for infection prevention and control—revisiting Pasteur's vision

Birgand, Gabriel; Ahmad, Raheelah; Bulabula, Andre N H; Singh, Sanjeev; Bearman, Gonzalo; Castro-Sánchez, Enrique; Holmes, Alison

doi:10.1016/s0140-6736(22)02459-x

Cited by 11 publications

(5 citation statements)

References 99 publications

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“…Other attempts made recently for fabrication of LGC as implants or surface coatings that do not possess antimicrobial property 6 1,38–41 . However, for implant applications, there is an immense need for an antimicrobial characteristic due to associated risk of hospital acquired infections in postimplantation 42 …”

Section: Resultsmentioning

confidence: 99%

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Tailoring antimicrobial characteristic and mechanical behavior with silver in leucite–glass–ceramics for hard tissue engineering

Singh,

Gurjar,

Bhatia

et al. 2023

Int J Applied Ceramic Tech

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Leucite glass–ceramics are excellent dental restorative materials, but they have relatively poor fracture toughness and high hardness, which leads to lower damage tolerance and counter‐tooth wear, respectively. These materials are also susceptible to bacterial infections and biofilm formations. Here, we report a versatile material leucite–silver‐based glass–ceramic to address the aforementioned shortcomings. Silver was incorporated in leucite (K2O·Al2O3·4SiO2) glass–ceramic to improve the fracture toughness, reduce hardness, and impart antibacterial characteristics. Silver (2, 5, 10, and 15 wt.%) was added into the leucite glass matrix by two approaches, that is, using silver nanoflakes (AgNFs) and using precursor (AgNO3), via thermal decomposition, followed by a sintering process. The incorporation of silver was confirmed by X‐ray diffraction, transmission electron microscopy, and energy‐dispersive spectroscopy. Results showed that the hardness of the leucite‐silver composite material was reduced by 30% and indentation toughness improved by 47% as determined by Vickers indentation. Antibacterial characteristics of the material were investigated against Staphylococcus aureus and Escherichia coli bacteria. Scanning electron microscopy was done to see the morphology of damaged bacteria and colonies. Further, antibacterial activity was quantified using the colony formation unit counting method. All the samples showed antibacterial activity and the sample with the highest silver content, that is, 15 wt.% showed maximum potential to damage the bacteria. Inductively coupled plasma‐atomic emission spectroscopy analysis is done in phosphate buffer saline solution to quantify the amount of silver leached out from the leucite‐silver glass–ceramic samples. It was seen that the cumulative leached‐out silver over 3 days was less than 4 μg/cm2 which is well within the daily tolerance limit (5 μg/kg/day) of silver for the human body. Further, to confirm the cell viability, a cytocompatibility test is performed using L929 fibroblast and AW8507 oral cell lines. Cell viability of more than 80% was achieved, suggesting their suitability for biomedical applications. It is believed that the developed material can be a potential candidate for various applications like dental restorations, implants, and coating material for different substrates (SS 304, SS 316, Ti6Al4V, etc.) to protect them from bacterial infections and biofilm formation, etc.

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Section: Resultsmentioning

confidence: 99%

“…61,38-41 However, for implant applications, there is an immense need for an antimicrobial characteristic due to associated risk of hospital acquired infections in postimplantation. 42…”

Section: Silver Addition In Leucite Glass-ceramic Inhibited Bacterial...mentioning

confidence: 99%

Tailoring antimicrobial characteristic and mechanical behavior with silver in leucite–glass–ceramics for hard tissue engineering

Singh,

Gurjar,

Bhatia

et al. 2023

Int J Applied Ceramic Tech

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“…Furthermore, investing in new infection control technologies and protocols in neonatal care units is essential. This includes improved sterilization methods, the use of antimicrobial surfaces, and the integration of real-time infection tracking systems [31,32]. Finally, implementing comprehensive surveillance systems that use artificial intelligence and machine learning to predict and detect outbreaks [33,34] of P. agglomerans infections in real-time seems an innovative approach that might help in swiftly managing and containing infections.…”

Section: Discussionmentioning

confidence: 99%

Pantoea agglomerans Infection in Neonates: A Systematic Review of Case Reports

Nanou,

Tzoraki,

Apostolidi

et al. 2024

Cureus

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“…In recent years, the landscape of infection prevention in gynaecological surgery has been marked by notable innovations, each aimed at mitigating postoperative infections. These advancements underscore the field's commitment to improving patient outcomes and revolutionizing how infections are managed in gynaecology [ 75 ].…”

Section: Reviewmentioning

confidence: 99%

From Prevention to Management: Understanding Postoperative Infections in Gynaecology

Ronghe,

Modak,

Gomase

et al. 2023

Cureus

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This narrative review examines the multifaceted realm of postoperative infections in gynaecology, addressing their significance, types, risk factors, prevention, management, and emerging trends. Postoperative infections, encompassing surgical site infections, urinary tract infections, and pelvic inflammatory disease, pose considerable challenges in patient care, warranting comprehensive exploration. Strategies for prevention include preoperative patient assessment, antimicrobial prophylaxis, and aseptic techniques. Intraoperative measures encompass infection control and instrument sterilization, while postoperative care involves wound management and early infection detection. Diagnostic tools, including blood tests, imaging, and microbiological cultures, aid in timely identification. Management strategies encompass antibiotic therapy, surgical interventions, supportive care, and addressing complications. The review underscores the necessity of personalized approaches, multidisciplinary collaboration, and innovative technologies in future infection management. It calls for ongoing research, heightened awareness, and meticulous care to minimize the impact of postoperative infections and optimize patient outcomes.

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Innovation for infection prevention and control—revisiting Pasteur's vision

Cited by 11 publications

References 99 publications

Tailoring antimicrobial characteristic and mechanical behavior with silver in leucite–glass–ceramics for hard tissue engineering

Tailoring antimicrobial characteristic and mechanical behavior with silver in leucite–glass–ceramics for hard tissue engineering

Pantoea agglomerans Infection in Neonates: A Systematic Review of Case Reports

From Prevention to Management: Understanding Postoperative Infections in Gynaecology

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