Innovations in Medicine and Medical Research Vol. 3

Usman, Said; Alamsyah, Teuku; Kasumagić-Halilovic, Emina; Ovčina-Kurtović, Nermina; Marticorena, Joaquín; Romano, Vito; Gómez‐Ulla, Francisco; Yasaki, Shunji; Eugene, Alagbu Chukwubuikem; Adline, Alagbu Chinwe; Blessing, Chike Ijezie Ifeoma; Okey, Agwubike Elias; Ekejiuba, Paullete; Blessing, Chike-Ijezie Ifeoma; Edith, Akude Azuka; Udegbe, Okechukwu Charles; Yadav, Diksha; Farský, Štefan; Strišková, Andrea; Borčin, Marián; Bubnovskaya, Larissa; Kovelskaya, Antonina; Gumenyuk, Lilya; Ganusevich, Irina; Мамонтова, Л. С.; Mikhailenko, V. A.; Osinsky, Dmitry; Merentsev, Sergej; Osinsky, Sergej; Biswas, Saptarshi; Gogna, Shekhar; Patel, P; Georgosopoulou, Maria Lyra; Limouris, Georgios S.; Ganvir, Neha N.

doi:10.9734/bpi/immr/v3

2020

DOI: 10.9734/bpi/immr/v3

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Innovations in Medicine and Medical Research Vol. 3

Said Usman¹,

Teuku Alamsyah²,

Emina Kasumagić-Halilovic³

et al.

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Cancer-Associated Adipocytes and Prognostic Value of Preoperative Neutrophil-Lymphocyte Ratio in Gastric Cancer

Bubnovskaya¹,

Ganusevich²,

Merentsev³

et al. 2023

Exp. oncol.

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Background: The neutrophil-to-lymphocyte ratio (NLR) turned out to be a routinely available marker capable to reflect the systemic inflammatory response created by a tumor. Gastric cancer (GC) grows in the anatomical vicinity of adipose tissue, which is also associated with low-grade inflammation. Aim: To investigate the usefulness of the combined use of preoperative NLR and density of intratumoral cancer-associated adipocytes (CAAs) for predicting the disease outcome in GC patients. Materials and Methods: A total of 151 patients with GC were eligible for retrospective analysis between 2009 and 2015.NLR preoperative values were calculated. Perilipin expression in tumor tissue was examined immunohistochemically. Results: Low preoperative NLR is the most reliable prognostic factor for the favorable outcome for patients with low density of intratumoral CAAs. Patients with a high density of CCAs are at high risk of lethal outcomes independently of the value of preoperative NLR. Conclusion: The results have clearly shown an association between preoperative NLR and the density of CAAs in the primary tumor of GC patients. The prognostic value of NLR is essentially modified by means of the individual density of intratumoral CAAs in GC patients.The elevated NLR could be of significant predictive potential for a negative prognosis for patients with tumors characterized by the high density of CAAs independently of BMI.

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Cancer-Associated Adipocytes and Prognostic Value of Preoperative Neutrophil-Lymphocyte Ratio in Gastric Cancer

Bubnovskaya¹,

Ganusevich²,

Merentsev³

et al. 2023

Exp. oncol.

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show abstract

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Innovations in Medicine and Medical Research Vol. 3

Cited by 1 publication

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Cancer-Associated Adipocytes and Prognostic Value of Preoperative Neutrophil-Lymphocyte Ratio in Gastric Cancer

Cancer-Associated Adipocytes and Prognostic Value of Preoperative Neutrophil-Lymphocyte Ratio in Gastric Cancer

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