Innovative snail-mucus-extract (SME)-coated nanoparticles exhibit anti-inflammatory and anti-proliferative effects for potential skin cancer prevention and treatment

Valeria, Consoli; Salvatore, Petralia; Luca, Vanella; Maria, Gulisano; Ludovica, Maugeri; Cristina, Satriano; Lucia, Montenegro; Angela, Castellano; Valeria, Sorrenti

doi:10.1039/d4ra00291a

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“…Many reports of antibacterial, antifungal, larvicidal, anti-termite [ 61 , 62 , 63 , 64 , 65 ], and anticancer [ 66 , 67 ] activities of CuONPs derived from plants, animals, and microorganisms. Furthermore, several studies conducted in recent years have demonstrated the advantages of employing snail mucus to synthesize Ag and AuNPs, which have been shown to have broad-spectrum antibacterial activity, anticancer potential, and anti-inflammatory properties [ 21 , 68 ]. Based on the presented investigations, it can be assumed that CuONPs obtained from the C. aspersum mucus with MW > 20 kDa also show in vitro antibacterial activity.…”

Section: Discussionmentioning

confidence: 99%

Development of CuO Nanoparticles from the Mucus of Garden Snail Cornu aspersum as New Antimicrobial Agents

Dolashka,

Marinova,

Petrov

et al. 2024

Pharmaceuticals

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Several biologically active compounds involved in the green synthesis of silver and gold nanoparticles have been isolated from snail mucus and characterized. This paper presents a successful method for the application of snail mucus from Cornu aspersum as a bioreducing agent of copper sulfate and as a biostabilizer of the copper oxide nanoparticles (CuONPs-Muc) obtained. The synthesis at room temperature and neutral pH yielded nanoparticles with a spherical shape and an average diameter of 150 nm. The structure and properties of CuONPs-Muc were characterized using various methods and techniques, such as ultraviolet–visible spectroscopy (UV–vis), high-performance liquid chromatography (HPLC), one-dimensional polyacrylamide gel electrophoresis (1D-PAGE), up-conversion infrared spectroscopy Fourier transform (FTIR), scanning electron microscopy combined with energy dispersive spectroscopy (SEM/EDS), Raman spectroscopy and imaging, thermogravimetric analysis (TG-DSC), etc. Mucus proteins with molecular weights of 30.691 kDa and 26.549 kDa were identified, which are involved in the biogenic production of CuONPs-Muc. The macromolecular shell of proteins formed around the copper ions contributes to a higher efficiency of the synthesized CuONPs-Muc in inhibiting the bacterial growth of several Gram-positive (Bacillus subtilis NBIMCC2353, Bacillus spizizenii ATCC 6633, Staphylococcus aureus ATCC 6538, Listeria innocua NBIMCC8755) and Gram-negative (Escherichia coli ATCC8739, Salmonella enteitidis NBIMCC8691, Salmonella typhimurium ATCC 14028, Stenotrophomonas maltophilia ATCC 17666) bacteria compared to baseline mucus. The bioorganic synthesis of snail mucus presented here provides CuONPs-Muc with a highly pronounced antimicrobial effect. These results will expand knowledge in the field of natural nanomaterials and their role in emerging dosage forms.

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Section: Discussionmentioning

confidence: 99%

Development of CuO Nanoparticles from the Mucus of Garden Snail Cornu aspersum as New Antimicrobial Agents

Dolashka,

Marinova,

Petrov

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

Innovative snail-mucus-extract (SME)-coated nanoparticles exhibit anti-inflammatory and anti-proliferative effects for potential skin cancer prevention and treatment

Abstract: Nowadays, several studies have highlighted the ability of snail mucus in maintaining healthy skin conditions due to its emollient, regenerative and protective properties.

Cited by 1 publication

References 50 publications

Development of CuO Nanoparticles from the Mucus of Garden Snail Cornu aspersum as New Antimicrobial Agents

Development of CuO Nanoparticles from the Mucus of Garden Snail Cornu aspersum as New Antimicrobial Agents

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