Innovative design of hollow polymeric microneedles for transdermal drug delivery

Lhernould, Marion Sausse; Delchambre, Alain

doi:10.1007/s00542-011-1355-2

Cited by 13 publications

(8 citation statements)

References 27 publications

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“…To date, there are contradictory opinions as to whether DMN will need to be used in combination with an applicator device. Several researchers and companies have reported the development of applicators for MN patches and the topic has been reviewed elsewhere 102–105. In the case of DMN, numerous studies have clearly demonstrated that DMN can be easily and reliably inserted into the skin by minimally trained personnel and patients, but further in-depth studies are required to ascertain if variability exists between users.…”

Section: Future Perspectivesmentioning

confidence: 99%

<p>Technology update: dissolvable microneedle patches for vaccine delivery</p>

Rodgers¹,

Cordeiro²,

Donnelly³

2019

MDER

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Despite vaccination representing one of the greatest advances of modern preventative medicine, there remain significant challenges in vaccine distribution, delivery and compliance. Dissolvable microarray patches or dissolving microneedles (DMN) have been proposed as an innovative vaccine delivery platform that could potentially revolutionize vaccine delivery and circumvent many of the challenges faced with current vaccine strategies. DMN, due to their ease of use, lack of elicitation of pain response, self-disabling nature and ease of transport and distribution, offer an attractive delivery option for vaccines. Additionally, as DMN inherently targets the uppermost skin layers, they facilitate improved vaccine efficacy, due to direct targeting of skin antigen-presenting cells. A plethora of publications have demonstrated the efficacy of DMN vaccination for a range of vaccines, with influenza receiving particular attention. However, before the viable adoption of DMN for vaccination purposes in a clinical setting, a number of fundamental questions must be addressed. Accordingly, this review begins by introducing some of the key barriers faced by current vaccination approaches and how DMN can overcome these challenges. We introduce some of the recent advances in the field of DMN technology, highlighting the potential impact DMN could have, particularly in countries of the developing world. We conclude by reflecting on some of the key questions that remain unanswered and which warrant further investigation before DMNs can be utilized in clinical settings.

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Section: Future Perspectivesmentioning

confidence: 99%

<p>Technology update: dissolvable microneedle patches for vaccine delivery</p>

Rodgers¹,

Cordeiro²,

Donnelly³

2019

MDER

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“…Our laboratory developed hollow polymer microneedles, which are 900 m microns tall structures in a 4 by 4 arrays, with a pitch to pitch distance of 2 mm. Detailed description of manufacturing and mechanical properties can be found in Sausse Lhernould and Delchambre (2011). Davis et al (2004) measured the insertion force for metal microneedles with a tip radius between 30 and 80 m and found results varying between 0.08 N and 3.04 N. Using needles with a tip diameter between 55 and 115 m, Park et al (2006) report forces between 0.8 N and 1.29 N. Recently developed ultrasharp microneedles (Roxhed et al, 2007), with 0.1 m tip radius, show the ability to insert into skin with a force less than 10 mN.…”

Section: Q2mentioning

confidence: 99%

Hollow polymer microneedles array resistance and insertion tests

Lhernould

Deleers

Delchambre

2015

International Journal of Pharmaceutics

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Microneedles are developed in order to become the transdermal administration method of the future. They however still face numerous challenges. This paper addresses the challenge to effectively insert the microneedle arrays into membranes. A recently proposed model membrane and test method for microneedles insertion, published in International Journal of Pharmaceutics, is used in this aim. A moulded 4 by 4 hollow polymer microneedle array developed at the Université Libre de Bruxelles is tested for insertion using this model. Results show that the array is extremely resistant to insertion, it can withstand very high forces and even multiple insertions without blunting. Different insertion tests were performed on a folded in eight Parafilm® film because it exhibits excellent similarity to porcine skin. The insertion force, the insertion speed and the holding time of the array against membranes must be optimised in order to get efficient reliable insertions at, at least, 500μm depth.

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“…Chen et al (2008) also outlined a fabrication process which used silicon oxide layers on silicon followed by a positive photoresist treatment for pattern transfer onto the silicon oxide layer via RIE and finally producing microneedle tips using an isotropic RIE process. Lhernould and Delchambre (2011) arrived at a design fabrication process of implementing laser ablation to create microchannels in polycarbonate material. Matteucci et al (2009) adapted the micro-fabrication process known in German as lithographie, galvanoformung, abformung (lithography, electroplating and molding) by Hruby (2001) which produced microneedles by double-exposure, deep X-ray lithography (Kim et al 2004) using microcrystalline silicon wafers surfaced with Cr/Au bilayer as a template.…”

Section: Preparation Of Biodegradable Microneedlesmentioning

confidence: 99%

“…Conventional hypodermic needle delivery causes pain and anxiety, and requires medical personnel for administration. In contrast, the biodegradable microneedle, a drugloaded vehicle moulded into an all-in-one drug formulated micro-structure constructed from either biopolymer or sugar excipients, can be used to deliver drug almost painlessly to humans (e.g., Donnelly et al 2010;Lhernould and Delchambre 2011;Olatunji and Das 2011;Gittard et al 2012). These microneedles are economical due to fairly cheap materials, reproducible and are generally safe if microneedle fragments break off after piercing the skin surface as compared to other microneedles made with glass or metal.…”

Section: Introductionmentioning

confidence: 99%

Potential of biodegradable microneedles as a transdermal delivery vehicle for lidocaine

Nayak

Das

2013

Biotechnol Lett

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There has been an increasing interest in applying biotechnology in formulating and characterising new and innovative drug delivery methods, e.g., drug-loaded biodegradable microneedles within the area of transdermal delivery technology. Recently, microneedles have been proposed for use in pain management, e.g., post-operative pain management through delivery of a local anaesthetic, namely, lidocaine. Lidocaine is a fairly common, marketed prescription-based local anaesthetic pharmaceutical, applied for relieving localised pain and lidocaine-loaded microneedles have been explored. The purpose of this review is to evaluate the properties of biodegradable polymers that may allow the preparation of microneedle systems, methods of preparing them and pharmacokinetic conditions in considering the potential use of lidocaine for delivery through the skin.

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Innovative design of hollow polymeric microneedles for transdermal drug delivery

Abstract: Hypodermic injections give the best results in terms of drug administration efficiency,

Cited by 13 publications

References 27 publications

<p>Technology update: dissolvable microneedle patches for vaccine delivery</p>

<p>Technology update: dissolvable microneedle patches for vaccine delivery</p>

Hollow polymer microneedles array resistance and insertion tests

Potential of biodegradable microneedles as a transdermal delivery vehicle for lidocaine

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