Innovations in the Delivery of Exposure and Response Prevention for Obsessive-Compulsive Disorder

Patel, Sapana R.; Comer, Jonathan S.; Simpson, Helen Blair

doi:10.1007/7854_2020_202

Cited by 4 publications

(2 citation statements)

References 148 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By contrast, recent research in our laboratory found that chronic THC administration delayed SID acquisition, and acute THC administration reduced SID only in rats that had previously experienced a chronic treatment with the same drug, suggesting a sensitization-like effect (Fuentes-Verdugo et al 2022). Clinical trials have shown that cannabis users with OCD reported that cannabinoids mitigated their symptoms, including obsessions and compulsions (Müller-Vahl 2013;Schindler et al 2008;Szejko et al 2020;Patel et al 2021), and another recent study reported that nabilone, a synthetic cannabinoid with similar effects to THC, alleviated OCD severity in combination with exposure and response prevention therapy, nearly doubling the effect compared to exposure and response prevention alone (Kayser et al 2020). All this evidence points to ECS as a potential target for novel medications aiming OCD symptoms.…”

Section: Introductionmentioning

confidence: 80%

Repeated Δ-9-Tetrahydrocannabinol administration dose dependently increases stablished schedule-induced drinking

Fuentes-Verdugo,

Pellón,

Miguéns

2024

Psychopharmacology

View full text Add to dashboard Cite

Rationale Schedule-induced drinking (SID) reproduces an excessive and repetitive behavioural pattern that has led to propose this procedure as an animal model to study compulsive behaviours. Although it is known that cannabis can cause several adverse effects, in recent years there has been great interest in the medical application of cannabis derivatives for obsessive-compulsive related disorders. Objectives The present study investigated the effects of repeated THC administration on rates of previously acquired SID, as well as the possible alteration of its temporal distribution along inter-food intervals. Methods Male Wistar rats acquired SID under a 30 min fixed-time 30-sec food delivery schedule (from 30 to 43 sessions to reach a stable level). Thereafter, 5 or 10 mg/kg daily i.p. injections of THC or vehicle were repeatedly administered for 7 days to evaluate the effects on SID. Results Repeated THC administration at a dose of 5 mg/kg resulted in an increase on licking. Surprisingly, no effects on SID were observed with the 10 mg/kg dose. However, magazine entries were reduced with both THC doses. THC also modified the temporal distributions of licking and magazine entries during inter-food intervals. Conclusions The present results show that repeated THC administration may (i) increase induced licking at moderate doses, (ii) reduce magazine entries, and (iii) affect the temporal pattern of SID. These findings suggest that THC does not appear to be beneficial to reduce compulsive behaviour in this animal model, while another collateral effect of THC —such as a greater habitual-like behaviour— needs to be considered.

show abstract

Section: Introductionmentioning

confidence: 80%

Repeated Δ-9-Tetrahydrocannabinol administration dose dependently increases stablished schedule-induced drinking

Fuentes-Verdugo,

Pellón,

Miguéns

2024

Psychopharmacology

View full text Add to dashboard Cite

show abstract

“…If an imbalance between goal-directed and habitual control play a central role in OCS/OCD, where compulsive behaviors are thought to be controlled by habitual systems, then breaking these compulsive habitual behaviors and restoring goal-directed control is likely important for intervention efforts (Kalanthroff et al, 2018). The most used technique to treat OCD is Cognitive Behavior Therapy (CBT) which uses exposure and response techniques (see Patel et al, 2021). This technique involves teaching individuals to confront situations that result in obsessions and inhibit compulsive behaviors.…”

Section: Ocs/ocd and The Habit Hypothesismentioning

confidence: 99%

Associations between somatomotor-putamen resting state connectivity and obsessive-compulsive symptoms vary as a function of stress during early adolescence: Data from the ABCD study

Petrie,

Meeks,

Fisher

et al. 2023

Preprint

View full text Add to dashboard Cite

Obsessive-compulsive symptoms (OCS) are relatively common during adolescence despite the fact that most individuals do not meet the diagnostic criteria for obsessive-compulsive disorder (OCD). Nonetheless, OCS during adolescence are associated with various comorbid psychopathologies and behavioral problems. Heightened levels of environmental stress and greater functional connectivity between the somatomotor network and putamen are two factors previously associated with elevated OCS, particularly in OCD patients relative to healthy controls. However, the interaction of these two factors within the same sample of individuals has been understudied. In this study, we examined resting state functional connectivity between the somatomotor network and the putamen, environmental stress, and their interaction on OCS in adolescents from approximately 9 to 12 years of age. Participants were drawn from the ABCD study 4.0 release (n = 6,386). Multilevel modeling was used to account for nesting in the data and to assess longitudinal changes in OCS in this age range. Results indicate that somatomotor-putamen connectivity moderated the association between stress and OCS (β = 0.35, S.E. = 0.13, p = 0.006). Participants who reported more stress than their average and who had greater somatomotor-left putamen connectivity reported more OCS at that wave. We also found that participants who reported less stress than their average and who had greater somatomotor-left putamen connectivity reported less OCS at that wave. These data suggest that stress differentially affects the direction and magnitude of association between somatomotor-putamen connectivity and OCS in participants from age 9 to 12. Individual differences in the experience or perception of stress may contribute to more OCS in adolescents with greater somatomotor-putamen connectivity.

show abstract

Chronic ∆-9-tetrahydrocannabinol administration delays acquisition of schedule-induced drinking in rats and retains long-lasting effects

et al. 2021

View full text Add to dashboard Cite

Rationale Schedule-induced drinking (SID) is a behavioural phenomenon characterized by an excessive and repetitive drinking pattern with a distinctive temporal distribution that has been proposed as a robust and replicable animal model of compulsivity. Despite cannabis currently being the most widely consumed illicit drug, with growing interest in its clinical applications, little is known about the effects of ∆-9-tetrahydrocannabinol (THC) on SID. Objectives The effects of chronic and acute THC administration on SID acquisition, maintenance and extinction were studied, as were the effects of such administrations on the distinctive temporal distribution pattern of SID. Methods THC (5 mg/kg i.p.), or the corresponding vehicle, was administered to adult Wistar rats for 14 days in a row. Subsequently, THC effects on SID acquisition were tested during 21 sessions using a 1-h fixed-time 60-s food delivery schedule. Acute effects of THC were also evaluated after SID development. Finally, two extinction sessions were conducted to assess behavioural persistence. Results The results showed that previous chronic THC treatment delayed SID acquisition and altered the distinctive behavioural temporal distribution pattern during sessions. Moreover, acute THC administration after SID development decreased SID performance in animals chronically pre-treated with the drug. No great persistence effects were observed during extinction in animals pre-treated with THC. Conclusions These results suggest that chronic THC affects SID development, confirming that it can disrupt learning, possibly causing alterations in time estimation, and also leads to animals being sensitized when they are re-exposed to the drug after long periods without drug exposure.

show abstract

Innovations in the Delivery of Exposure and Response Prevention for Obsessive-Compulsive Disorder

Cited by 4 publications

References 148 publications

Repeated Δ-9-Tetrahydrocannabinol administration dose dependently increases stablished schedule-induced drinking

Repeated Δ-9-Tetrahydrocannabinol administration dose dependently increases stablished schedule-induced drinking

Associations between somatomotor-putamen resting state connectivity and obsessive-compulsive symptoms vary as a function of stress during early adolescence: Data from the ABCD study

Chronic ∆-9-tetrahydrocannabinol administration delays acquisition of schedule-induced drinking in rats and retains long-lasting effects

Contact Info

Product

Resources

About