Innovations in Pain Management: Morphine Combined with Omega-3 Fatty Acids

Laino, Carlos Horacio

doi:10.2174/221028901708010052

Cited by 3 publications

(3 citation statements)

References 101 publications

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“…Furthermore, it has been shown that morphine-induced behavioral and cellular adaptations are markedly prevented by O3 treatment (Hakimian et al, 2017). Consistently, some studies have suggested the use of combined morphine-O3 therapy for pain management (Laino, 2017). On the other hand, there are evidence indicating that O3 supplementation prevents and sometimes reverses ethanol-induced complications in multiple systems.…”

mentioning

confidence: 88%

A history of ethanol intake accelerates the development of morphine analgesic tolerance: A protective potential for omega-3 fatty acids.

Ahmadi-Soleimani¹,

Azizi²,

Beheshti³

et al. 2023

Behavioral Neuroscience

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Adolescence is a critical life period during which significant neurodevelopmental changes occur within the central nervous system. Consistently, substance abuse in this stage has been found to induce persistent changes in brain responsiveness to future drug challenges. Nowadays, heavy episodic alcohol consumption during adolescence, also known as binge-drinking behavior, is a growing concern in modern societies. On the other hand, alcohol is well known to act as a gateway drug, that is, it promotes the individual's craving for consumption of other drugs of abuse. With this in mind, we aimed to assess whether adolescent ethanol exposure could alter the development of tolerance and dependence to morphine, as an available common opioid drug. Tail flick test was used to measure thermal nociceptive changes in adult male Wistar rats undergone ethanol/vehicle exposure during adolescence. Furthermore, morphine withdrawal syndrome was induced by naloxone injection, and behavioral signs were recorded for 20 min. It was found that adolescent ethanol intake facilitates morphine analgesic tolerance and decreases baseline latency; however, the severity of dependence is not significantly altered. Moreover, we found that 15 days of treatment with omega-3 fatty acids (O3) prevents the mentioned ethanol-induced changes suggesting a therapeutic potential for this compound. O3 supplementation, as an inexpensive and noninvasive method, may assist the clinicians to reverse the adverse effect of alcohol binge drinking on adolescents' brains and to reduce the vulnerability to drug exposure in adulthood.

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confidence: 88%

A history of ethanol intake accelerates the development of morphine analgesic tolerance: A protective potential for omega-3 fatty acids.

Ahmadi-Soleimani¹,

Azizi²,

Beheshti³

et al. 2023

Behavioral Neuroscience

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“…Omega 3 especially EPA has a long-chain structure equation with arachidonic acid (AA), thus it can be a competitor to replace arachidonic acid in the metabolic processes of cyclooxygenase (COX) and lipoxygenase (Kobayashi et al, 2006). This theory is strengthened by another study by Laino (2017), suggested that EPA can inhibit the COX mechanism, therefore, prostaglandins are not formed. Blockage of the COX enzyme would inhibit the conversion of AA to the proinflammatory PGs that mediate fever (Maroon and Bost, 2006).…”

Section: Antipyretic Effectmentioning

confidence: 99%

In-vivo Antipyretic Effect of Eel (Anguilla bicolor bicolor) Oil on Yeast-induced Fever on Mice

et al. 2019

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Fish oil has been studied for medicinal purposes, including its antipyretic properties. Eel (Anguilla bicolor bicolor) oil, which contains vitamins and fatty acids, including Omega-3 (EPA and DHA), is also expected to have the antipyretic effect. This research aimed to examine the antipyretic activity of eel oil on white mice (Mus musculus L.). An in-vivo study was done on thirty Swiss-Webster strain males mice that previously got 20% yeast-induced fever. Six treatments were applied including normal group (untreated), a negative control group (yeast-treated), a positive control group treated with acetaminophen (1.764 mg/20 g body weight), and three groups treated with eel oil (0.048, 0.096 and 0.192 g/20 g body weight, respectively). The data was analyzed statistically using one way ANOVA then was continued with LSD post hoc test. The results showed that eel oil has significantly reduced yeast-induced hyperthermia on mice five hours after application at doses 0.096 and 0.192 g/20 g body weight. Our finding suggests that eel oil possess antipyretic properties when was applied in certain doses, and this effect is presumably attributed to its high content of fatty acid, including EPA and DHA.

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“…and through modulation of central µ‐opioid receptors in diabetic neuropathy . In addition, different types of ω‐3, such as EPA plus DHA, ALA and DHA, have an analgesic effect …”

Section: Introductionmentioning

confidence: 99%

Beneficial effects of fish oil enriched in omega-3 fatty acids on the development and maintenance of neuropathic pain

Unda

Villegas

Toledo

et al. 2020

Journal of Pharmacy and Pharmacology

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Objective The aim of this work was to assess the preventive effect of an eicosapentaenoic acid/docosahexaenoic acid-concentrate fish oil on neuropathic pain development and regenerative features of sciatic nerve in rats. Methods In the present study, rats with chronic constriction injury (CCI) of the sciatic nerve and sham-operated ones received fish oil enriched in omega-3 fatty acids (0.36 or 0.72 g/kg per day, oral) or saline solution for 21 days, with thermal hyperalgesia and mechanical allodynia being assessed before and 3, 7, 14 and 21 days after injury. Key findings Fish oil enriched in omega-3 fatty acids (0.72 g/kg) reversed thermal hyperalgesia and significantly reduced mechanical allodynia. In addition, x-3 treatment (0.72 g/kg) promoted the recovery of the Sciatic Functional Index as well as restored axonal density and morphology, without the formation of neuroma in the injured sciatic nerves after 21 days. Conclusion We conclude that the fish oil enriched in omega-3 fatty acids administration relieves thermal hyperalgesia and mechanical allodynia effectively and also enhances the recovery process in rats with CCI of the sciatic nerve. These findings might contribute to new therapeutic approaches including omega-3 fatty acids in neuropathic pain treatment.

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Innovations in Pain Management: Morphine Combined with Omega-3 Fatty Acids

Cited by 3 publications

References 101 publications

A history of ethanol intake accelerates the development of morphine analgesic tolerance: A protective potential for omega-3 fatty acids.

A history of ethanol intake accelerates the development of morphine analgesic tolerance: A protective potential for omega-3 fatty acids.

In-vivo Antipyretic Effect of Eel (Anguilla bicolor bicolor) Oil on Yeast-induced Fever on Mice

Beneficial effects of fish oil enriched in omega-3 fatty acids on the development and maintenance of neuropathic pain

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