The purpose of the present research was to investigate the agents involved in an innovation ecosystem within the realm of the creative industry, drawing on relevant international literature. The interest emerged from the need to assess the existence of international examples identifying new innovative protagonists. To this end, a systematic review of publications indexed in the Web of Science database was undertaken, using the content analysis method based on Bardin (2016). After developing the protocol for filtering and analysis, 46 articles published on the platform between 2020 and 2024 were identified and examined. It is possible to observe that the discussion about innovation ecosystems and the creative industry transcends regional boundaries, addressing the need to integrate both urban and rural areas. This integration is achieved through the creation of innovation districts, innovation zones, creativity collectives, creative cities, and smart cities, all spaces guided by sustainability concerns, with the purpose of unifying the interests of industry, civil society, government, and academia. For the effective generation of innovative products, it becomes indispensable to have creative professionals endowed with specific managerial skills, supported by well-defined business models and organizational flows. Furthermore, it is essential to maintain constant attention to aspects related to intellectual property rights and the implementation of public policies that promote the development of the creative industry.