Innovative results in the treatment of inespecific anusitis-proctitis with the use of bergamot gel (Benebeo gel)®

Danilo, Cafaro; Felipe, Celedon; Sturiale, Alessandro; Stefania, Sinicropi Maria

doi:10.29328/journal.icci.1001011

Cited by 3 publications

(5 citation statements)

References 34 publications

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“…However, the frequency of complications has decreased since 2015 [36]. Postoperative pain after stapled hemorrhoidopexy is associated with various factors such as incorrect technique, anal wounds, inflammation in the stapled ring, age, or pelvic floor nerve stimulation [38,44,54,[56][57][58]. Pain after the MM application is linked to bleeding and inflammation, often leading to acute reoperations to stop postoperative bleeding [6].…”

Section: Discussionmentioning

confidence: 99%

“…The presence of inflammation in the anorectal passage before the operation can be considered reliable when using preparations containing flavonoids, which are anti-inflammatory, antibacterial, vasoconstrictive, bleeding-reducing, and wound-healing [24,50,63]. Notably, some flavonoids were shown to inhibit gene expression and some pro-inflammatory cytokines [57].…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Clinical Manifestations of Hemorrhoidal Disease, Carried Out Surgeries and Prolapsed Anorectal Tissues: Associations with ABO Blood Groups of Patients

Fišere,

Groma,

Svirskis

et al. 2023

JCM

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Hemorrhoidal disease (HD) is a chronic multifactorial disease. Increased abdominal pressure, along with hyperperfusion, neovascularization, overexpression of inflammatory mediators, and dysbiosis, contributes to the development of HD. The deterioration of the anchoring connective tissue with reduced collagen content and altered collagen ratios, dilatation of blood vessels and thrombosis, muscle injury, and inflammation gradually lead to clinically manifesting prolapse and bleeding from hemorrhoids. The associations of the ABO blood types with a disease have been investigated for the upper gastrointestinal tract only. This study aimed to evaluate HD clinical manifestations, surgeries carried out, and the status of prolapsed anorectal tissues by exploring the associations with the patients’ ABO blood groups. Clinical and various morphological methods, combined with extensive bioinformatics, were used. The blood type 0, grade III and IV HD individuals constituted the largest group in a moderately-sized cohort of equally represented males and females studied and submitted to surgical treatment of hemorrhoids. There were significantly more complaints reported by HD females compared to males (p = 0.0094). The Longo technique appeared mostly used, and there were proportionally more surgeries performed below the dentate line for HD individuals with blood type 0 compared to other blood type patients (24% vs. 11%). HD males were found to present with significantly more often inflamed rectal mucosa (p < 0.05). Loosening and weakening of collagenous components of the rectal wall combined with vascular dilation and hemorrhage was found to differ in 0 blood type HD individuals compared to other types. HD males were demonstrated to develop the ruptures of vascular beds significantly more often when compared to HD females (p = 0.0165). Furthermore, 0 blood type HD males were significantly more often affected by a disease manifested with tissue hemorrhage compared to the 0 blood type HD females (p = 0.0081). Collectively, the local status of chronically injured anorectal tissue should be considered when applying surgical techniques. Future studies could include patients with HD grades I and II to gain a comprehensive understanding of the disease progression, allowing for a comparison of tissue changes at different disease stages.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of Clinical Manifestations of Hemorrhoidal Disease, Carried Out Surgeries and Prolapsed Anorectal Tissues: Associations with ABO Blood Groups of Patients

Fišere,

Groma,

Svirskis

et al. 2023

JCM

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“…Clinically, innovative results came from the treatment of patients affected by anitis/proctitis after treatment with a bergamot oil (known as Benebeo ® gel, Wellvit, Cosenza, Italia). The local administration of bergamot gel, containing hesperidin, naringenin, apigenin and eriocitrin as major components, produced anti-inflammatory effects (improvement in local bleeding and hyperemia), promoting a fast-healing process in situ [ 97 ]. The evidence of bergamot derivatives and byproducts against the abovementioned disorders is reported in Table 7 .…”

Section: Anti-inflammatory Activity Of Bergamot Derivatives and Bypro...mentioning

confidence: 99%

Bergamot Byproducts: A Sustainable Source to Counteract Inflammation

Russo,

Lombardo,

Bruschetta

et al. 2024

Nutrients

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Chronic inflammation is the result of an acute inflammatory response that fails to eliminate the pathogenic agent or heal the tissue injury. The consequence of this failure lays the foundations to the onset of several chronic ailments, including skin disorders, respiratory and neurodegenerative diseases, metabolic syndrome, and, eventually, cancer. In this context, the long-term use of synthetic anti-inflammatory drugs to treat chronic illnesses cannot be tolerated by patients owing to the severe side effects. Based on this, the need for novel agents endowed with anti-inflammatory effects prompted to search potential candidates also within the plant kingdom, being recognized as a source of molecules currently employed in several therapeutical areas. Indeed, the ever-growing evidence on the anti-inflammatory properties of dietary polyphenols traced the route towards the study of flavonoid-rich sources, such as Citrus bergamia (bergamot) and its derivatives. Interestingly, the recent paradigm of the circular economy has promoted the valorization of Citrus fruit waste and, in regard to bergamot, it brought to light new evidence corroborating the anti-inflammatory potential of bergamot byproducts, thus increasing the scientific knowledge in this field. Therefore, this review aims to gather the latest literature supporting the beneficial role of both bergamot derivatives and waste products in different models of inflammatory-based diseases, thus highlighting the great potentiality of a waste re-evaluation perspective.

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“…A recent study suggested that the antiinflammatory function of Benebeo Gel® may be due to reduction of the intracellular free radicals, in particular of the COX-2, and to the inhibition of prostaglandins and leukotrienes production [49]. It has demonstrated to stimulate tissues repairing and vasoprotective effect thus is also being suggested in the treatment of anusitis-proctitis [50]. The aim of this study was to evaluate the effect of Benebeo Gel ® in patients for post-operative wound healing after open haemorrhoidectomy.…”

Section: Benebeo Gelmentioning

confidence: 99%

“…It has also shown nephroprotective against cisplatin-induced renal toxicity by alleviating oxidative stress, preventing apoptosis and DNA damage [74] and has been suggested as a novel chemotherapeutic agent to treat breast cancer [75]. It acts also as an epithelizing, antiinfective, emollient, anti-edematous, local anesthetic agent and lipid-lowering agent [50,76,77]. Interestingly, eriocitrin has shown the ability to stimulate the processes of tissue regeneration in the treatment of cutaneous wounds along with a decrease in capillary permeability [78].…”

Section: Bergamot Essential Oil (Beo) and Its Flavonoidsmentioning

confidence: 99%

Clinical Trial: Management of Post-Haemorrhoidectomy Wound Healing by Bergamot Flavonoid-Based Gel and Sodium Hyaluronate: An Observational, Multicentric Trial

Cafaro,

Onofrio,

Sturiale

et al. 2023

J. Pharm. Nutr. Sci.

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Objective: Haemorrhoidal disease (HD) is a very diffuse anorectal condition that involves a large part of the population, both male and female of every age. Among the procedures proposed to treat HD, conventional excisional surgery remains one of the most performed. Milligan-Morgan (MM) technique is one of the most used haemorrhoidectomy techniques. In this technique, the wounds are left open and re-epithelialization requires almost 3-5 weeks, in which patients generally experience pain and intense discomfort improving over the weeks. Methods: The aim of this study was to evaluate the effect of topic administration of Benebeo Gel®, mainly composed by bergamot-derived flavonoids and hyaluronic acid, on post-operative wound healing after open MM haemorrhoidectomy. An observational prospective study was carried out, involving 205 patients aged between 18 and 75. Results and Conclusion: The results after 2 weeks of treatment seem to be promising with a very good clinical outcome and patient satisfaction within 1 month.

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Innovative results in the treatment of inespecific anusitis-proctitis with the use of bergamot gel (Benebeo gel)®

Cited by 3 publications

References 34 publications

Evaluation of Clinical Manifestations of Hemorrhoidal Disease, Carried Out Surgeries and Prolapsed Anorectal Tissues: Associations with ABO Blood Groups of Patients

Evaluation of Clinical Manifestations of Hemorrhoidal Disease, Carried Out Surgeries and Prolapsed Anorectal Tissues: Associations with ABO Blood Groups of Patients

Bergamot Byproducts: A Sustainable Source to Counteract Inflammation

Clinical Trial: Management of Post-Haemorrhoidectomy Wound Healing by Bergamot Flavonoid-Based Gel and Sodium Hyaluronate: An Observational, Multicentric Trial

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