Innovative strategy with potential to increase hemodialysis efficiency and safety

Abstract

Uremic toxins are mainly represented by blood urine nitrogen (BUN) and creatinine (Crea) whose removal is critically important in hemodialysis (HD) for kidney disease. Patients undergoing HD have a complex illness, resulting from: inadequate removal of organic waste, dialysis-induced oxidative stress and membrane-induced inflammation. Here we report innovative breakthroughs for efficient and safe HD by using a plasmon-induced dialysate comprising Au nanoparticles (NPs)-treated (AuNT) water that is distinguishable from conventional deionized (DI) water. The diffusion coefficient of K3Fe(CN)6 in saline solution can be significantly increased from 2.76, to 4.62 × 10−6 cm s−1, by using AuNT water prepared under illumination by green light-emitting diodes (LED). In vitro HD experiments suggest that the treatment times for the removals of 70% BUN and Crea are reduced by 47 and 59%, respectively, using AuNT water instead of DI water in dialysate, while additionally suppressing NO release from lipopolysaccharide (LPS)-induced inflammatory cells.

Effective Energy Transfer via Plasmon-Activated High-Energy Water Promotes Its Fundamental Activities of Solubility, Ionic Conductivity and Extraction at Room Temperature

“…Increasing the ionic conductivity in high-energy and electron-doping AuNT water with weak HBs was never expected before. In our previous study 21 , it was reported that AuNT water’s weak HBs were responsible for the correspondingly novel performance in solute diffusion, which is a critical factor for hemodialysis efficiency. The calculated diffusion coefficient of 30 mM K 3 Fe(CN) 6 (involving a one-electron reaction) increased from 2.76 × 10 −6 to 4.62 × 10 −6 cm s −1 (an increase of ~67%) when using an AuNT water-based saline solution instead of a conventional DI water-based saline solution.…”

“…The super SWC water was obtained by irradiating DI water-wetted Au NPs supported on ceramic particles with laser light at 532 nm in situ Raman spectrum measurement. The created bulk liquid water is energetic and in an electron-doping state, shows promise in its innovative availability to increase the efficiency and safety of hemodialysis 21 . In this work, we present innovative applications of room-temperature high-energy bulk liquid water by promoting water’s fundamental activities of solubility, ionic conductivity, and extraction, which are never considered when using conventional DI water.…”

One-step fabrication of SERS-active substrates based on plasmon-induced activated water, with improved activity and excellent reproducibility

“…In our previous report [21], innovative AuNT water [18] with weak HBs was successfully utilized for efficient and safe hemodialysis (HD). In this previous report, compared to DI water, a distinct property was noted for AuNT water of a higher diffusion coefficient (by ca.…”

Design of Mobile Hemodialysis Apparatus for Acute Renal Failure Patient's Self-Help and Treatment Adherence

“…Hsiao-Chien Chen and Hsiu-Chen Lin have discussed about the breakthroughs of Plasmon-induced dialysate efficient and safe HD by using comprising it with Au Nano particles (NPs)-treated with (AuNT) water from conventional de-ionised (DI) water that is distinguishable [59].They also discussed about HD efficacies which are unprecedented and found using AuNT water along high diffusion coefficients activities with weak hydrogen bonds are reported for the first time.…”