Innovative SPE-LC-MS/MS technique for the assessment of 63 pharmaceuticals and the detection of antibiotic-resistant-bacteria: A case study natural water sources in Lebanon

Mokh, Samia; Khatib, Mohammad El; Koubar, Mohamad; Daher, Zeina; Iskandarani, Mohamad Al

doi:10.1016/j.scitotenv.2017.07.230

Cited by 76 publications

(54 citation statements)

References 41 publications

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“…The findings in this present study were in agreement with our previous studies [11,19]. The precision of the method was evaluated based on the results of the analysis of three concentrations (8,40, and 200 ng/mL) with three replications for each one on the same day and the results from inter-day precision from the other three different days. The values were compared with the standards; thus, all values demonstrated good results with RSD% ≤ 6.7% for intra-day precision and 11.7% for inter-day precision (see Table 4).…”

Section: Methods Validationsupporting

confidence: 91%

“…[7]. So far, solid phase extraction is considered one of the most frequently employed extraction techniques in the analysis of pharmaceuticals in water, as it offers high selectivity, precision, and extraction efficiency [8][9][10]. The most common solid phase extraction (SPE) materials that allow the retention of a wide variety of compounds are the copolymer poly (divinylbenzene-co-N-vinylpyrrolidone) (Oasis HLB) that has both hydrophilic and lipophilic retention characteristics, and it can be used to retain both polar and non-polar compounds [10,11].…”

Section: Introductionmentioning

confidence: 99%

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Transportation of Different Therapeutic Classes of Pharmaceuticals to the Surface Water, Sewage Treatment Plant, and Hospital Samples, Malaysia

Al-Qaim

Mussa

Yuzir

et al. 2018

Water

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All pharmaceuticals are separated chromatographically using the liquid chromatographytime of flight/mass spectrometry (LC-ToF/MS) on a 5 µm, 2.1 mm × 250 mm, C18 column at 0.3 mL/min. The recovery is investigated at two spiking levels, 10 and 1 ng/mL; the mean recovery is higher than 77, 84, and 93% in sewage treatment plants (STP) influent, STP effluent, and surface water, respectively. The limit of quantification (LOQ) averages 29, 16, 7, and 2 ng/L in STP influent, STP effluent, surface water, and drinking water, respectively. The matrix effect is also evaluated in STP influent and effluent. It is observed that sulfamethoxazole, prednisolone, ketoprofen, and glibenclamide are highly impacted compared to other compounds, −99, −110, 77, and 91%, respectively. The results show that six out of nine pharmaceuticals, namely atenolol, acetaminophen, theophylline, caffeine, metoprolol, and sulfamethoxazole are detected in STP influent, STP effluent, and surface water. However, the means of concentration are 561, 3305, 1805, 3900, 78, and 308 ng/L for atenolol, acetaminophen, theophylline, caffeine, metoprolol, and sulfamethoxazole, respectively, in STP influent. Caffeine and acetaminophen are detected with the highest concentration, reaching up to 8700 and 4919 ng/L, respectively, in STP influent.

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Section: Methods Validationsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Transportation of Different Therapeutic Classes of Pharmaceuticals to the Surface Water, Sewage Treatment Plant, and Hospital Samples, Malaysia

Al-Qaim

Mussa

Yuzir

et al. 2018

Water

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“…In general, it could be concluded that non-routine episodes associated with untreated effluents, landfills and medical wastewaters from urban inhabitants would exacerbate the pollution of antibiotics [33,34]. Furthermore, compared with previous studies, the mean CIP concentration for the water samples (169.2 ± 107.9 ng/L) was of similar levels to some other aquatic environments, such as the Wangyang River in China (205.5 ng/L) [35], Lebanese rivers (108 ng/L) [36], and the rivers in Northern Pakistan (110 ng/L) [37]. However, it was far greater than that in the water samples of Seine River (France) [38], Yangtze Estuary (China) [39], and Pearl River (China) [40], as well as other catchments in China (Poyang Lake, Chao Lake, and Liao River) [27,41,42].…”

Section: Antibiotics In the Water Phase Of The Hrdrmentioning

confidence: 68%

Occurrence, Distribution, and Risk Assessment of Antibiotics in a Subtropical River-Reservoir System

Chen

Zhang

et al. 2018

Water

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Antibiotic pollutions in the aquatic environment have attracted widespread attention due to their ubiquitous distribution and antibacterial properties. The occurrence, distribution, and ecological risk assessment of 17 common antibiotics in this study were preformed in a vital drinking water source represented as a river-reservoir system in South China. In general, 15 antibiotics were detected at least once in the watershed, with the total concentrations of antibiotics in the water samples ranging from 193.6 to 863.3 ng/L and 115.1 to 278.2 µg/kg in the sediment samples. For the water samples, higher rain runoff may contribute to the levels of total concentration in the river system, while perennial anthropic activity associated with the usage pattern of antibiotics may be an important factor determining similar sources and release mechanisms of antibiotics in the riparian environment. Meanwhile, the reservoir system could act as a stable reactor to influence the level and composition of antibiotics exported from the river system. For the sediment samples, hydrological factor in the reservoir may influence the antibiotic distributions along with seasonal variation. Ecological risk assessment revealed that tetracycline and ciprofloxacin could pose high risks in the aquatic environment. Taken together, further investigations should be performed to elaborate the environmental behaviors of antibiotics in the river-reservoir system, especially in drinking water sources.

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“…The results of analyzing real spiked water samples revealed recoveries between 82% and 88% for concentrations between 20 and 200 µg/L. A multi-residue method for the determination of ten emerging contaminants in soil was presented by Mokh et al (2017). The optimized method used acetonitrile:water (60:40) to elute the analytes from HLB SPE cartridges which were used to extract acidified samples followed by electrospray ionization mass spectrometry.…”

Section: Methodsmentioning

confidence: 99%

Detection, Occurrence and Fate of Emerging Contaminants in Agricultural Environments

Snow

Cassada

Biswas

et al. 2018

Water Environment Research

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A total of 75 papers published in 2017 were reviewed ranging from detailed descriptions of analytical methods, to fate and occurrence studies, to ecological effects and sampling techniques for a wide variety of emerging contaminants likely to occur in agricultural environments. New methods and studies on veterinary pharmaceuticals, steroids, antibiotic resistance genes, and engineered nanoparticles agricultural environments continue to expand our knowledge base on the occurrence and potential impacts of these compounds. This review is divided into the following sections: Introduction, Analytical Methods, Fate and Occurrence, Pharmaceutical Metabolites, Anthelmintics, Antibiotic Resistence Genes, and Engineered Nanomaterials.

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Innovative SPE-LC-MS/MS technique for the assessment of 63 pharmaceuticals and the detection of antibiotic-resistant-bacteria: A case study natural water sources in Lebanon

Cited by 76 publications

References 41 publications

Transportation of Different Therapeutic Classes of Pharmaceuticals to the Surface Water, Sewage Treatment Plant, and Hospital Samples, Malaysia

Transportation of Different Therapeutic Classes of Pharmaceuticals to the Surface Water, Sewage Treatment Plant, and Hospital Samples, Malaysia

Occurrence, Distribution, and Risk Assessment of Antibiotics in a Subtropical River-Reservoir System

Detection, Occurrence and Fate of Emerging Contaminants in Agricultural Environments

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