Innovations in assisted reproductive technologies: impact on contemporary donor egg practice and future advances

Christianson, Mindy S.; Bellver, José

doi:10.1016/j.fertnstert.2018.09.020

Cited by 14 publications

(5 citation statements)

References 107 publications

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“…It is a technology similar to sperm donation, except that the donor woman undergoes hormonal treatment to hyper stimulate ovulation (Christianson and Bellver, 2018). Then the surgically taken eggs are donated to the infertile couple to be combined with the sperm, either by intrafallopian gamete transfer (GIFT) or by in vitro fertilization (IVF) (Kolibianakis et al, 2010(Kolibianakis et al, , pp.…”

Section: Donation Of Eggsmentioning

confidence: 99%

Moral considerations on infertility and artificial reproductive technics

Negrut

Pop²

2022

JEET

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Purpose The purpose of this paper is to offer a Christian perspective on the ethical issues related to natural procreation and artificial reproduction methods. Design/methodology/approach This paper uses descriptive and comparative methodology between the ethical aspects specific to natural procreation and artificial reproduction. Findings Religious beliefs play a significant role in shaping the moral perspective when an infertile couple is confronted with the choice between natural procreation and artificial reproduction. Originality/value This paper survey a broad bibliography and offers a critical evaluation of the moral aspects specific to different methods of reproductive technologies compared to the natural procreation approach.

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Section: Donation Of Eggsmentioning

confidence: 99%

Moral considerations on infertility and artificial reproductive technics

Negrut

Pop²

2022

JEET

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“…І хоча доказова база ефективності застосування мелатоніну тільки формується, позитивні результати захисту яйцеклітин від вільних радикалів для збереження їх якості відомі [27,28,29]. Аналіз частоти настання вагітності у пацієнток, які отримували мелатонін, також засвідчив, що вона була вищою.…”

Section: рис 3 частота настання вагітності на перенесення ембріонів (...unclassified

Embryological Indicators and Incidence of Pregnancy in Women With Infertility Undergoing Assisted Reproductive Tecnology Programs With the Use of Melatonin

Yuzko¹,

Yuzko²,

Yuzko³

et al. 2022

Neonatol. hìr. perinat. med.

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The technology of intracytoplasmic sperm injection into the egg cell (ICSI) has taken the mail place among assisted reproductive technologies (ART) in the treatment of infertility. Improving the effectivenessof ART remains a complex medical problem. To a large extent, the success of ICSI depends on the quality of theoocytes, which, in its turn, depends on the number of follicles, which is determined by the ovulatory = ovarianreserve (OV) and effective preparation of patients for ART. The markers of OV are well known, and attention has been drawn to melatonin as a possible prognostic factor for the effectiveness of ART and OV in the last ten years. The indicators of melatonin content in the follicular fluid of stimulated ovaries have not been studied. At the same time, the assessment of embryological indicators of fertilization when using the medication melatonin for the preparation of patients and the effectiveness of ART programs in general can be useful for the furtherdevelopment of treatment algorithms for patients with infertility. The objective of the study. Evaluation of embryological indicators, the effectiveness of ICSI programs andthe incidence of pregnancy in women with infertility during their preparation with melatonin. Materials and methods. 67 women with various infertility factors participated in the prospective study.All patients were prepared for controlled ovarian stimulation (COS), and subsequently for follicular puncture, oocyte retrieval and fertilization by ICSI. All obtained blastocysts were cryopreserved, stored in liquid Nitrogen and thawed when embryo transfer was necessary. Embryological indicators, the number of transfers and the effectiveness of pregnancy incidence were evaluated. According to the purpose of the task, the patients were divided into two groups by the method of even-odd numbers: group 1 – 29 patients with infertility, who received the preparation "Vita-melatonin" 3 mg orally before bedtime, during one month before the follicles puncture,group 2 – 38 patients with infertility, who did not receive this medicine. Statistical processing of the obtainedresults was carried out using the licensed programs "Microsoft Excel" and "Statistica".The research design and all the methods we used in this prospective study were reviewed and approved by the bioethics commission of the higher education institution "Bukovinian State Medical University" (protocol No. 7 dated 04/21/2022). SRW "Preservation and restoration of reproductive health of women and girls with obstetric andgynecological pathology" (state registration number 0121U110020. Implementation period – 01.2021-12.2025). Results of the research. The incidence of pregnancy after thawing of blastocysts and embryo transfers ingeneral in women who received melatonin was significantly (p ˂ 0.05) higher compared to women who didnot receive melatonin, respectively, 86.2 ± 6.41% and 76.3 ± 6.95%. For all performed embryo transfers, theincidence of pregnancy was 56.8 ± 8.24% and 52.8 ± 7.62% (p > 0.05), respectively, for the first embryo transfer 58.1 ± 8 .85% and 55.3 ± 8.15% (р > 0.05), for the second - 43.5 ± 16.53% and 33.3 ± 21.14% (р > 0.05), for the third – 100.0 ± 7.00% and 80.0 ± 17.95% (р > 0.05).When assessing embryological indicators, it was found that in women who received melatonin, the number of mature oocytes was 83.4 ± 6.94%, and in women who did not receive melatonin, 81.5 ± 6.36%, but there was no significant (p > 0.05) difference. Out of mature oocytes in the process of incubation after the ICSI technology,49.5 ± 9.54% and 47.2 ± 8.72 (р > 0.05) blastocysts were formed, respectively, and from them blastocysts of class I – 48.6 ± 9 .36% and 46.4 ± 8.17% (р > 0.05), class II – 36.8 ± 8.94% and 44.4 ± 8.13% (р > 0.05), class III – 14.6 ± 6.67% and 9.3 ± 4.78% (р > 0.05).Conclusion. The use of melatonin in the preparation of women with infertility for the use of assisted reproductive technologies has shown its effectiveness in terms of pregnancy incidence.

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“…It is estimated that 85% of the embryos by assisted reproductive techniques do not implant after transfer. [ 6 7 8 ] Studies have shown that different methods have been used to manage recurrent implantation failures, but there is little consensus on the most effective ones. The common methods used include blastocyst transmission, pre-transplant genetic screening, hatching, co-culture system, sequential transmission, hysteroscopy, endometrial scratch, salpingectomy, additional ET, egg donation, and immunotherapy, but there is no proven evidence for these treatments.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the effect of intrauterine injection of platelet-rich plasma on the pregnancy rate of patients with a history of implantation failure in the in vitro fertilization cycle

Ershadi

Noori

Dashipoor

et al. 2022

Journal of Family Medicine and Primary Care

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Objectives: Implantation failure is a major problem in reproductive medicine, and despite the various methods described for treatment, there is little consensus on the most effective method. This study was conducted to investigate the effect of intrauterine injection of platelet-rich plasma (PRP) on the pregnancy rate of patients with a history of implantation failure in the in vitro fertilization (IVF) cycle. Study Design: In this study, women attending the infertility clinic of Ali ibn Abi Taleb Hospital, who had a history of implantation failure and were candidates for frozen embryo transfer (FET), were examined in Zahedan (Iran) in 2019. The patients were divided into two groups of PRP recipients and the control group. IVF was performed routinely, and in the PRP-receiving group, an intrauterine injection was given 48 h before embryo transfer (ET). The number of gestational sacs, the rate of implantation, the frequency of chemical and clinical pregnancies as well as the frequency of abortion were compared in the two groups. The collected data were analyzed by the SPSS software version 21 Results: Ninety patients with a history of implantation failure participated in the study, and finally, the information of 85 patients was studied. The frequency of chemical pregnancy was 40% in the experimental group, 27% in the control group, and regarding clinical pregnancy, 33% in the experimental group and 24% in the control group, but there was no significant difference between the two groups. The rate of implantation, the mean thickness of the endometrium, and the frequency of abortion did not differ significantly between the two groups Conclusion: In patients with endometrial thickness greater than 8 mm with a history of recurrent implantation failure, intrauterine injection of PRP had no effect on the fertility outcome.

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Innovations in assisted reproductive technologies: impact on contemporary donor egg practice and future advances

Cited by 14 publications

References 107 publications

Moral considerations on infertility and artificial reproductive technics

Moral considerations on infertility and artificial reproductive technics

Embryological Indicators and Incidence of Pregnancy in Women With Infertility Undergoing Assisted Reproductive Tecnology Programs With the Use of Melatonin

Evaluation of the effect of intrauterine injection of platelet-rich plasma on the pregnancy rate of patients with a history of implantation failure in the in vitro fertilization cycle

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