2021
DOI: 10.1002/ddr.21886
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Innovative antimicrobial substances based on uracil S‐derivatives

Abstract: The problem of antimicrobial resistance is an important global public health challenge.We propose that a development of new antibiotic compounds around known natural substances is a solution to this problem. We investigate reengineer natural products into potent antibiotics. Uracil fragment is abundant in nature and significant to treat infectious diseases due to its affection to the replication of the bacterial chromosome.12 new uracil S-derivatives were obtained and tested for their in vitro antimicrobial pr… Show more

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“…Due to its affection to replicate the bacterial chromosome, uracil skeleton in many occasion showed significant efficacies to treat infectious diseases. 3 Figure 3 represents some uracil derivatives with potent anti-cancer efficacies. 4 5-Fluorouracil is a well-known drug, which is widely used for the treatment of solid tumors like colon or breast cancer.…”
Section: Introductionmentioning
confidence: 99%
“…Due to its affection to replicate the bacterial chromosome, uracil skeleton in many occasion showed significant efficacies to treat infectious diseases. 3 Figure 3 represents some uracil derivatives with potent anti-cancer efficacies. 4 5-Fluorouracil is a well-known drug, which is widely used for the treatment of solid tumors like colon or breast cancer.…”
Section: Introductionmentioning
confidence: 99%