The article explores sustainable development in terms of the green growth concept relative to the Ural-Siberian macro-region of Russia. To implement the principles of sustainable development in conditions of uncertainty, environmental preservation and economic progress, the main directions, problems and prospects have been analysed. The study aims to assess the potential for sustainable development of the Ural-Siberian macro-region and analyse the most promising directions in the sphere of the green economy. The results and conclusions of the article can be useful for formulating regional sustainable socio-economic development strategies with regard to the green growth principles.