Innovative and novel manufacturing methods of ceramics and metal-ceramic composites for biomedical applications

Ahlhelm, Matthias; Gunther, Paul; Scheithauer, Uwe; Schwarzer, Eric; Günther, Anne; Slawik, T.; Moritz, Tassilo; Michaelis, Alexander

doi:10.1016/j.jeurceramsoc.2015.12.020

Cited by 47 publications

(21 citation statements)

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“…The biggest use of AM is to create porous structures 265 often referred to as controlled architecture cellular materials 266 or metamaterials, 267 mostly for lightweight applications. However, AM is also being used in combination with other techniques like ice templating or foaming, 268 to produce porous materials. As described in this section, the creation of porous structures is one of the key and distinctive features that colloidal processing techniques bring to ceramics manufacture.…”

Section: Additive Manufacturingmentioning

confidence: 99%

Colloidal processing: enabling complex shaped ceramics with unique multiscale structures

et al. 2017

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Colloidal processing of fine ceramic powders enables the production of complex shaped ceramics with unique micro and macro structures which are not possible to produce via conventional dry processing routes. Because of this enhanced structural control and shaping capabilities, colloidal processing has been exploited to produce ceramic components with ever increasing complexity and functionalities. In this review, we revisit some of the research efforts on this topic to highlight its relevance and growing importance for the advanced manufacturing of functional ceramics. Selected examples of colloidal systems with increasing level of complexity are discussed to showcase the wide range of structures that can be generated through wet processing approaches. The historical development and background knowledge pertaining to colloids and surface interactions is first briefly reviewed. The major colloidal shape forming and additive manufacturing processes that utilize colloidal pastes and inks are then reviewed, highlighting the control of suspension rheology needed in these techniques. Next, methodologies that combine suspended particles with a pore‐forming phase are discussed as a means to produce porous ceramic materials. Further control over the interactions between anisotropic particles and their alignment in suspensions can be gained via externally applied fields (such as magnetic) to produce texturally aligned green bodies. This leads to bioinspired ceramics that can programmably morph into complex shaped objects upon sintering. Hierarchical porous structures with high mechanical efficiency are also shown as an example of the multiscale designs that can be generated through advanced colloidal processing. As drying of ceramic bodies is an inevitable consequence of wet colloidal processing, the current understanding of this critical processing step is reviewed. Finally, the gaps in knowledge in these fields are discussed to provide our perspective on where the field may support advances in ceramics in the future.

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Section: Additive Manufacturingmentioning

confidence: 99%

Colloidal processing: enabling complex shaped ceramics with unique multiscale structures

et al. 2017

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“…Another possible application is to modify carbon fibers with cenospheres in order to obtain ceramic-carbon materials for medical applications [46]. Other issues in which the use of cenospheres may add a new perspective involve metal-ceramic composites for lower weight orthopaedic implants, as well as additional enrichment with drugs that reduce the risk of inflammation and postoperative complications [47][48][49]. These and other possible applications will be discussed below.…”

Section: Possibilities For Cenosphere Applications In Biomedical Engimentioning

confidence: 99%

Cenospheres and their application advantages in biomedical engineering - a systematic review

Nakonieczny

Antonowicz

Paszenda

2020

Reviews on Advanced Materials Science

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Aluminum-silicate cenospheres are the most valuable residue present in fly ashes after combusting stone coal. Cenospheres are hollow bodies with desirable engineering properties, such as hardness, low bulk density and complete chemical inertness, thanks to which they can be used in biomedical engineering. The following review presents data on obtaining and processing the material, as well as potential biomedical applications.

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“…Ahlhelm et al combined LCM with Freeze Foaming methods and achieved successful full ceramic structures, combining dense and porous features in a single part of Zirconia suspension. [40] The development of Lithography-based technologies for the industrial production of biomedical parts has been pushed forward with the emergence of solutions such as the CeraFab 7500 (Lithoz, Gmbh, Wien, Austria) and the C3600-ultimate (3DCeram, Limoges, France), the latter based the Lithographic processing by four simultaneous laser sources.…”

Section: Additive Manufacturing For the Fabrication Of Implantsmentioning

confidence: 99%

Biological Responses of Ceramic Bone Spacers Produced by Green Processing of Additively Manufactured Thin Meshes

Minguella-Canela

Calero²,

Korkusuz

et al. 2020

Materials

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Bone spacers are exclusively used for replacing the tissue after trauma and/or diseases. Ceramic materials bring positive opportunities to enhance greater osteointegration and performance of implants, yet processing of porous geometries can be challenging. Additive Manufacturing (AM) opens opportunities to grade porosity levels in a part; however, its productivity may be low due to its batch processing approach. The paper studies the biological responses yielded by hydroxyapatite with β-TCP (tricalcium phosphate) ceramic porous bone spacers manufactured by robocasting 2-layer meshes that are rolled in green and sintered. The implants are assessed in vitro and in vivo for their compatibility. Human bone marrow mesenchymal stem cells attached, proliferated and differentiated on the bone spacers produced. Cells on the spacers presented alkaline phosphatase staining, confirming osteogenic differentiation. They also expressed bone-specific COL1A1, BGAP, BSP, and SPP1 genes. The fold change of these genes ranged between 8 to 16 folds compared to controls. When implanted into the subcutaneous tissue of rabbits, they triggered collagen fibre formation and mild fibroblastic proliferation. In conclusion, rolled AM-meshes bone spacers stimulated bone formation in vitro and were biocompatible in vivo. This technology may give the advantage to custom produce spacers at high production rates if industrially upscaled.

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Innovative and novel manufacturing methods of ceramics and metal-ceramic composites for biomedical applications

Cited by 47 publications

References 1 publication

Colloidal processing: enabling complex shaped ceramics with unique multiscale structures

Colloidal processing: enabling complex shaped ceramics with unique multiscale structures

Cenospheres and their application advantages in biomedical engineering - a systematic review

Biological Responses of Ceramic Bone Spacers Produced by Green Processing of Additively Manufactured Thin Meshes

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