Innovation of the Parasitic Cycle of Coccidioides spp.

Muñoz-Hernández, Bertha; Rivera, Ma. De los Angeles Martínez; Palma-Cortés, Gabriel; Manjarrez, María Eugenia

doi:10.5772/32334

Cited by 4 publications

(7 citation statements)

References 41 publications

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“…AlN and AlP band structures computed for 8 bands are presented in figure 3. The overall shape of bands in L-Γ-X direction is the same as in the reported earlier LDA studies [13,6] but the MBJLDA band-gaps are significantly bigger. The results of indirect (Γ-X) and direct band-gaps are gathered in table 2.…”

Section: Resultssupporting

confidence: 83%

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Origin of band-gap bowing in wurtzite AlN1−P alloys

Winiarski

2016

Scripta Materialia

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Section: Resultssupporting

confidence: 83%

“…The electronic and structural properties of ZB AlN and AlP have been extensively investigated ab initio [5,6,7,8,9,10,11,12,13,14,15,16], in the framework of the density functional theory. In this work we focus on the structural and electronic properties of ZB AlN 1−x P x alloy.…”

Section: Introductionmentioning

confidence: 99%

Origin of band-gap bowing in wurtzite AlN1−P alloys

Winiarski

2016

Scripta Materialia

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“…Although parasitic mycelial forms of Coccidioides spp. have been found in ≥50% of patients with chronic cavitary coccidioidomycosis, these are not diagnosed by themselves, when only cytological and histopathological methods are used; thus, it is advisable to research spherules and support this diagnosis by fungus culture or immunological test [ 7 , 8 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

Parasitic polymorphism of Coccidioidesspp

et al. 2014

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BackgroundCoccidioides spp. is the ethiological agent of coccidioidomycosis, an infection that can be fatal. Its diagnosis is complicated, due to that it shares clinical and histopathological characteristics with other pulmonary mycoses. Coccidioides spp. is a dimorphic fungus and, in its saprobic phase, grows as a mycelium, forming a large amount of arthroconidia. In susceptible persons, arthroconidia induce dimorphic changes into spherules/endospores, a typical parasitic form of Coccidioides spp. In addition, the diversity of mycelial parasitic forms has been observed in clinical specimens; they are scarcely known and produce errors in diagnosis.MethodsWe presented a retrospective study of images from specimens of smears with 15% potassium hydroxide, cytology, and tissue biopsies of a histopathologic collection from patients with coccidioidomycosis seen at a tertiary-care hospital in Mexico City.ResultsThe parasitic polymorphism of Coccidioides spp. observed in the clinical specimens was as follows: i) spherules/endospores in different maturation stages; ii) pleomorphic cells (septate hyphae, hyphae composed of ovoid and spherical cells, and arthroconidia), and iii) fungal ball formation (mycelia with septate hyphae and arthroconidia).ConclusionsThe parasitic polymorphism of Coccidioides spp. includes the following: spherules/endospores, arthroconidia, and different forms of mycelia. This knowledge is important for the accurate diagnosis of coccidioidomycosis. In earlier studies, we proposed the integration of this diversity of forms in the Coccidioides spp. parasitic cycle. The microhabitat surrounding the fungus into the host would favor the parasitic polymorphism of this fungus, and this environment may assist in the evolution toward parasitism of Coccidioides spp.

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“…Muñoz-Hernández and colleagues have reported that innate immunity protects healthy individuals from Coccidioides infection in 70% of cases (123). This percentage is an intriguing contention; however, the exact derivation has not been elucidated and may merit further investigation.…”

Section: Innate Immunitymentioning

confidence: 97%

Early Events in Coccidioidomycosis

et al. 2019

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SUMMARY Since its description nearly 130 years ago, hundreds of studies have deepened our understanding of coccidioidomycosis, also known as valley fever (VF), and provided useful diagnostic tests and treatments for the disease caused by the dimorphic fungi Coccidioides spp. In general, most of the literature has addressed well-established infections and has described patients who have experienced major complications. In contrast, little attention has been given to the earliest consequences of the pathogen-host interaction and its implications for disease manifestation, progression, and resolution. The purpose of this review is to highlight published studies on early coccidioidomycosis, identify gaps in our knowledge, and suggest new or former research areas that might be or remain fertile ground for insight into the early stages of this invasive fungal disease.

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Innovation of the Parasitic Cycle of Coccidioides spp.

Cited by 4 publications

References 41 publications

Origin of band-gap bowing in wurtzite AlN1−P alloys

Origin of band-gap bowing in wurtzite AlN1−P alloys

Parasitic polymorphism of Coccidioidesspp

Early Events in Coccidioidomycosis

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