Innovations to Topical Therapy of Rosacea

Abstract

The main pathogenetic aspects of rosacea, various classifications of dermatosis and the modern clinical classification are presented. The symptoms that differentiate rosacea from other dermatoses are described. Contradictory of modern scientific concepts of different researchers, approaches to etiology, pathogenesis and treatment has been noted. The social significance of rosacea, the importance and possibility of eliminating the symptoms of the disease at early stages, the achievement and prolongation of remission are shown. The main triggers for the manifestation of rosacea, which should be taken into account to achieve the maximum effect in the treatment of the disease, are indicated. The domestic and foreign clinical recommendations on the treatment of the disease are considered in view of the appearance of new external drugs. The results of several studies in the USA and Canada on the efficacy of 1% ivermectin cream and 0.5% brimonidine tartrate gel compared to placebo are shown. The first domestic positive experience of self-study with 1% ivermectin cream (Solantra®) and 0.5% brimonidine tartrate gel (Mirvazo Derm®) is presented. The high efficacy and very good tolerability of this drugs, as well as the absence of any side effects in patients with moderate to severe rosacea are shown.

Erythematotelangiectatic rosacea: The combination of 0.5% brimonidine tartrate gel and broadband pulse light therapy to reverse its effects

“…Rosacea is localized mainly in the facial skin and is associated with the occurrence of transient or persistent erythema, telangiectasiasis, papulopustular elements, and nodes 4 . In 2002, the members of National Rosacea Society (USA) have published a classification system which helps standardize the diagnosis of rosacea, recognizing the following four main subtypes depending on the primary and secondary characteristics: erythematotelangiectatic rosacea, papulopustular rosacea, phymatous rosacea, and ocular rosacea 5 …”

“…4 In 2002, the members of National Rosacea Society (USA) have published a classification system which helps standardize the diagnosis of rosacea, recognizing the following four main subtypes depending on the primary and secondary characteristics: erythematotelangiectatic rosacea, papulopustular rosacea, phymatous rosacea, and ocular rosacea. 5 The etiology of rosacea is not fully known, but in the literature there are suggestions of causality of this disease. First of all, the development of diseases is associated with changes in the immune system.…”