Innovative probes with aggregation-induced emission characteristics for sensing gaseous signaling molecules

Lee, Ka-Wai; Chen, Huan; Wan, Yingpeng; Zhang, Zhen; Huang, Zhongming; Li, Shengliang; Lee, Chun‐Sing

doi:10.1016/j.biomaterials.2022.121753

Cited by 21 publications

(9 citation statements)

References 159 publications

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“…We focused on phenothiazine, 9,10-dihydroacridine, and acridone, whereby the central five-membered ring of a carbazole is replaced with a six-membered heterocycle, because this structural change affects the structure and electronic state of the resulting BF 2 complexes, which should give the complexes unique photophysical and electronic properties (Figure ). In particular, given their practical applications in luminescent sensors and bioimaging probes, switching fluorescence properties induced by aggregation − or reactions with analytes − is appreciated. In this study, we synthesized 2a , 3 , and 4 , in which the carbazole moiety of 1 was replaced with phenothiazine, 9,10-dihydro-9,9-dimethylacridine, and acridone, respectively, and clarified the effects of the structure of the central six-membered ring on the photophysical and electrochemical properties of the BF 2 complexes.…”

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confidence: 99%

Phenothiazine-, Dihydroacridine-, and Acridone-Based Boron Difluoride Complexes: Synthesis and Structure–Property Relationships

et al. 2023

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confidence: 99%

Phenothiazine-, Dihydroacridine-, and Acridone-Based Boron Difluoride Complexes: Synthesis and Structure–Property Relationships

et al. 2023

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“…Thus, their emission will be boosted upon forming aggregates which are denoted as aggregation-induced emission effect (AIE) (Figure 4e). [116][117][118][119] There is also some commonly observed charge transfer phenomenon between two monomers within aggregates (Figure 4f). [120][121][122][123] When a suitable donor molecule stacks with an acceptor molecule together, the intermolecular charge transfer effect will hybridize the donor's and acceptor's molecular orbitals to generate a pair of new lowest unoccupied molecular orbital (LUMO) and highest occupied molecular orbital (HOMO).…”

Section: Photophysical Properties Of Typical Ooms Aggregatesmentioning

confidence: 99%

Organic Optoelectronic Materials: A Rising Star of Bioimaging and Phototherapy

Lee,

Wan,

Huang

et al. 2023

Advanced Materials

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Recently, many organic optoelectronic materials (OOMs), especially those used in organic light‐emitting diodes (OLEDs), organic solar cells (OSCs), and organic field‐effect transistors (OFETs), are explored for biomedical applications including imaging and photoexcited therapies. In this review, we summarize recently developed OOMs for fluorescence imaging, photoacoustic imaging, photothermal therapy, and photodynamic therapy. Relationships between their molecular structures, nano‐aggregation structures, photophysical mechanisms, and properties for various biomedical applications are discussed. Mainly four kinds of OOMs are covered: thermally activated delayed fluorescence materials in OLEDs, conjugated small molecules and polymers in OSCs, and charge‐transfer complexes in OFETs. Based on the OOM's unique optical properties, including excitation light wavelength and exciton dynamics, they are respectively exploited for suitable biomedical applications. This review is intended to serve as a bridge between researchers in the area of organic optoelectronic devices and those in the area of biomedical applications. Moreover, it provides guidance for selecting or modifying OOMs for high‐performance biomedical uses. Current challenges and future perspectives of OOMs are also discussed with the hope of inspiring further development of OOMs for efficient biomedical applications.This article is protected by copyright. All rights reserved

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“…This configuration displays exceptional sensitivity to polarity, with the triphenylamine moiety imparting the probe with noteworthy aggregation-induced emission (AIE) characteristics. 51 Hence, DHBP possesses several advantages: (i) DHBP enables dual-channel simultaneous detection of viscosity and polarity. (ii) DHBP exhibits remarkable selectivity for viscosity and polarity both in vitro and in vivo.…”

Section: Introductionmentioning

confidence: 99%

“…In this structural arrangement, the triphenylamine component serves as an electron donor, while the positively charged tetramethylpyridine segment functions as an electron acceptor, resulting in the formation of a typical “D-π-A” architecture (Scheme ). This configuration displays exceptional sensitivity to polarity, with the triphenylamine moiety imparting the probe with noteworthy aggregation-induced emission (AIE) characteristics …”

Section: Introductionmentioning

confidence: 99%

Dual-Functional Fluorescent Probe in the Diagnosis of Liver Injury and the Evaluation of Drug Therapy with Double Signal Amplification

Bian,

Liu,

Cheng

et al. 2024

Chemical & Biomedical Imaging

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Viscosity and polarity are crucial microenvironmental parameters within cells, intimately linked to the physiological activities of organisms. We constructed and synthesized an innovative dual-functional fluorescent probe, DHBP. In the green channel, the fluorescence signal notably intensifies with decreasing environmental polarity, while in the red channel, fluorescence signal amplification occurs due to the collaborative effects of viscosity and polarity, resulting in more pronounced changes. Additionally, DHBP demonstrates high sensitivity in detecting changes in polarity and viscosity induced by drug-induced inflammation in cells and mice. Importantly, DHBP has been effectively utilized to monitor alterations in viscosity and polarity in the liver injury induced by diabetes in vivo in mice and further employed to assess the therapeutic efficacy of drugs. Therefore, DHBP holds promise for advancing research on viscosity and polarity in future studies of physiological and pathological processes.

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Innovative probes with aggregation-induced emission characteristics for sensing gaseous signaling molecules

Cited by 21 publications

References 159 publications

Phenothiazine-, Dihydroacridine-, and Acridone-Based Boron Difluoride Complexes: Synthesis and Structure–Property Relationships

Phenothiazine-, Dihydroacridine-, and Acridone-Based Boron Difluoride Complexes: Synthesis and Structure–Property Relationships

Organic Optoelectronic Materials: A Rising Star of Bioimaging and Phototherapy

Dual-Functional Fluorescent Probe in the Diagnosis of Liver Injury and the Evaluation of Drug Therapy with Double Signal Amplification

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