Innovation in the Development of Synthetic and Natural Ocular Drug Delivery Systems for Eye Diseases Treatment: Focusing on Drug-Loaded Ocular Inserts, Contacts, and Intraocular Lenses

Pelusi, Letizia; Mandatori, Domitilla; Mastropasqua, Leonardo; Agnifili, Luca; Allegretti, Marcello; Nubile, Mario; Pandolfi, Assunta

doi:10.3390/pharmaceutics15020625

Cited by 8 publications

(3 citation statements)

References 111 publications

(117 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based upon solubility, they can be classified as insoluble (osmotic, diffusion, contact lens); soluble (based on natural polymers, e.g., collagen, or based on synthetic or semi-synthetic polymers, e.g., cellulose derivatives, such as HPMC, HPC, MC, etc. ); and bioerodible [ 158 ].…”

Section: Innovative Drug Delivery Systemsmentioning

confidence: 99%

Innovative Strategies for Drug Delivery to the Ocular Posterior Segment

et al. 2023

View full text Add to dashboard Cite

Innovative and new drug delivery systems (DDSs) have recently been developed to vehicle treatments and drugs to the ocular posterior segment and the retina. New formulations and technological developments, such as nanotechnology, novel matrices, and non-traditional treatment strategies, open new perspectives in this field. The aim of this mini-review is to highlight promising strategies reported in the current literature based on innovative routes to overcome the anatomical and physiological barriers of the vitreoretinal structures. The paper also describes the challenges in finding appropriate and pertinent treatments that provide safety and efficacy and the problems related to patient compliance, acceptability, effectiveness, and sustained drug delivery. The clinical application of these experimental approaches can help pave the way for standardizing the use of DDSs in developing enhanced treatment strategies and personalized therapeutic options for ocular pathologies.

show abstract

Section: Innovative Drug Delivery Systemsmentioning

confidence: 99%

Innovative Strategies for Drug Delivery to the Ocular Posterior Segment

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Ocular inserts (OIs) are synthetic medical devices containing drugs that are delivered to the surface of the eye using a sustained release mechanism [ 41 , 45 ]. They are extremely thin to reduce the unpleasant sensations that patients may experience, and they are also sterile, which is a critical requirement for ocular drugs.…”

Section: Ocular Insertsmentioning

confidence: 99%

Technological Advances in a Therapy of Primary Open-Angle Glaucoma: Insights into Current Nanotechnologies

Zembala,

Forma,

Zembala

et al. 2023

JCM

View full text Add to dashboard Cite

Glaucoma is a leading cause of irreversible blindness and is characterized by increased intraocular pressure (IOP) and progressive optic nerve damage. The current therapeutic approaches for glaucoma management, such as eye drops and oral medications, face challenges including poor bioavailability, low patient compliance, and limited efficacy. In recent years, nanotechnology has emerged as a promising approach to overcome these limitations and revolutionize glaucoma treatment. In this narrative review, we present an overview of the novel nanotechnologies employed in the treatment of primary open-angle glaucoma. Various nanosystems, including liposomes, niosomes, nanoparticles, and other nanostructured carriers, have been developed to enhance the delivery and bioavailability of antiglaucoma drugs. They offer advantages such as a high drug loading capacity, sustained release, improved corneal permeability, and targeted drug delivery to the ocular tissues. The application of nanotechnologies in glaucoma treatment represents a transformative approach that addresses the limitations of conventional therapies. However, further research is needed to optimize the formulations, evaluate long-term safety, and implement these nanotechnologies into clinical practice. With continued advancements in nanotechnology, the future holds great potential for improving the management and outcomes of glaucoma, ultimately preserving vision and improving the lives of millions affected by this debilitating disease.

show abstract

“…This technology is particularly beneficial for treating chronic eye conditions like glaucoma, dry eye syndrome, and infections, as it maintains a therapeutic level of the drug in the tear film for extended periods, ensuring more effective treatment. Additionally, drug-loaded contact lenses improve patient compliance by reducing the frequency of drug administration and eliminating the discomfort often associated with eye drops [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Koenzi̇m Q10 Yüklü Mi̇sel İçeren Kontakt Lensleri̇n Hazirlanmasi Ve i̇n-Vi̇tro Karakteri̇zasyonu

ERGİN

2023

Ankara Ecz. Fak. Derg.

View full text Add to dashboard Cite

Objective: Coenzyme Q10 (CoQ10) offers potential therapeutic benefits for ocular health, yet faces challenges of poor solubility and bioavailability when applied to the eye. This study aimed to enhance CoQ10 delivery using contact lenses by incorporating CoQ10-loaded polymeric micelles, using Pluronic F127 and solvent evaporation technique. Material and Method: Polymeric micelles encapsulating CoQ10 were produced via solvent evaporation with Pluronic F127. Commercial contact lenses were subsequently loaded with these micelles. Characterization of the loaded lenses included assessments of light transmittance, swelling behavior, and drug release profile under non-sink conditions, simulating the constraints of the ocular surface. Result and Discussion: The unloaded lenses exhibited a light transmittance of 91.78±3.29% and swelling percentage of 47.51±4.45% while micelle-loaded lenses demonstrated high light transmittance levels (95.31±0.80%), ensuring optical clarity. Swelling studies showed a slight increase in size to 48.1±4.4%. The lenses effectively encapsulated 403.6±21.8 µg of CoQ10. In vitro release profile exhibited controlled release over six hours, indicating potential for sustained drug delivery. These results highlight the feasibility of micelle-loaded contact lenses for efficient ocular drug delivery, warranting further exploration into their long-term effectiveness and safety.

show abstract

Innovation in the Development of Synthetic and Natural Ocular Drug Delivery Systems for Eye Diseases Treatment: Focusing on Drug-Loaded Ocular Inserts, Contacts, and Intraocular Lenses

Cited by 8 publications

References 111 publications

Innovative Strategies for Drug Delivery to the Ocular Posterior Segment

Innovative Strategies for Drug Delivery to the Ocular Posterior Segment

Technological Advances in a Therapy of Primary Open-Angle Glaucoma: Insights into Current Nanotechnologies

Koenzi̇m Q10 Yüklü Mi̇sel İçeren Kontakt Lensleri̇n Hazirlanmasi Ve i̇n-Vi̇tro Karakteri̇zasyonu

Contact Info

Product

Resources

About