Innovative methodology based on the thermo-denuder principle for the detection of combustion-related solid particles or high boiling point droplets: Application to 3R4F cigarette and the Tobacco Heating System THS 2.2

Air quality assessment of the Tobacco Heating System 2.2 under simulated residential conditions

“…Apart from this, a plausible explanation for the differences in measurements of suspended PM could be as follows. The mainstream aerosol of THS 2.2 contains respirable liquid-based PM (< 2.5 μm) mainly composed of water and glycerin (Pratte et al 2017(Pratte et al , 2018Schaller et al 2016), thus being an aerosol with characteristics of mist. These aerosol droplets dissipate quickly in the indoor environment after release, as evaluated by machine smoking (less than 1 min).…”

Reduced Chronic Toxicity and Carcinogenicity in A/J Mice in Response to Life-Time Exposure to Aerosol From a Heated Tobacco Product Compared With Cigarette Smoke

“…The purpose of THS 2.2 is to deliver a nicotine-containing aerosol from tobacco, with significantly reduced levels of the toxicants found in CS. When compared with CS, THS 2.2 aerosol contains significantly lower levels of toxicants, including harmful and potentially harmful constituents (HPHCs) ( Mallock et al , 2018 ; Schaller et al , 2016a , b ), and free radicals ( Shein and Jeschke, 2019 ) and no carbon-based solid particles ( Pratte et al , 2017 , 2018 ). A series of studies have demonstrated that, relative to CS, THS 2.2 aerosol has significantly reduced cytotoxicity, reduced mutagenic potency in the mouse lymphoma assay, and no mutagenic effect in the Ames assay ( Schaller et al , 2016a ; Thorne et al , 2018 ); it also has a reduced biological impact on human 3D organotypic bronchial, small airway, and oral epithelial cultures ( Gonzalez-Suarez et al , 2016 ; Iskandar et al , 2017a , b ; Zanetti et al , 2016 ) and significantly reduced systemic toxicity, lung inflammation, respiratory tract alterations, and disease risk in rodent laboratory models of chronic obstructive pulmonary disease (COPD) and atherosclerosis ( Oviedo et al , 2016 ; Phillips et al , 2016 , 2019a ; Wong et al , 2016 ).…”

The product science of electrically heated tobacco products: a narrative review of the scientific literature

“…Analysis of the aerosol produced by the THS 2.2 heated tobacco product and the mainstream smoke produced by the 3R4F Kentucky Reference cigarette indicated that whilst the conventional cigarette released significant quantities of solid carbon particles (10 12 particles present in mainstream smoke over eleven puffs), no such particles were detected with the heated tobacco product, which was suggested by the authors to indicate the absence of both combustion and pyrolysis (Pratte et al, 2017). A subsequent study published by the same authors further corroborated this finding using a methodology involving a thermo-denuder operating at 300°C (Pratte et al, 2018). Results from this study indicated that whilst mainstream smoke from the 3R4F Kentucky Reference cigarettes contained solid particles or high boiling point droplets far above the lower limit of quantification of the analytical method employed, the aerosol produced from the THS 2.2 heated tobacco product did not.…”