Innovative material containing the natural product curcumin, with enhanced antimicrobial properties for active packaging

Papadimitriou, A.; Ketikidis, I.; Stathopoulou, M-E.K.; Banti, Christina N.; Papachristodoulou, C.; Zoumpoulakis, L.; Agathopoulos, Simeon; Vagenas, G.V.; Hadjikakou, Sotiris K.

doi:10.1016/j.msec.2017.11.041

Cited by 41 publications

(47 citation statements)

References 16 publications

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“…Food packaging is associated with food quality, and NMR has the potential to play an important role in this area. Although there are several studies related to food packaging where NMR is used for the chemical characterization of packaging materials (Aytac et al, ; Papadimitriou et al., ; Razzaq et al., ; Šešlija et al., ; Wang et al., ), the real challenge from a food science perspective will be the application of NMR on studying the effects of different packaging materials on the composition, quality, safety, shelf life, and sensory perception of foods. Studies involve the monitoring of cheese degradation under various packaging conditions using 1 H‐NMR (Lamanna et al., ), the effect of gamma irradiation of food packaging materials (Pentimalli et al., ), determination of whether or not plastic food packaging materials comply with governmental agency regulations (Métois, Scholler, Bouquant, & Feigenbaum, ), and the identification of the additives in extracts of packaging plastics (Ehret‐Henry, Bouquant, Scholler, & Klinck, ).…”

Section: Fundamentals Of Nmr Spectroscopy‐relevance To Food Sciencementioning

confidence: 99%

Section: Nmr In Food Authenticationmentioning

confidence: 99%

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Nuclear Magnetic Resonance (NMR) Spectroscopy in Food Science: A Comprehensive Review

Hatzakis

2018

Comp Rev Food Sci Food Safe

281

126

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Nuclear magnetic resonance (NMR) spectroscopy is a robust method, which can rapidly analyze mixtures at the molecular level without requiring separation and/or purification steps, making it ideal for applications in food science. Despite its increasing popularity among food scientists, NMR is still an underutilized methodology in this area, mainly due to its high cost, relatively low sensitivity, and the lack of NMR expertise by many food scientists. The aim of this review is to help bridge the knowledge gap that may exist when attempting to apply NMR methodologies to the field of food science. We begin by covering the basic principles required to apply NMR to the study of foods and nutrients. A description of the discipline of chemometrics is provided, as the combination of NMR with multivariate statistical analysis is a powerful approach for addressing modern challenges in food science. Furthermore, a comprehensive overview of recent and key applications in the areas of compositional analysis, food authentication, quality control, and human nutrition is provided. In addition to standard NMR techniques, more sophisticated NMR applications are also presented, although limitations, gaps, and potentials are discussed. We hope this review will help scientists gain some of the knowledge required to apply the powerful methodology of NMR to the rich and diverse field of food science.

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Section: Fundamentals Of Nmr Spectroscopy‐relevance To Food Sciencementioning

confidence: 99%

Section: Nmr In Food Authenticationmentioning

confidence: 99%

Nuclear Magnetic Resonance (NMR) Spectroscopy in Food Science: A Comprehensive Review

Hatzakis

2018

Comp Rev Food Sci Food Safe

281

126

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“…The conjugation of metals with drugs (CoMeDs) is a new research area for the discovery of new synergistic therapeutic modalities. CoMeDs combines two different agents, such as silver(I) with penicillin to create new agents with new properties from the superimposition of those initially possessed by the constituents [6][7][8][9][10][11][12]. Although the term "conjugate" is more properly used for polymer-drugs or dendrimer-drug conjugates where nanoparticles are formed, recently, the term CoMeD has also been used to emphasize the synergistic effect of the coordination of a metal with drugs [13,14].…”

Section: Introductionmentioning

confidence: 99%

Conjugation of Penicillin-G with Silver(I) Ions Expands Its Antimicrobial Activity against Gram Negative Bacteria

et al. 2020

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Conjugation of penicillin G (PenH) with silver(I) ions forms a new CoMeD (conjugate of metal with a drug) with formula [Ag(pen)(CH3OH)]2 (PenAg). PenAg was characterized by a plethora of physical and spectroscopic techniques, which include in the solid state m.p.; elemental analysis; X-ray fluorescence (XRF) spectroscopy; scanning electron microscopy (SEM); energy-dispersive X-ray spectroscopy (EDX); FT-IR; and in solution: attenuated total reflection spectroscopy (FT-IR-ATR), UV–Vis, 1H NMR, and atomic absorption (AA). The structure of PenAg was determined by NMR spectroscopy. Silver(I) ions coordinate to the carboxylic group of PenH, while secondary intra-molecular interactions are developed through (i) the nitrogen atom of the amide group in MeOD-d4 or (ii) the sulfur atom in the thietane ring in deuterated dimethyl sulfoxide DMSO-d6. The antibacterial activities of PenAg and the sodium salt of penicillin (PenNa) (the formulation which is clinically used) against Gram positive (Staphylococcus epidermidis (S. epidermidis) and Staphylococcus aureus (S. aureus)) and Gram negative (Pseudomonas aeruginosa (P. aeuroginosa PAO1)) bacteria were evaluated by the means of minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and inhibition zone (IZ). PenAg inhibits the growth of the Gram negative bacterial strain P. aeuroginosa with a MIC value of 23.00 ± 2.29 μM, in contrast to PenNa, which shows no such activity (>2 mM). The corresponding antimicrobial activities of PenAg against the Gram positive bacteria S. epidermidis and S. aureus are even better than those of PenNa. Moreover, PenAg exhibits no in vivo toxicity against Artemia salina at concentration up to 300 μΜ. The wide therapeutic window and the low toxicity, make PenAg a possible candidate for the development of a new antibiotic.

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“…Zinc is an essential element for the microorganisms since it is involved in vital cellular reactions even at its low endogenous concentrations. The antimicrobial properties of Zn 2+ and its complexes have been known since long time now [10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

An Efficient Disinfectant, Composite Material {SLS@[Zn3(CitH)2]} as Ingredient for Development of Sterilized and Non Infectious Contact Lens

et al. 2019

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The [Zn3(CitH)2] (1) (CitH4= citric acid), was dispersed in sodium lauryl sulphate (SLS) to form the micelle of SLS@[Zn3(CitH)2] (2). This material 2 was incorporated in hydrogel made by hydroxyethyl-methacrylate (HEMA), an ingredient of contact lenses, toward the formation of pHEMA@(SLS@[Zn3(CitH)2]) (3). Samples of 1 and 2 were characterized by UV-Vis, 1H-NMR, FT-IR, FT-Raman, single crystal X-ray crystallography, X-ray fluorescence analysis, atomic absorption and TG/DTA/DSC. The antibacterial activity of 1–3 as well as of SLS against Gram-positive (Staphylococcus epidermidis (St. epidermidis) and Staphylococcus aureus (St. aureus)) and Gram-negative (Pseudomonas aeruginosa (PAO1), and Escherichia coli (E. coli)) bacteria was evaluated by the means of minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and inhibitory zone (IZ). 2 showed 10 to 20-fold higher activity than 1 against the bacteria tested. Moreover the 3 decreases the abundance of Gram-positive microbes up to 30% (St. aureus) and up to 20% (PAO1) the Gram-negative ones. The noteworthy antimicrobial activity of the obtained composite 3 suggests an effective antimicrobial additive for infection-free contact lenses.

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Innovative material containing the natural product curcumin, with enhanced antimicrobial properties for active packaging

Cited by 41 publications

References 16 publications

Nuclear Magnetic Resonance (NMR) Spectroscopy in Food Science: A Comprehensive Review

Nuclear Magnetic Resonance (NMR) Spectroscopy in Food Science: A Comprehensive Review

Conjugation of Penicillin-G with Silver(I) Ions Expands Its Antimicrobial Activity against Gram Negative Bacteria

An Efficient Disinfectant, Composite Material {SLS@[Zn3(CitH)2]} as Ingredient for Development of Sterilized and Non Infectious Contact Lens

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