Innovative motor and cognitive dual-task approaches combining upper and lower limbs may improve dementia early detection

Mancioppi, Gianmaria; Fiorini, Laura; Rovini, Erika; Zeghari, Radia; Gros, Auriane; Manera, Valéria; Robert, Philippe; Cavallo, Filippo

doi:10.1038/s41598-021-86579-3

Cited by 22 publications

(22 citation statements)

References 38 publications

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“…Our results are consistent with other analyses, which show the association of dualtask tests with cognitive function [20][21][22]. Participants walked the standard TUG for the dual-task animals while subtracting serial 7s from 100 aloud or enumerating animals aloud.…”

Section: Discussionsupporting

confidence: 91%

“…A total of 155 (62%) cases TUG manual; 23 (9.2%) had cognitive and 72 (28.2%) physical problems while performing tasks. The median score was 16 (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23) seconds, stride number during the test-23 (19)(20)(21)(22)(23)(24)(25)(26)(27)(28), and while turning around-6 (5)(6)(7)(8). DTC was 11 (0-25)%.…”

Section: Single Task and Dual-task Gait Test Resultsmentioning

confidence: 99%

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The Performance of Dual-Task Tests Can Be a Combined Neuro-Psychological and Motor Marker of Mild Cognitive Impairment, Depression and Dementia in Geriatric Patients—A Cross-Sectional Study

Kasiukiewicz

Magnuszewski

Swietek

et al. 2021

JCM

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The study aims to assess the performance of dual-task tests in the geriatric population and their association with the cognitive status of the patients. Methods: Patients admitted to the Department of Geriatrics, Hospital of the Ministry of Interior and Administration on Bialystok, Poland, in 2019 and 2020 were enrolled in the study. Data on the patients’ clinical, functional, and cognitive status were collected based on the comprehensive geriatric assessment. Dual-task tests included Timed Up and Go (TUG) test while counting backward (CB7), enumerating animals (EA), and holding a cup (TUG M). Results: 250 patients were included in the study, with a median age of 81.5 years (IQR 76–86) and most above 75 years of age (80.8%). Only 29 (11.6%) of study participants had no cognitive or mood disorders. Depression was diagnosed in 30.4%, MCI in 12%, and dementia in 38.4% of cases with median Mini-Mental Score Evaluation (MMSE) 17 (12–20) points. Dual-task TUG CB7 results did not differ between cognitive conditions of patients. TUG EA differed between healthy controls and other cognitive groups and TUG between healthy controls and depression and dementia, but not mild cognitive impairment (MCI). The performance of all dual-task tests differed in patients with and without dementia. Ability to finish TUG CB7 was low even in the group without dementia. There were statistically significant differences in median scores of MMSE and Clock Drawing Test (CDT) between patients who were able or not to finish single and dual-task gait tests. Conclusion: Dual-task test results and the performance of these tasks can differentiate patients with depression, MCI and dementia compared to healthy controls in the geriatric population.

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Section: Discussionsupporting

confidence: 91%

Section: Single Task and Dual-task Gait Test Resultsmentioning

confidence: 99%

The Performance of Dual-Task Tests Can Be a Combined Neuro-Psychological and Motor Marker of Mild Cognitive Impairment, Depression and Dementia in Geriatric Patients—A Cross-Sectional Study

Kasiukiewicz

Magnuszewski

Swietek

et al. 2021

JCM

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“…For example, Rosso and colleagues proposed that dual-task walking assessment can be used as a risk assessment tool for mild cognitive impairment (MCI) [ 22 ]. Similarly, Mancioppi and colleagues stated that a dual-task assessment incorporating cognitive and motor tasks is effective for MCI diagnosis [ 23 ]. Finally, de Oliveira Silva and colleagues suggested that poor dual-task gait performance should be considered as a functional screening tool for dementia [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Single-Task or Dual-Task? Gait Assessment as a Potential Diagnostic Tool for Alzheimer’s Dementia

2021

JAD

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Background: A person’s gait performance requires the integration of sensorimotor and cognitive systems. Therefore, a person’s gait may be influenced by concurrent cognitive load such as simultaneous talking. Although it has been known that gait performance of people with Alzheimer’s dementia (AD) is compromised when they attempt a dual-task walking task, it is unclear if using a dual-task gait performance during an AD assessment yields higher diagnostic accuracy. Objective: This study was designed to investigate the predictive power for AD of dual-task gait performance in an AD assessment. Methods: Participants (14 with AD and 15 healthy controls) walked across the GAITRite© Portable Walkway mat under three different cognitive load conditions: no simultaneous cognitive load, walking while counting numbers by ones, and walking while completing category naming. Results: Multiple logistic regression revealed that the high cognitive load (i.e., category naming) with or without the low cognitive load (i.e., concurrent counting) increased the proportion of variance explained by the FAP, SL, and DST. Conclusion: Dual-task walking and talking may be a more effective diagnostic feature than single-task walking in a comprehensive AD diagnostic assessment.

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“…This could, consequently, improve the prognosis of a population with access difficulties and give them an opportunity to receive specialized care. Given that there is no sufficient evidence using GS or HS to identify cognitive impairment, many recent publications suggest combining motor and cognitive measures to improve the classification of older adults at risk of dementia (52)(53)(54)(55). So far, studies have reported the usefulness of these motor biomarkers, but there is a little evidence of which specific cognitive domains are related to the motor performance.…”

Section: Discussionmentioning

confidence: 99%

Muscular Function as an Alternative to Identify Cognitive Impairment: A Secondary Analysis From SABE Colombia

et al. 2022

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BackgroundIdentification of cognitive impairment is based traditionally on the neuropsychological tests and biomarkers that are not available widely. This study aimed to establish the association between motor function (gait speed and handgrip strength) and cognitive performance in the Mini-Mental State Examination, globally and by domains. A secondary goal was calculating a cut-off point for gait speed and handgrip strength to classify older adults as cognitively impaired.MethodsThis is a secondary analysis of SABE Colombia (Salud, Bienestar & Envejecimiento), a survey that was conducted in 2015 on health, wellbeing, and aging in Colombia. This study used linear regression models to search for an association between motor function and cognitive performance. The accuracy of motor function measurements in identifying cognitive impairment was assessed with receiver operating characteristic (ROC) curves. This study also analyzed other clinical and sociodemographical variables.ResultsGait speed was associated with orientation (r2 = 0.16), language (r2 = 0.15), recall memory (r2 = 0.14), and counting (r2 = 0.08). Similarly, handgrip strength was associated with orientation (r2 = 0.175), language (r2 = 0.164), recall memory (r2 = 0.137), and counting (r2 = 0.08). To differentiate older adults with and without cognitive impairment, a gait speed cut-off point of 0.59 m/s had an area under the curve (AUC) of 0.629 (0.613–0.646), and a weak handgrip (strength below 17.5 kg) had an AUC of 0.653 (0.645-0.661). The cut-off points for handgrip strength and gait speed were significantly higher in male participants.ConclusionsGait speed and handgrip strength are similarly associated with the cognitive performance, exhibiting the most extensive association with orientation and language domains of the Mini-Mental State Examination. Gait speed and handgrip strength can easily be measured by any clinician, and they prove to be useful screening tools to detect cognitive impairment.

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Innovative motor and cognitive dual-task approaches combining upper and lower limbs may improve dementia early detection

Cited by 22 publications

References 38 publications

The Performance of Dual-Task Tests Can Be a Combined Neuro-Psychological and Motor Marker of Mild Cognitive Impairment, Depression and Dementia in Geriatric Patients—A Cross-Sectional Study

The Performance of Dual-Task Tests Can Be a Combined Neuro-Psychological and Motor Marker of Mild Cognitive Impairment, Depression and Dementia in Geriatric Patients—A Cross-Sectional Study

Single-Task or Dual-Task? Gait Assessment as a Potential Diagnostic Tool for Alzheimer’s Dementia

Muscular Function as an Alternative to Identify Cognitive Impairment: A Secondary Analysis From SABE Colombia

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