Innovations in Cardiovascular MR and PET-MR Imaging

Muñoz, Camila; Cruz, Gastão; Prieto, Claudia; Botnar, René M.

doi:10.1007/978-3-030-83167-7_14

Cited by 3 publications

(3 citation statements)

References 159 publications

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“…Additionally, PET‐MR imaging has shown promise for enhanced characterization of cardiovascular disease. Motion correction of PET data using MR has demonstrated to improve the PET images 43,44 . One of the approaches was proposed by Kolbitsch et al, 45 where PET data were corrected using single contrast MRI making cardiac PET results more reproducible.…”

Section: Discussionmentioning

confidence: 99%

“…Motion correction of PET data using MR has demonstrated to improve the PET images. 43,44 One of the approaches was proposed by Kolbitsch et al, 45 where PET data were corrected using single contrast MRI making cardiac PET results more reproducible. In our work, T 2 mapping adds diagnostic value to the simultaneous PET-MR acquisition, which is especially useful in patients with inflammatory diseases like cardiac sarcoidosis.…”

Section: F I G U R Ementioning

confidence: 99%

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Non‐rigid motion‐compensated 3D whole‐heart T₂ mapping in a hybrid 3T PET‐MR system

Schneider,

Munoz,

Hua

et al. 2024

Magnetic Resonance in Med

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PurposeSimultaneous PET‐MRI improves inflammatory cardiac disease diagnosis. However, challenges persist in respiratory motion and mis‐registration between free‐breathing 3D PET and 2D breath‐held MR images. We propose a free‐breathing non‐rigid motion‐compensated 3D T2‐mapping sequence enabling whole‐heart myocardial tissue characterization in a hybrid 3T PET‐MR system and provides non‐rigid respiratory motion fields to correct also simultaneously acquired PET data.MethodsFree‐breathing 3D whole‐heart T2‐mapping was implemented on a hybrid 3T PET‐MRI system. Three datasets were acquired with different T2‐preparation modules (0, 28, 55 ms) using 3‐fold undersampled variable‐density Cartesian trajectory. Respiratory motion was estimated via virtual 3D image navigators, enabling multi‐contrast non‐rigid motion‐corrected MR reconstruction. T2‐maps were computed using dictionary‐matching. Approach was tested in phantom, 8 healthy subjects, 14 MR only and 2 PET‐MR patients with suspected cardiac disease and compared with spin echo reference (phantom) and clinical 2D T2‐mapping (in‐vivo).ResultsPhantom results show a high correlation (R2 = 0.996) between proposed approach and gold standard 2D T2 mapping. In‐vivo 3D T2‐mapping average values in healthy subjects (39.0 ± 1.4 ms) and patients (healthy tissue) (39.1 ± 1.4 ms) agree with conventional 2D T2‐mapping (healthy = 38.6 ± 1.2 ms, patients = 40.3 ± 1.7 ms). Bland–Altman analysis reveals bias of 1.8 ms and 95% limits of agreement (LOA) of −2.4‐6 ms for healthy subjects, and bias of 1.3 ms and 95% LOA of −1.9 to 4.6 ms for patients.ConclusionValidated efficient 3D whole‐heart T2‐mapping at hybrid 3T PET‐MRI provides myocardial inflammation characterization and non‐rigid respiratory motion fields for simultaneous PET data correction. Comparable T2 values were achieved with both 3D and 2D methods. Improved image quality was observed in the PET images after MR‐based motion correction.

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Section: Discussionmentioning

confidence: 99%

Section: F I G U R Ementioning

confidence: 99%

Non‐rigid motion‐compensated 3D whole‐heart T₂ mapping in a hybrid 3T PET‐MR system

Schneider,

Munoz,

Hua

et al. 2024

Magnetic Resonance in Med

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“…By acquiring MR images that can provide respiratory and cardiac motion information, the simultaneously acquired PET data can be corrected for motion, resulting in improved delineation and quantification for cardiac PET images. A review of these techniques can be found in (51). While most of these techniques have focused on myocardial viability imaging with 18 F-FDG PET, the study by Robson et al (52) studied the potential of MR-based cardiac and respiratory motion correction in patients with CS, demonstrating that this approach resulted in improved visual appearance of the 18 F-FDG uptake pattern in areas of the heart most affected by motion, and in increased contrast of the detected lesions.…”

Section: Opportunities and Challengesmentioning

confidence: 99%

Recent advances in PET-MRI for cardiac sarcoidosis

et al. 2022

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The diagnosis of cardiac sarcoidosis (CS) remains challenging. While only a small fraction of patients with systemic sarcoidosis present with clinically symptomatic CS, cardiac involvement has been associated with adverse outcomes, such as ventricular arrhythmia, heart block, heart failure and sudden cardiac death. Despite the clinical relevance of having an early and accurate diagnosis of CS, there is no gold-standard technique available for the assessment of CS. Non-invasive PET and MR imaging have shown promise in the detection of different histopathological features of CS. More recently, the introduction of hybrid PET-MR scanners has enabled the acquisition of these hallmarks in a single scan, demonstrating higher sensitivity and specificity for CS detection and risk stratification than with either imaging modality alone. This article describes recent developments in hybrid PET-MR imaging for improving the diagnosis of CS and discusses areas of future development that could make cardiac PET-MRI the preferred diagnostic tool for the comprehensive assessment of CS.

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Imaging of Cardiac Fibrosis: How Far Have We Moved From Extracellular to Cellular?

Telli,

Hosseini,

Settelmeier

et al. 2024

Seminars in Nuclear Medicine

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Innovations in Cardiovascular MR and PET-MR Imaging

Cited by 3 publications

References 159 publications

Non‐rigid motion‐compensated 3D whole‐heart T₂ mapping in a hybrid 3T PET‐MR system

Non‐rigid motion‐compensated 3D whole‐heart T₂ mapping in a hybrid 3T PET‐MR system

Recent advances in PET-MRI for cardiac sarcoidosis

Imaging of Cardiac Fibrosis: How Far Have We Moved From Extracellular to Cellular?

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Innovations in Cardiovascular MR and PET-MR Imaging

Cited by 3 publications

References 159 publications

Non‐rigid motion‐compensated 3D whole‐heart T2 mapping in a hybrid 3T PET‐MR system

Non‐rigid motion‐compensated 3D whole‐heart T2 mapping in a hybrid 3T PET‐MR system

Recent advances in PET-MRI for cardiac sarcoidosis

Imaging of Cardiac Fibrosis: How Far Have We Moved From Extracellular to Cellular?

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Product

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Non‐rigid motion‐compensated 3D whole‐heart T₂ mapping in a hybrid 3T PET‐MR system

Non‐rigid motion‐compensated 3D whole‐heart T₂ mapping in a hybrid 3T PET‐MR system