Innovative Surgical Treatment of Severe Cherubism

Son, Ji; Marshall, Danielle C.; Valiathan, Manish; Otteson, Todd D.; Ferretti, Gerald A.; Grigorian, Paula A.; Rosen, Carol L.; Becker, Devra B.; Rowe, David J.; Soltanian, Hooman; Lakin, Gregory E.

doi:10.1177/1055665618774008

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…There are many aspects to consider when pursuing surgical intervention in cases of cherubism. 9 Early surgical intervention may potentially prevent long-term sequalae. The removal of tumor may limit the overall disease process, which in turn may prevent permanent tooth loss and normalize facial aesthetics through their formative and consequent years.…”

Section: Discussionmentioning

confidence: 99%

Severe Cherubism Treated with Curettage, Osteotomy, and Bony Repositioning: A Case Series of Three Patients

Moss

Pires

Zahid

et al. 2022

Plastic and Reconstructive Surgery - Global Open

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Summary: Cherubism is a rare, autosomal dominant condition characterized by the replacement of medullary bone by fibro-osseous lesions, predominantly in the bilateral maxillae and/or mandibles. The clinical presentation of cherubism can vary widely, from clinically undetectable to severe facial disfigurement. Although there are no established management guidelines for this condition, conservative management with observation is typically favored in most cases due to the possibility of spontaneous regression following puberty. In this article, we present three cases of moderate to severe cherubism managed with early surgical intervention utilizing curettage and osteotomy followed by bony repositioning. We aimed to show the feasibility and safety of this minimally invasive surgical technique in the management of moderate to severe cases of cherubism to provide improvement in patient quality of life, aesthetics, and function while also possibly mitigating the need for later reconstructive surgery.

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Section: Discussionmentioning

confidence: 99%

Severe Cherubism Treated with Curettage, Osteotomy, and Bony Repositioning: A Case Series of Three Patients

Moss

Pires

Zahid

et al. 2022

Plastic and Reconstructive Surgery - Global Open

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“…This may cause abnormality of eruption timing, partial anodontia, and incomplete retention of erupted permanent teeth [16,17]. Some authors believe that the treatment of cherubism should include opening cystic cavities and cleaning them thoroughly [18,19]. Other researchers believe that because most cases of cherubism regress spontaneously with age, operative treatment may not be necessary [20].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic assessment and treatment of cherubism as prevention of ocular complications

Nazaryan¹,

Mikhailenko²,

Yaroslavska³

et al. 2022

Oftalmol Zh

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This is an initiative study. Cherubism as a form of fibrous dysplasia of jaw bones is a congenital hereditary abnormality of osseous tissue maturation. Although the disease requires mostly maxillofacial surgery and orthodontic care, patients also have to be consulted by an ophthalmologist. The purpose of this study was to share our experience in the diagnostic assessment and treatment of cherubism, a rare form of fibrous dysplasia that is commonly misdiagnosed, which results in inadequate treatment and may lead to serious ocular complications. We present our experience of diagnostic assessment and treatment of four patients with cherubism for one to twenty years. The diagnosis of cherubism became evident after histological study of the material excised during surgery, because postoperative histology showed that changes were not cancerous (adamantinoma), but dysplastic. In addition, new foci developed or old foci recurred some time after surgery. Consequently, true jaw tumors must be correctly differentiated from dental cysts and from dysplastic bone lesions. Patients were followed up once every 6 months. Over the period of follow-up, ocular involvement was observed in the woman who had been diagnosed in childhood with congenital mixed astigmatism. Given our observations, one may make a conclusion that cherubism, a rare form of fibrous dysplasia, is a hereditary or familial disorder, and regresses after completion of puberty and puberty-related changes in hormonal milieu. Timely orthodontic care (and, if required, maxillofacial surgery care) will facilitate preventing the progression of the disease and its ophthalmological consequences. Special attention of ophthalmologists should be paid to cherubism patients with maxillary lesions.

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Clinicoradiologic follow up of cherubism with aggressive characteristics: a series of 3 cases

Gupta

Singh

Garg

et al. 2019

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Innovative Surgical Treatment of Severe Cherubism

Cited by 3 publications

References 21 publications

Severe Cherubism Treated with Curettage, Osteotomy, and Bony Repositioning: A Case Series of Three Patients

Severe Cherubism Treated with Curettage, Osteotomy, and Bony Repositioning: A Case Series of Three Patients

Diagnostic assessment and treatment of cherubism as prevention of ocular complications

Clinicoradiologic follow up of cherubism with aggressive characteristics: a series of 3 cases

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