2024
DOI: 10.1021/acs.analchem.4c03003
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Innovative Colorimetric NQO1 Detection Strategy via Substrate Competitive and Biomimetic Cascade Reactions with a Highly Active NADH Oxidase Mimic

Qi Fang,
Quanyi Liu,
Zhimin Song
et al.

Abstract: NAD(P)H: quinone oxidoreductase-1 (NQO1) plays critical roles in antioxidation and abnormally overexpresses in tumors. Developing a fast and sensitive method of monitoring NQO1 will greatly promote cancer diagnosis in clinical practice. This study introduces a transformative colorimetric detection strategy for NQO1, harnessing an innovative competitive substrate mechanism between NQO1 and a new NADH oxidase (NOX) mimic, cobalt−nitrogen-doped carbon nanozyme (CoNC). This method ingeniously exploits the differen… Show more

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