Innovations in Oligonucleotide Drug Delivery

Lysik, Melanie A.; Wu‐Pong, Susanna

doi:10.1002/jps.10399

Cited by 83 publications

(49 citation statements)

References 118 publications

(132 reference statements)

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“…Nanosystems like dendrimers, liposomes, niosomes, metal based NPs, micelles, nanoemulsions, quantum dots and polymer NPs have been developed (Table 2). They are expected to overcome the limitations such as poor solubility and stability at physiological pH, inadequate biodistribution, low bioavailability, which are observed when anticancer drugs are administered in a conventional way [4,9,10,32,36,[55][56][57][58]. Physico-chemical properties such as composition, shape, roughness, hydrophobicity or hydrophilicity, hydrodynamic diameter and surface charge influence the stability of DDS nanosystems [12,59] and their drug delivery applications [8,60].…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

Supramolecular nanoscale assemblies for cancer diagnosis and therapy

Coelho

Pereira

Juzeniene

et al. 2015

Journal of Controlled Release

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Nanocarriers based on polymers, metals and lipids have been extensively developed for cancer therapy and diagnosis due to their ability to enhance drug accumulation in cancer cells and decrease undesired drug toxicity in healthy tissues. Overcoming multidrug resistance by designing proper drug nanocarriers will improve outcome of existing oncologic treatments such as chemotherapy or radiotherapy. In this article the relation between physicochemical properties and capacity of a nanosystem to deliver therapeutic agents into pathological sites is discussed. Most promising examples of drug delivery systems are reviewed, and, in particular, the design of a carbohydrate based matrix with entrapped gold nanoparticles is highlighted.

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Section: Drug Delivery Systemsmentioning

confidence: 99%

Supramolecular nanoscale assemblies for cancer diagnosis and therapy

Coelho

Pereira

Juzeniene

et al. 2015

Journal of Controlled Release

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“…So far, a number of delivery vehicles have been investigated to improve the internalization efficiency of nucleic acids, including the use of carriers such as liposomes, peptides, and viral vectors. These techniques have been extensively reviewed elsewhere [1,[34][35][36][37][38][39][40][41][42][43]. In this section, nucleic acid delivery using carbohydrates as mediators will be discussed.…”

Section: Nucleic Acid Delivery Techniquesmentioning

confidence: 99%

Glycotargeting to improve cellular delivery efficiency of nucleic acids

Yan

Tram

2007

Glycoconj J

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Nucleic acids bearing glycans of various structures have been under vigorous investigation in the past decade. The carbohydrate moieties of such complexes can serve as recognition sites for carbohydrate-binding proteins-lectins-and initiate receptor-mediated endocytosis. Therefore, carbohydrates can enhance cell targeting and internalization of nucleic acids that are associated with them and thus improve the bioavailability of nucleic acids as therapeutic agents. This review summarizes nucleic acid glycosylation in nature and approaches for the preparation of both non-covalently associated and covalently-linked carbohydrate-nucleic acid complexes.

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“…For a more detailed discussion of this important fi eld, the interested reader is referred to recent reviews. 162,143 Rather surprisingly, it was found possible to form a lipoplex from DNA and a zwitterionic multilamellar phase at high lipid/DNA weight ratios. 163 The impetus for these studies was the lower cytotoxicity of neutral (and also negatively charged) liposomes.…”

Section: Lipoplex Structurementioning

confidence: 99%