Innovations in 3D printing: a 3D overview from optics to organs

Schubert, Carl; Langeveld, Mark Christensen van; Donoso, Larry A.

doi:10.1136/bjophthalmol-2013-304446

Cited by 618 publications

(365 citation statements)

References 11 publications

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“…10 ml of saturated aqueous CoCl2 was added to 40mL of isopropyl alcohol as previously published [1]. The 3D-printed cuvette was connected to a water bath placed into the UV visible machine and mixture absorbance between 400 -800 nm was measured at temperatures between 15°C -45°C in increments, leaving 5 minutes for thermal equilibration between measurements.…”

Section: Determination Of the Thermochromic Shift Of Mixtures Of Coclmentioning

confidence: 99%

“…These FDM 3D-printers allow end users to design, test and construct bespoke 3D-fabricated plastic prototypes targeted to their own individual applications [1]. Researchers in the chemical and biomedical sciences have made bespoke integrated reactionware [2][3][4][5][6][7], DNA adhesives [8], inserts for cuvettes [9] or X-ray absorption spectroscopy [10] that enable spectroelectrochemistry to be performed, surgical models and synthetic organs [11] and microfluidic pumps [12].…”

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confidence: 99%

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A low volume 3D-printed temperature-controllable cuvette for UV visible spectroscopy

Pisaruka

Dymond

2016

Analytical Biochemistry

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We report the fabrication of a 3D-printed water-heated cuvette that fits into a standard UV visible spectrophotometer. Full 3D-printable designs are provided and 3D-printing conditions have been optimised to provide options to print the cuvette in either acrylonitrile butadiene styrene or polylactic acid polymers, extending the range of solvents that are compatible with the design. We demonstrate the efficacy of the cuvette by determining the critical micelle concentration of sodium dodecyl sulphate at 40°C, the molar extinction coefficients of cobalt nitrate and dsDNA and by reproducing the thermochromic UV visible spectrum of a mixture of cobalt chloride, water and propan-2-ol. Analytical Biochemistry 510 (2016) 52-55 Accepted 15 July 2016In recent years there has been a rapid expansion in the number and quality of commercially available, affordable, fused deposition modelling (FDM) 3D-printers. These FDM 3D-printers allow end users to design, test and construct bespoke 3D-fabricated plastic prototypes targeted to their own individual applications [1]. Researchers in the chemical and biomedical sciences have made bespoke integrated reactionware [2][3][4][5][6][7], DNA adhesives [8], inserts for cuvettes [9] or X-ray absorption spectroscopy [10] that enable spectroelectrochemistry to be performed, surgical models and synthetic organs [11] and microfluidic pumps [12]. However, whilst there are a significant number of recent research success stories demonstrating the potential applications of 3D-printers, a number of key challenges remain. In particular the additive manufacturing process of FDM printing has a tendency to create small gaps between successive extruded layers, meaning 3D-prints are not always air or watertight. This is a particular challenge for FDM 3D-printing in milli or microfluidic applications where the pressure in the device is increased. Strategies for solving this leakage problem differ, one approach is to construct devices with increased wall thicknesses, typically 4 mm [3], although this does impose a lower limit on the size of device that can be constructed. Alternatively, recent work [13] has shown that many of these printing imperfections in ABS prints can be removed with acetone and that 3D-prints treated in this way, post production, have potential uses in fluid handling on a variety of scales.Here we report our recent success using FDM 3D-printing to develop an inexpensive water heated UV visible cuvette made from ABS or PLA, which fits into a standard UV visible spectrometer.UV visible spectroscopy was performed on a dual beam Shimadzu Corporation UV-2410PC spectrometer equipped with a single monochromator. BRAND® disposable polystyrene cuvettes (Sigma-Aldrich UK) were used for control studies. Cobalt nitrate, sodium dodecyl sulphate (SDS) and dsDNA from salmon sperm were purchased from Sigma-Aldrich UK. Cobalt chloride was purchased from ACROS organics UK and acetone, propan-2-ol and methylene blue were purchased from Fisher Scientific UK. A REFCO (-1 to 3 Bar; class 1.6) p...

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Section: Determination Of the Thermochromic Shift Of Mixtures Of Coclmentioning

confidence: 99%

mentioning

confidence: 99%

A low volume 3D-printed temperature-controllable cuvette for UV visible spectroscopy

Pisaruka

Dymond

2016

Analytical Biochemistry

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“…Three-dimensional (3D) printing is a manufacturing method in which objects are made by fusing or depositing materials such as plastic, metal, ceramics, powders, liquids, or even living cells in layers to produce a 3D object [11,12]. This process is also referred to as additive manufacturing (AM), rapid prototyping (RP), or solid freeform technology (SFF) [13].…”

Section: Printing and Customized Implantsmentioning

confidence: 99%

“…Medical applications for 3D printing are expanding rapidly day after day and start to be included in different branches of medicine [11].…”

Section: Printing and Customized Implantsmentioning

confidence: 99%

The Cutting Edge in Oral and Maxillofacial Surgery

Hegab¹

2015

J Oral Hyg Health

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The vision for the future with advanced technology and science for easy and better treatments outcome motivating the clinicians to look-forward to practical the cutting edge tactics in the Oral and Maxillofacial Surgery. The results will be providing the patients with first-class medical services with reduction of the treatment morbidity. Greater progress has been made in the field of the Oral and Maxillofacial Surgery. In the last decades, the researchers were concentered on the improvement of the preoperative planning as it plays a vital role in the success rate of the surgical procedures. Now, as a result of the advanced computer technology, the researches extend beyond the scope of planning and moving toward the surgical procedures itself.Evolution over the last decades focused toward improvement of the preoperative planning, minimally invasive approaches, and minimizing the operation time. All aiming to decrease surgical complications and less post-operative pain and rapid return to normal life-style activities. As a result; remarkable recent advances in surgical and computer technology are evolving every day. Innovations in Oral and Maxillofacial Surgery have allowed the professions to progress at a very fast rate and looked-for for more every day. The increased accuracy and speed of treatment, along with reduced discomfort, and decreased the complications will be the actual advantages to our patients.The aim of the current review is to give an insight about the cutting edge in the field of oral and maxillofacial surgery to provide a more detailed physical manifestation of your mental picture and a new dimension of insight into the clinical situations you encounter every day.

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“…These fabrication processes, however, possess limitations for organlike structure productions. Although recent progress in tissue engineering has focused on using 3D printer schemes, there are still limitations such as the shortage of appropriate printing materials and technical challenges related to the sensitivity of living cells (10)(11)(12).…”

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confidence: 99%

Hydrogel-laden paper scaffold system for origami-based tissue engineering

Kim

Lee

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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In this study, we present a method for assembling biofunctionalized paper into a multiform structured scaffold system for reliable tissue regeneration using an origami-based approach. The surface of a paper was conformally modified with a poly(styrene-comaleic anhydride) layer via initiated chemical vapor deposition followed by the immobilization of poly-L-lysine (PLL) and deposition of Ca 2+ . This procedure ensures the formation of alginate hydrogel on the paper due to Ca 2+ diffusion. Furthermore, strong adhesion of the alginate hydrogel on the paper onto the paper substrate was achieved due to an electrostatic interaction between the alginate and PLL. The developed scaffold system was versatile and allowed area-selective cell seeding. Also, the hydrogel-laden paper could be folded freely into 3D tissue-like structures using a simple origamibased method. The cylindrically constructed paper scaffold system with chondrocytes was applied into a three-ring defect trachea in rabbits. The transplanted engineered tissues replaced the native trachea without stenosis after 4 wks. As for the custom-built scaffold system, the hydrogel-laden paper system will provide a robust and facile method for the formation of tissues mimicking native tissue constructs.paper scaffolds | origami | tissue engineering | initiated chemical vapor deposition | hydrogel T he living organ changes its shape from a sheet-like arrangement with primitive cells to mature three-dimensional (3D) structures through morphogenetic processes (1-3). To date, a wide range of biomaterials have been used for the total or partial replacement of damaged organs and/or tissue structures (4-7). As the functions of the living organ are realized by periodic changes in the spatial arrangement of tissue elements, multiform scaffold systems mimicking the native tissue are desired. Moldcasting and electrospinning, among various other methods, have been introduced to fabricate diverse scaffolds (8, 9). These fabrication processes, however, possess limitations for organlike structure productions. Although recent progress in tissue engineering has focused on using 3D printer schemes, there are still limitations such as the shortage of appropriate printing materials and technical challenges related to the sensitivity of living cells (10-12).Paper-based scaffolds have been used previously for cell culture platforms (13), high-throughput biochemical assay platforms (14), and a point-of-care diagnostic system (15). As a nature-originated substrate, paper has attracted enormous research interest for applications in tissue engineering (16). Cellulose-based paper may serve as a promising material for tissue engineering as it contains macroporous structures that allow nutrient transport and oxygenation (13). In this regard, paper origami is a simple alternative approach for fabricating a multiform scaffold. Based on computeraided design (CAD) planar figures, a variety of shaped scaffolds could be designed using biofunctionalized paper.In this report, a vapor-phase method, init...

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Innovations in 3D printing: a 3D overview from optics to organs

Cited by 618 publications

References 11 publications

A low volume 3D-printed temperature-controllable cuvette for UV visible spectroscopy

A low volume 3D-printed temperature-controllable cuvette for UV visible spectroscopy

The Cutting Edge in Oral and Maxillofacial Surgery

Hydrogel-laden paper scaffold system for origami-based tissue engineering

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